Objective In order to know the nursing points for patients with obstructive azoospermia when cured by testicular sperm extraction combined with intracytoplasmic sperm injection. Methods Summurized the nursing pionts from nine patients with obstructive azoospermia when cured by testicular sperm extraction combined with intracytoplasmic sperm injection. The main nursing cares inclued peri-operative nursing points, psychological nursing and fellow up. Results All the nine patients had TESE successful and enter the ICSI period without any complication. There was a newborn had deliver-ied successfully. Conclusions Positive psychological nursing, careful perioperative nursing cares and counter preventive measures are the guarantee for smoothly operation and postoperative rehabilitation.