Objective To compare the outcomes of two temperature maintenance strategies during radical resection for carcinoma of oesophagus and their effects on postoperative shivering. Methods Thirty ASA Ⅰ-Ⅱ patients undergoing radical resection for carcinoma of oesophagus were randomly assigned to hypothermia group (HT group, patients were not wanned perioperatively, n=10), intraoperative normothermia group (INT group, patients were warmed only intraoperatively, n=10) and perioperative normothermia group(PNT group, patients were warmed before induction of anesthesia and during anesthesia, n=10). The tympanic temperature began to be recorded 20 min before induction of anesthesia at intervals of 10 min. Results There was no significant difference in the decrease velocity of tympanic temperature during the first hour after induction of anesthesia between HT group and INT group, while both were significantly higher than that of PNT group (P<0.05). There was no significant difference in the tympanic temperature within 70 min after induction of anesthesia between HT group and INT group, while both were significantly lower than that of PNT group (P<0.05). The tympanic temperature of HT group continued to decrease 70 min after induction of anesthesia, while that of INT group and PNT group began to increase. There were significant differences in the tympanic temperature 80 min to 180 min after induction of anesthesia among these three groups(P<0.05). The incidences of postoperative shivering were 8, 5 and 2 in HT group, INT group and PNT group, respectively. The scores of thermal comfort scale were 19±10, 41±7 and 51±11 in HT group, INT group and PNT group, respectively, and there were significant differences among these three groups(P<0.05). Conclusion Compared with INT, PNT can more effectively maintain perioperative normothermia, reduce the incidence of shivering and relieve the patients' cold thermal discomfort in radical resection for carcinoma of oesophagus.

Child ; Humans ; Kidney Diseases ; etiology ; pathology ; Precursor Cell Lymphoblastic Leukemia-Lymphoma ; complications ; diagnosis

Objective To investigate the effect of intraoperative hypothermia and warming on hemostasis using thromboelastography(TEG)during radical esophagus cancer operation performed under general anesthesia combined with thoracic epidural block.Methods Sixteen ASA Ⅰ or Ⅱ patients undergoing elective radical esophagus cancer operation were randomly allocated to one of two groups(n=8 each):control group and warming group.The patients were unpremedicated.The operating room temperature was set at 21℃.Epidural catheter was placed at T_(7,8) and advanced 4 cm into epidural space.Correct epidural placement was confirmed by a test dose of 4 ml 1% lidocaine.0.375% bupivacaine was used during operation.General anesthesia was induced with fentanyl,thiopental and succinylcholine and maintained with isoflurane inhalation and intermittent i.v.boluses of vecuronium after endobronchial intubation with double lumen catheter.The patients were mechanically ventilated (V_T=8-10 ml?kg~(-1),RR=10-12 bpm,I:E=1:2,FiO_2=100%).In warming group TC-2000 wanning system (Thermacave,USA)was used.The lower part of the body was warmed for 45 min before induction of anesthesia (temperature was set at 38℃).After induction warming was continued(temperature was set at 43℃).In control group no wanning was provided.The fluid infused during operation was all warmed to 37℃.Tympanic temperature measurement was started from 20 min before induction and recorded every 10 min afterwards.TEG was performed before induction of anesthesia(T_0) and at 150 min after induction(T_1).The blood samples were divided into 2 aliquots of which one was tested at 37℃ and the other at patient's actual core temperature.Results The two groups were comparable with respect to age,sex,body weight duration of operation and the amount of fluid infused during operation.At T_1 the tympanic temperature was 34.7?0.4℃ in control group and 36.5?0.3℃ in warming group.At T_1 in control group the reaction time(R)and clot formation time(K)were significantly prolonged and a angle was significantly reduced when TEG was measured at core temperature compared with those measured at 37℃ (P＜0.05).At T_1 when TEG was measured at core temperature R and K were significantly shorter and a angle was significantly wider in warming group than in control group (P＜0.05).There was no significant difference in MA between the two groups at T_1.Conclusion Mild hypothermia developed during operation can impair bemostasis.Maintenance of normal body temperature(core temperature)during operation is necessary.

Lichen planus of mouth is a kind of mucosal disease,it's more common in the elderly and has longer course. This article is to introduce Dr. ZHAO Bing-nan's unique experience in treating lichen planus of mouth through harmonizing the imbalance between yin and yang with herbs of vine,flowers and carbo. Based on syndrome differentiation,other methods are used,such as clearing method,warming method,tonifying method,and drugs of promoting blood flow,promoting granulation and astringing are used locally.

Objective To evaluate the clinical efficacy and safety of Chushi pellets in patients with subacute eczema of more dampness less heat type.Methods A randomized,double blind,double-dummy and positive parallel-controlled study was performed.Totally,129 patients with subacute eczema were collected at the dermatology clinic in Beijing Hospital of Traditional Chinese Medicine from May 2010 to October 2011,and classified into two groups to be treated with Chushi pellets and placebo capsules (n =66,experiment group) or Shiduqing capsules and placebo watered pills (n =63,control group) for 4 weeks.Follow-up visits were scheduled on day 1 (baseline),and 4 weeks after the beginning of treatment.Clinical endpoints included skin rash area,color,morphology,degree of pruritus and laboratory examination results.The therapeutic effect and safety of Chushi pellets were evaluated.The differences in clinical parameters were assessed by using t test and Wilcoxon rank-sum test between pre-and post-treatment,and by Pearson chi-square test or Fisher's exact test between the experiment and control group.Results Finally,the treatment outcome of 123 patients were assessed for the efficacy of Chushi pellets.At the end of the treatment,the total response rate was 69.3％ (43/62) in the experiment group,and 59.0％ (36/61) in the control group (x2 =1.43,P ＞ 0.05).The improvement in pruritus was greater in the experiment group than in the control group (x2 =4.05,P ＜ 0.05).Side effects mainly included loose stool and stomach upset,with an incidence of 13.6％ (9/66) in the experiment group,and 11.1％ (7/63) in the control group.No marked changes were observed in laboratry parameters after treatment in either of the groups.Conclusions Chushi pellets are safe and effective for the treatment of subacute eczema of more dampness less heat type.Compared with Shiduqing capsules,Chushi pellets shows an equivalent overall efficacy but a stronger antipruritic effect.

?Dry eye is a multi-factorial disease of tear film and ocular surface, and it can result in discomfort, visual disturbance and tear film instability and potential damage of ocular surface, accompanied by hyper osmolarity of tears and ocular surface inflammation. lnflammation is the key factor to dry eye. Many kinds of immune cells and inflammatory factors are involved in the occurrence and development of dry eye syndrome. Cell apoptosis, nerve dysregulation, disorders of sex hormones also play an important role in pathologic process of dry eye. Recently, while illustrating the pathophysiology and pathogenesis of dry eye has been made some progress, there is still no single standard. The possible mechanisms of ocular surface inflammation and tear dysfunction of dry eye were reviewed in this article.

Objective To prohc into the distinguished feature of postoperation of early inflammatory intesti- nal and the principle of diagnosis and treatment.Methods 23 cases of early intestinal postoperatively treated during the year of 2003 to 2005 were analysed.Results In the 23 cases,20 of them were treated conservatively while 3 of them were treated operatively,both of which were recovered and dischanged from hospital.Conclusion The early inflammatory intestinal postoperatively is a kind of special one in which both mechanical factor and dynamic factor could be found.Most of the patients could be cured by conservative way and they should surely be in closed observa- tion of the condition in order to be handled properly.

Objective To clone the R2R3 MYB transcription factor gene SmMYB87 in subgroup 14 from Salvia miltiorrhiza, and analyze the bioinformatics and expression of this gene. Methods Total RNA extracted from S. miltiorrhiza was used as cDNA synthesis template and the full length cDNA sequence was obtained through homology-based cloning and rapid amplification of cDNA ends (RACE) technology. The structure and physicochemical properties of SmMYB87 gene and its coded protein were analyzed with bioinformatics softwares. The expression of SmMYB87 in different organs was determined with qRT-PCR, and a GFP fusion expression vector was constructed to investigate the subcellular laicization of SmMYB87 protein. Results SmMYB87 gene contained two introns and an open reading frame (ORF) of 732 bp, encoding 243 amino acid polypeptides. It expressed in roots, stems, leaves and flowers with similar expression levels and the SmMYB87 protein located in nucleus and cytomembrane. Conclusion The analysis of sequence structure and expression pattern of SmMYB87 will be helpful to study the regulating roles of this gene in S. miltiorrhiza.