Objective To study the efficacy of insulin pump therapy for type 2 diabetes and its impact on quality of life.Methods 60 patients with type 2 diabetes were selected and divided into A group and B group according to a random number table,30 cases in each group.The patients of B group were given conventional therapy,and which of A group was treated with insulin pump.The fasting plasma glucose,0.5h fasting blood glucose and 2h postprandial blood glucose were measured and compared before and after treatment,the quality of life was evaluated by quality of life scale(QOL),the QOL score before and after treatment between two groups was compared.Results The fasting plasma glucose,0.5h fasting blood glucose and 2h postprandial blood glucose of A group after treatment were (5.69 ±0.19)mmol/L,(5.28 ± 1.03) mmol/L and (7.31 ±2.14) mmol/L,respectively,which were significantly lower than (6.72 ± 2.04) mmol/L,(6.39 ± 1.69) mmol/L and (9.72 ± 1.57) mmol/L of B group (t =9.798,10.023,9.971,P =0.035,0.027,0.032) ; The QOL score of the group A was (78.4 ± 0.8) points,which was significantly better than that before treatment (t =9.064,P =0.023),and better than that of group B (t =10.853,P =0.019).Conclusion Insulin pump has better clinical efficacy in the treatment of type 2 diabetes compared with conventional therapy,it can effectively control blood sugar and improve the quality of life of patients.

The chemosensitivity enhancive mechanism on nitric oxide includes three routes:adjust the expression level of hypoxia-inducible factor-1 α(HIF-1 α),classical nitric oxide signal pathway and combine with the reaction products of other molecules.Traditional nitric oxide donor compounds include nitroferricya-nide,organic nitrates,s-nitrosothiols,azo onium diol aldoxide,non-steroids anti-inflammatory drugs,whose function of antitumor and chemotherapy sensitization caused extensive attention.

Objective To discuss the influence of H1N1 influenza on maternal and fetal outcomes and obstetric management. Methods Totally, data were collected on 19 women, affected by H1N1 influenza and admitted to Shengjing Hospital of China Medical University from November 7, 2009 to December 15,2009, and retrospective analysis was performed on the maternal and fetal outcomes. Results Among the 19 cases, three were( 15. 8%, 3/19) in puerperium, who were all mild cases and recovered. Sixteen (84.2%, 16/19)women were diagnosed as H1N1 influenza during pregnancy, among which two in early pregnancy (12. 5%), seven (43. 8%) in mid-term pregnancy and seven (43. 8%) in late pregnancy. According to the severity of H1N1 influenza, six were mild cases (37. 5% ,6/16), two (12. 5% ,2/16)were severe cases and eight (50. 0% ,8/16)were critical. For these 16 pregnant women, thc two cases in early pregnancy (mild cases) were terminated after recovery from H1N1 influenza. Among the seven mid-term cases, four mild and one of the three severe and critical cases delivered till term, and two of the three severe and critical cases were delivered abdominally because of fetal death intrauterine or maternal severe complications at 27 or 23 weeks of gestation. All of the seven late pregnant cases underwent emergent cesarean section due to maternal or fetal reasons, and two fetuses died in the uterus at late pregnancy and five survived including four preterm babies and one full term baby. Altogether, nine cases (56. 3%, 9/16)underwent emergent cesarean section, and six babies born alive and five survived without any symptom of influenza, two women died (10. 5%,2/19) after the operation. Conclusions Pregnant women during late pregnancy infected by H1N1 influenza are susceptible to develop into severe and critical conditions. Termination of the pregnancy in time is effective in both life-saving of the mothers and babies and prevent neonatal infection against H1N1.

Objective to analyze the influence obstetric factors of the small for gestational age(SGA)in twins,so as to direct the clinical prenatal supervision in clinic. Methods A retrospective study of the SGA was performed,the general data of 1 514 patients admitted in obstetrics and gyne-cology of Shengjing Hospital during 2001 to 2014 were analyzed by Logistic regression analysis. Results the incidence of the SGA in twins was 10.89%. the protective factors were male fetus,assisted reproductive technology(ARt)and gestational diabetes mellitus(GDM). the risk factors were the female fetus and hypertensive disorders in pregnancy. Conclusion the gender of fetus,assisted reproductive technology(ARt),gestation-al diabetes mellitus(GDM),hypertensive disorder complicating pregnancy are the influential factors of the SGA in twins. We recommend a further pre-pregnancy and pregnancy care which is of significance for the prevention of SGA.

TBX20 gene, a member of the T-box gene family, plays an important role during heart development and is required for maintaining adult heart function.TBX20 can act as both transcriptional activator and transcriptional suppressor during the development of the heart, and shows complex spatiotemporal regulation.TBX20 is an important candidate transcription factor for the pathogenesis of congenital heart disease(CHD), and its mutation or expression change can lead to the occurrence of CHD.In this paper, the latest research progress of TBX20 gene in the field of heart development is reviewed from the relationship between TBX20 and CHD, the signaling pathway involved in heart development and its interactions with other cardiac transcription factors.

Objective: To establish an HPLC method for the determination of luteolin-7-O-glucoside in Sedum Sarmentosum Bunge. Methods:The chromatographic column was Waters SymmetryShield C18(250 mm ×4.6 mm,5μm). The mobile phase consis-ted of tetrahydrofuran-methanol-water-phosphoric acid (9 ∶17 ∶74 ∶0. 25). The flow rate was 1. 0 ml·min-1. The detection wave-length was 350 nm. The chromatographic column temperature was 35℃. The injection volume was 10 μl. Results: The calibration curves were linear within the range of 5. 2-208. 0 μg · ml-1 ( r =0. 999 9 ) for luteolin-7-O-glucoside. The average recovery was 99. 12%(RSD=0. 94%,n=6). Conclusion:The method is simple, rapid, accurate, specific and repeatable. It can be used for the determination of luteolin-7-O-glucoside in Sedum Sarmentosum Bunge.

A 61 year-old male patient, plasma fibrinogen level was 2.98 g/L, endoscopic sinus surgery was performed under general anesthesia for polypoid of uncinate process with mycotic maxillary sinusitis. Hemocoagulase were given in pre- and post-operative for treatment. The patient was found postoperative drain blood continuously since 3 days after surgery, when the dose of hemocoagulase reach 26 KU, and fibrinogen determined in Plasma was 0.48 g/L. Coagulation returned to normal and nasal bleeding stopped after discontinuation of the hemocoagulase and supplement with fibrinogen.
Batroxobin ; adverse effects ; Blood Coagulation Disorders ; chemically induced ; Endoscopy ; adverse effects ; Fibrinogen ; analysis ; Humans ; Male ; Middle Aged ; Nasal Surgical Procedures ; adverse effects ; Paranasal Sinuses ; surgery

Objective To investigate the clinical value of para-aortic lymphadenectomy in patients with cervical cancer in stage Ⅰ B2 and Ⅱ A2.Methods One hundred and six patients with cervical cancer in stage Ⅰ B2 and Ⅱ A2 were assigned into two groups:control group(55 patients,radical hysterectomy and pelvic lymphadenectomy) and study group (51 patients,radical hysterectomy,pelvic lymphadenectomy and para-aortic lymphadenectomy).Postoperative radiotherapy or chemotherapy was conducted appropriately.Intraoperative and postoperative characteristics,recurrence rate,survival rate were compared between two groups.Results In study group,the recurrence rate was 15.7 ％ (8/51),and in control group,the recurrence rate was 38.2％(21/55),there was significant difference (P ＜ 0.05).No significant difference were observed in the complication incidence [27.5％ (14/51) vs.30.9％ (17/55)],blood loss [(326.1 ± 59.1) ml vs.(316.1 ± 51.2) ml] and pelvic lymph node-positive rate [56.9％ (29/51) vs.58.2 ％ (32/55)](P ＞ 0.05).The incidence of para-aortic lymph node metastasis was 17.6 ％ (9/51).Positive correlation was observed between the number of the pelvic lymph node metastasis and para-aortic lymph node metastasis (P ＜ 0.01).Conclusions In cervical cancer,the number of the pelvic lymph node metastasis was associated with para-aortic lymph node metastasis,abdominal aortic lymphadenectomy in radical surgery for cervical cancer is safe and feasible and can improve the prognosis of the patients.

Objective To evaluate the prognosis and safety of long-term oral Branched-Chain Amino Acids (BCAAs) for patients with cirrhosis.Methods Randomized controlled trials (RCTs) were identified from CBM (between January 1978 and September 2013),CNKI (between January 1979 and September 2013),PubMed (between January 1970 and September 2013),EMBASE (between January 1970 and September 2013),and Cochrane Library (issue 4,2013).Publications of the RCTs on the treatment of cirrhosis with oral BCAAS were included and analyzed according to the criteria of Cocbrane handbook.Results Six RCTs involving 1 047 patients were included.The results showed that oral BCAAs improved the event-free survival when compared with the control group [RR =1.13,95％ CI =(1.05,1.23),P =0.001].BCAAs supplements had no effect on mortality or had no definite effect on the deteriorative rate of minimal hepatic encephalopathy (MHE) or quality of life (QOL).As reported in some trials,the main side effects of BCAAs were gastrointestinal symptoms.Conclusions Long-term oral BCAAs may improve event-free survival in cirrhotic patients.However,no definite conclusion can be made without evidences from larger,randomized,double-blind,placebo-controlled,and multicenter trials.

The root canals of 95 maxillary second primary molars were explored by 10#file combined with 17%EDTA.The canal orifice was observed and orientated by endoscope.Hand instruments were used for root canal preparation and screw conveyor was used to fill the ca-nal with Vitapex paste.MB2 was found in 14 of the 95 molars(14.7%).MB2 orifice was usually located mesially along MB-P.