Objective To assess the damage of secondary focal segmental glomerulosclerosis(sFSGS) in IgA nephropathy (IgAN). Methods Clinical and pathological data on 182 patients with IgAN were analysed quantitatively ,who had pathological damage of sFSGS.The clinical data included gender,age,blood pressure,urine protein,serum creatinine (Scr),blood urea nitrogen (Bun),uric acid (UA),blood cholesterol (Ch),triglycerides (TG),serum total protein (TP),albumin (Alb) and creatinine clearance rate (Ccr).The data of pathology included quantitive integration in focal and segmental glomerulosclerosis,cellular proliferation,mesangial proliferation,crescent,inflammatory cell infiltration,interstitial fibrosis,tubule atrophy and angio-lesion.The multivariate over univariate statistical analyses had been done,finding the correlation among the factors.Results The most common clinical type of 182 patients' was asymtomatic urine abnormality(50.55%),then were hypertension with/no chronic renal function failure and mass proteinura/nephrotic syndrome.The quantitive value of urine protein,Scr,Bun and UA increased as exacerbation of sFSGS' degree.It showed that inflammatory cell infiltration,interstitial fibrosis,tubule atrophy and angio-lesion had intimate correlation with sFSGS(r_1=0.377,r_2=0.169,r_3=0.412,r_4=0.331,P