1.Effects of Compound LJZ on Antitumor Activity and Immune Function in Tumor Bearing Mice
Yanli ZHANG ; Chaixia LI ; Yuxi JIN ; Chen QING
Journal of Kunming Medical University 2006;0(06):-
Objective To investigate effects of compound LJZ on antitumor activity and immune function in mice bearing implanted tumor in vivo.Methods The antitumor effects on the sarcoma 180(S180) and hepatoma 22(H22) bearing in mice were evaluated by weight of tumor.The effects of compound LJZ on specific immunity function were observed by delayed-type hypersensitivity(DTH) response induced by 2,4-dinitro-1-fluorobenzene(DNFB)and the effects of compound LJZ on non-specific immunity function were studied by macrophage phagocytosing neutral red.Results Compound LJZ inhibited significantly the growth of S180 and H22 bearing in mice,and showed dose-dependent relationship.Compound LJZ could enhance the phagocytic capacity of macrophage in bearing S180 mice.But it had no effect on DTH.Conclusion Compound LJZ has significant antitumor effects in vivo,and the effects on phagocytic capacity of macrophage maybe one of its antitumor mechanisms.
2.Study on the EEG characteristics and its correlation with visual attention function in attention deficithyperactivity disorder
Xia LI ; Tongkun SHI ; Jia SONG ; Chaixia SUN ; Wei XIA ; Lijie WU
Chinese Journal of Behavioral Medicine and Brain Science 2011;20(7):592-594
Objective To explore the EEG characteristics and the correlation between EEG characteristics and visual attention function in attention deficit/hyperactivity disorder(ADHD).Methods 1:1 case-control study wag applied(37 ADHD children were compared with 37 healthy control groups).Participants aged from 6 to 14 years were involved in this study.All children were tested EEG characteristics and visual function,including the frequency,amplitude,relative power and counting missing features test.And the correlation was analyzed between relative power and visual function.Results The θ amplitude((20.48±14.99μV)in ADHD wag significantly higher than that in the control group((12.37±8.06)μV),(P<0.05);the β frequency((16.63±1.72)Hz) in ADHD was significantly lower than that in the control group((16.63±1.72)Hz,P<0.05);the relative power of β in ADHD(5.24±1.24)was significantly lower than that in the control group(6.30±1.19),(P<0.05);the θ/β ratio in ADHD(4.22±1.26)was significantly higher than that in the control group(3.41±0.52)(P<0.05);the double eyes'counting missing features mark(56.76±19.16),(49.73±23.39) in ADHD were significantly lower than that in the control group(72.43 ±17.23),(71.35±16.69).There wag significant negative correlation between the θ relative power and double eyes'counting missing features(r=-0.448 and-0.361);the θ/β ratio had significantly negative correlation with the fight eye's counting missing features(r=-0.352).Conclusion Compare to the normal control group,the ADHD group shows significant difference in EEG characteristics and visual attention function.The change of EEG power characteristics hag a significant affect on the allocation of attention.