OBJECTIVE:To implement GPP persistently and consolidate the authentication result of GPP.METHODS:We introduced the specific ways for the strengthened management of production & quality in manufacturing department of our hospital after the introduction of GPP authentication.RESULTS & CONCLUSIONS:Due to the improvement and practice of GPP file system,the production & quality management level was perfected and transition from human-oriented management to text management was achieved.On-line monitoring of production and quality management of preparations were strengthened by means of internal microcomputer network.Staff's enhanced cognition level on GPP facilitated the effective and comprehensive implementation of GPP throughout production,management,storage and distribution of preparations.Hence,effective and persistent GPP management has been realized in manufacturing department of our hospital.