Background: Cervical cancer is one of the leading cancers in women worldwide.\r\n', u'Objectives: To evaluate the knowledge, attitude and practice towards cervical cancer and its preventive measures among the parents of young adolescent girls. \r\n', u'Subjects and methods: The cross-sectional survey was conducted in Tuliem District, Hanoi and Cu Chi District, Ho Chi Minh city. By employing a structured interview there have been 218 fathers/mothers of young adolescent girls at secondary school age (11to14 years old) participated in the survey. \r\n', u"Results: There was a limitation in the respondents' understanding about cervical cancer. Although 83% parents have been aware of cervical cancer and 89% considered it as a fatal disease, nearly a half of them does not know any symptoms of the disease. Similarly, inadequate knowledge on causes and risk factors of the disease has been common among respondents. Only 25% of parents are aware of HPV and few knew about the transmission route of this virus. HPV vaccines are still very new for parents. Only 29.8% of interviewees have heard about HPV vaccines. However, 74.3% parents have expressed a wish to have their daughters vaccinated, once HPV vaccines are introduced in Vietnam. \r\n", u'Conclusions: Knowledge, attitude and practice towards cervical cancer among parents of young adolescent girls in these district were quite limited\r\n', u'\r\n', u'
cervical cancer ; knowledge ; attitude ; practice

Objective: The object of this study was to assess the outcomes of surgical treatment of stage pT1a and pT1b1 cervical cancer.Method: The medical records of 59 patients at our institution with pT1a and pT1b1 cervical cancer who underwent an operation as their primary treatment between January 1996 and September 2006 were analyzed retrospectively.Results: Ten patients underwent an operation which was less aggressive than the current operative modality at our institution. Three patients had recurrence. No patients had recurrence resulting from insufficient operations. No patients had any histologic subtype of adnexal metastasis in the resected specimens. Two of the five patients with squamous cell carcinoma and lymph node metastases at the initial operation had recurrence. Only one patient had a histologic subtype of adenosquamous carcinoma. The patient with adenosquamous carcinoma had recurrence.Conclusion: The results suggest that the surgical procedure did not affect prognosis in the cases we analyzed by surgical modalities. The current evidence suggests that a patient in an early stage can undergo less aggressive surgery than the current operative modality requires.
Surgical aspects ; Recurrence ; Cervical Cancer ; Patients ; Stage of Surgical Procedure

A metastatic focus of small circumscribed carcinoma in an endometrial polyp is extremely rare. Most of these reported cases have a primary carcinoma of the breast. We report a circumscribed metastatic squamous cell carcinoma in an endometrial polyp. This, to the best of our knowledge, is the first case report of metastasis of cervical carcinoma to a benign endometrial polyp.
Polyps ; Neoplasm Metastasis ; Cervical Cancer ; Case Report ; Metastatic to

Cervical cancer is the third most prevalent cancer in women around the world. Recently in Korea, the incidence of cervical cancer has decreased, but in all stages of cervical intraepithelial neoplasia (CIN), CIN has shown a 91% increase from 1999 to 2008. Persistent human papillomavirus (HPV) infection has been found to be the main cause of cervical cancer. HPV types 16 and 18 have been found in 70% of cervical cancer patients around the world. Cervical cancer screening such as cytology has limitations in terms of sensitivity and specificity. A discussion about the need for the HPV test is becoming active in order to compensate for the limitation of cytology. After the role of HPV in cervical cancer was identified, the importance of HPV detection test as a screening was emphasized. Several tests have been developed and each test has its own advantages and disadvantages, and new test method to overcome the disadvantages is still being developed. Today's guidelines and tests are those you would choose from among the large number of cervical cancer screening guidelines and tests, based on the consideration that the selected guidelines and the test are effective.
Cervical Intraepithelial Neoplasia ; Early Detection of Cancer ; Female ; Humans* ; Incidence ; Korea ; Mass Screening* ; Methods ; Papillomaviridae ; Perimenopause* ; Sensitivity and Specificity ; Uterine Cervical Neoplasms*

OBJECTIVE: Ideal cancer screening program should be not only accurate but also cost-effective. However, in Korea, the two aspect of cervix cancer screening program was not yet evaluated. Thus we conducted this study to evaluate the cost-effectiveness and accuracy of various screening methods for detecting uterine cervical neoplasia. METHODS: We used various methods (conventional Pap smear, cervicography and HPV test) to detect cervical neoplasia on 255 women who visited the Seoul National University Hospital from Dec. 1996 to Jul. 1997 and analyzed the accuracy and cost-effectiveness of each method along with various combinations of methods using Bayesian theorem. The accuracy was judged by the final histopathologic diagnosis. RESULTS: Sensitivity (SE) and specificity (SP) of each method to detect cervical intraepithelial neoplasia (CIN) 1 or above were 83.0% and 69.4% in Pap smear, 53.7% and 85.2% in cervicography, and 57.8% and 80.6% in HPV test, respectively. The combination of Pap smear with cervicography or with HPV test for detecting CIN 1 or above had same SE and SP of 89.1% and 62.0% respectively. The combination of cervicography and HPV test had SE of 78.9% and SP of 70.4%. Three methods combination showed 93.9% SE and 54.6% SP. The estimated cost per method was highest in three methods combination (117,000 won) and lowest in Pap smear alone (12,000 won). The cost for detection of one case of cervical neoplasia was highest in combination of cervicography and HPV test (241,907 won) and lowest in Pap smear alone (25,385 won). CONCLUSION: The combinations of each method showed increased SE. These combinations, however, had low SP and high cost than individual method. Cervicography or HPV test alone should not be considered as an alternative to Pap smear for cervical cancer screening because its cost-effectiveness is not significantly better than that of Pap smear.
Cervical Intraepithelial Neoplasia ; Diagnosis ; Early Detection of Cancer ; Female ; Humans ; Korea ; Mass Screening* ; Sensitivity and Specificity ; Seoul ; Uterine Cervical Neoplasms

No abstract available.
*Colposcopes ; Early Detection of Cancer/*instrumentation ; Female ; Humans ; Optical Imaging/*instrumentation ; Uterine Cervical Dysplasia/*diagnosis ; Uterine Cervical Neoplasms/*diagnosis

Recently, a number of evidences that human papillomavirus (HPV) testing was efficient in cervical cancer screening were introduced. Moreover, successful trial outcome of preventive cancer vaccine opened new era of cervical cancer prevention. However, undoubtedly, applying new cancer screening and prevention strategy would bring on economical concern about increased medical expense. Therefore, appropriate cost-benefit analysis is very important before establishing new strategy as standard policy. In this article, we presented a few recent results about cost-benefit effectiveness by other group. And we also suggested what would be needed to perform successful.
Cost-Benefit Analysis ; Early Detection of Cancer ; Humans* ; Mass Screening ; Uterine Cervical Neoplasms

Multiple primary cancer means that more than two cancers are independently developed in one individual. The frequency of multiple primary neoplasm is increasing as a result of the lengthening average lifetime, progress in cancer screening technique, and improved cancer therapy. Gynecologic malignancies are especially prone to associated with primary neoplasms elsewhere. The frequency of multiple primary cancers was significantly higher in patients with uterine corpus cancer than in those suffering from cervical cancer. This case has different cell types of cancer in uterine cervix, thyroid and colon simultaneously. So, we report the case with a brief review of literatures.
Cervix Uteri ; Colon ; Early Detection of Cancer ; Female ; Humans ; Neoplasms, Multiple Primary ; Thyroid Gland ; Uterine Cervical Neoplasms

Cervical cancer is a complex disease caused by both genetic susceptibility and environmental factors. Inherited genomic variance, high-risk human papilloma virus (HPV) infection/integration, genome methylation and somatic mutation could all constitute one machine learning model, laying the ground for molecular classification and the precision medicine of cervical cancer. Therefore, for cervical screening, next generation sequencing (NGS)-based HPV DNA and other molecular tests as well as dynamic machine learning models would accurately predict patients with potential to develop the cancer, thereby reducing the burden of repeated screening. Meantime, genome-editing tools targeting HPV would emerge as the next generation gene therapy for HPV-related cervical lesions. In this article, we review the substantial progress on molecular mechanism of cervical cancer development and suggest the future for precise prevention and early treatment of cervical cancer.
Early Detection of Cancer ; Female ; Humans ; Mass Screening ; Papillomaviridae ; Uterine Cervical Neoplasms ; diagnosis ; prevention & control ; therapy ; virology

The advent of the digital era brings new challenges and opportunities for cervical cancer prevention and research.With the development of digital techniques in China,the construction of an information platform for cervical cancer prevention based on the current achievements has become an important trend.This paper expounds the importance,existing problems,and challenges of the data integration of population-based cervical cancer screening and the information platform construction,and puts forwards effective measures to promote its construction.The establishment of an information platform for cervical cancer prevention in the digital era has far-reaching significance for the global elimination of cervical cancer.
China ; Early Detection of Cancer ; Female ; Humans ; Uterine Cervical Neoplasms/prevention & control*