Objective To inverstigte the feasibility of video-assisted thoracoscopic surgery(VATS) be used in grass-roots hospital. Methods 46 patients were treated with video-assisted thoracoscopic surgery or video-assisted minithoracotomy surgery (VAMT) including bullectomy, lobectomy or wedge resection of lung, lung volume reduction surgery, esophageal tumor resection, clearance of hemathorax,partial pericardial,et al. Results There was no operative mortality. Complications occurred in 2 cases(4.3%). All patients were perfectly recovered by treatment. The overall follow-up was 6 months. Conclusion VATS is a safe,effective and new technique of thoracic surgery. More attentions must be payed to prevent and reduce complication in order to generalize the use of grass-roots hospital.

Objective To observe the effect of Shengeyifei capsule on the inflammatory mediators in the airway and the pathology of the airway in the rat with chronic obstructive pulmonary diserse (COPD). Methods 60 SD rats were divided randomly into normal group, COPD model group, Jinshuibao control group and Shengeyifei groups. The COPD model was established by smoking and infusing lipopoly- saccharide (LPS). The level of interleukin-8 (IL-8) and tumor necrosis factor ? (TNF-?) in bronchoalveolar lavage fluid (BALF) were measured and the pathology of the airway and lung tissue was observed after treatment on the rats. Result The levels of IL-8 and TNF-? in Shengeyifei groups were lower than in COPD model group (P

Objective To compare the efficacy and safety of icotinib therapy alone versus icotinib combined with thoracic radiotherapy for the treatment of advanced non-small cell lung cancer (NSCLC) patients with an activating epidermal growth factor receptor (EGFR) gene mutation.Methods A total of 83 patients with advanced NSCLC harboring an activating EGFR gene mutation was enrolled in this study.All the patients were randomly divided into 2 groups.Patients in group A (n =41) received thoracic radiotherapy (prescribed at 60-66 Gy) combined with icotinib (three times per day,125 mg once).Patients in group B (n =42) were given icotinib therapy alone (three times per day,125 mg once).Treatment was continued until disease progression or unacceptable toxicity or death.The primary end points were median progression-free survival (mPFS) and 12 month-PFS rate.The secondary end points included objective response rate (ORR),disease control rate (DCR) and adverse events.Results With a median follow-up of 18.2 months,mPFS was 15.2 months (95％ CI:12.2-17.4) in group A and 13.2 months (95％ CI:10.8-14.9) in group B (x2 =4.29,P=0.036).PFS rates of 12 months for group A and group B were 70.3％ and 61.2％,respectively.The ORR were 78.0％ vs.57.1％ (x2 =5.16,P =0.028),and the DCR were 95.1％ vs.92.9％ (P＞0.05) in groups A and group B,respectively.No grade 3-4 adverse events was observed in both groups except the rashes (4 cases in each group).Besides,10 patients had grade 1-2 radiation-related pneumonitis and 15 patients suffered grade 1-2 radiation-related oesophagitis in group A.Conclusions In advanced NSCLC patients with an activating EGFR gene mutation,the combination of thoracic radiotherapy and icotinib had achieved an improvement on ORR and PFS with good tolerance.Clinical trial registration Chinese clinical trial registry,ChiCTRINR-16010262.

Malignant neoplasm recurrence is the most important prognostic factor for patients.Looking for tar-get gene is an important part of cancer research.Annexin Ⅰ (ANXA1 )is to be discovered in the seventies century, composition by 13 calcium -phospholipid binding proteins annexin superfamily members of the first molecules. ANXA1 expressed in a variety of malignant tumors,ANXA1 expression levels were significantly reduced or absent in most tumor tissues.The study found that changed ANXA1 expression in tumor cells may have a causal relationship with the malignant phenotype of tumor cells.This paper aims to investigate the relationship between annexin Ⅰ and malignant neoplasm metastasis.

Aim To explore the anti-proliferation effects of curcumin trinicotinate ( CurTn ) on vascular smooth muscle cell ( VSMC ) and its mechanism. Methods The cells were cultured in DMEM supple-mented with 10% fetal bovine serum. MTT assay was used to examine cell proliferation. FCM was used to observe cell cycle. The expressions of PCNA, Cy-clinD1 and p-ERK1/2 were analyzed using Western blot. Results CurTn could inhibit the proliferation of VSMC and showed a certain amount-time relationship. What’ s more, CurTn could increase the G1 phase pro-portion of cell, decrease the S phase proportion and the expression level of PCNA protein. It was also found that CurTn significantly inhibit the protein expression of p-ERK1/2 and Cyclin D1 . Conclusion CurTn may inhibit the proliferation of VSMC via downregulating the expression of CyclinD1 and p-ERK1/2 .

Objective To investigate the efficacy and safety of whole brain radiotherapy combined with ectatinib hydrochloride in the treatment of non-small cell lung cancer (NSCLC) brain metastases. Methods A total of 44 patients with brain metastases from NSCLC from June 2013 to June 2017 were randomly divided into combination therapy group and radiotherapy group. The efficacy and safety between the two groups were compared. Results The median follow-up was 18.5 months. The mPFS of the combination therapy group and the radiotherapy group were 9.3 months and 6.6 months, respectively (log-rank P=0.006). The mPFS of the EGFR mutant and wild type in the combination group were12.2 months and 6.5 months (log-rank P=0.002). The mPFS of EGFR mutants and wild-type patients in the radiotherapy group were 6.4 months and 6.8 months, respectively (log-rank P=0.933). The mOS in the combination therapy group and the radiotherapy group were 14.2 months and 12.6 months, respectively (log-rank P=0.035). The mOS of the EGFR mutant and wild type in the combination group were 19.1 months and 12.7 months, respectively (log-rank P=0.006). The mOS of EGFR mutants and wild-type patients in the radiotherapy group were 12.6 months and 10.4 months, respectively (log-rank P=0.449).The ORR of the two groups was 78.3％ and 47.6％, respectively (log-rank P=0.035), and the DCR was 91.3％ and 85.7％, respectively (χ2=0.341, P=0.560).In terms of adverse reactions, the incidence of rash in the combined group was 56.5％, of which 3 cases were grade 3-4. The adverse reactions such as fatigue, nausea and vomiting, diarrhea, liver and kidney damage, and leukopenia were all grade 1-2, and there was no statistically significant difference between the two groups. Conclusion Ectinib hydrochloride combined with whole brain radiotherapy can improve the objective response rate of patients with non-small cell lung cancer with brain metastases, prolong the median local progression-free survival and median overall survival, and the patient's adverse reaction tolerance is good.

Objective:To observe the clinical efficacy of vascular intervention in the treatment of uterine scar pregnancy after cesarean section .Methods:A total of 50 patients with uterine scar pregnancy after cesarean section were selected and randomly divided into observation group and control group ,with 25 patients in each group .The patients in the control group were treated with dilatation and curettage , while the patients in the observation group were treated with uterine artery embolization combined with curettage with methotrexate .After treatment ,the clinical efficacy ,the blood loss ,the time of serum β‐human chorionic gonadotropin (β‐HCG) returning to normal level ,the time of endo‐uterine mass disappearing ,the patient's hospital stay and adverse effects ,were compared between the patients in the two groups .Results:The cure rate of patients in the observation group (100% ) was significantly higher than that (64% ) in the control group(P<0 .05);the blood loss (47 .1 ± 14 .2)mL ,the time of endo‐uterine mass disappearing (23 .6 ± 23 .7) d and hospital stay (13 .2 ± 4 .3) d of patients in the observation group were significantly lower than those in the control group [(322 .1 ± 105 .2) mL ,(80 .4 ± 78 .3) d ,(20 .1 ± 7 . 8)d ,P<0 .05)];there was no occurrence of severe complications in the two groups .Conclusions:Vascular intervention in the treatment of uterine scar pregnancy after cesarean section can effectively kill the embryo tissues ,reduce the blood loss ,and retaln the womb as well as the fertility .

Objective:To explore the effects of Baduanjin combined with staged rehabilitation exercise in patients after percutaneous transforaminal endoscopic discectomy (PTED) .Methods:From May 2018 to May 2019, convenience sampling was used to select 141 patients after PTED admitted to Zhoushan Hospital of Traditional Chinese Medicine in Zhejiang Province as the research objects. According to the random number table, patients were divided into Baduanjin group, staged rehabilitation exercise group and combined group, with 47 cases in each group. Baduanjin group implemented the Baduanjin intervention on the basis of conventional nursing, staged rehabilitation exercise group was given the rehabilitation exercise intervention on the basis of conventional nursing, and combined group carried out the Baduanjin combined with staged rehabilitation exercise intervention on the basis of conventional nursing. The Japanese Orthopaedic Association Scores (JOA) , Oswestry Disability Index (ODI) and the Rehabilitation Exercise Compliance Scale were used to assess patients' rehabilitation exercise status. During the course of the study, five subjects withdrew from the study, including one in combined group, three in Baduanjin group, and one in staged rehabilitation exercise group.Results:A total of 90 days after the intervention, the JOA score of combined group was higher than that of Baduanjin group and staged rehabilitation exercise group, and the ODI score was lower than that of Baduanjin group and staged rehabilitation exercise group, the differences were statistically significant ( P<0.05) . The total compliance rate of rehabilitation exercise in combined group was higher than that in Baduanjin group and staged rehabilitation exercise group, and the difference was statistically significant ( P<0.05) . Conclusions:The scientific and reasonable intervention of Baduanjin combined with staged rehabilitation exercise for lumbar disc herniation patients after PTED can not only effectively increase the patient's comfort and compliance with rehabilitation exercises, but also effectively improve patient dysfunction and low back pain. It has high clinical application and promotion value.

Objective To study the application of preoperative assessment of record sheet on surgical patients in neurosurgery department .Methods Totals of 80 surgical patients were randomly divided into observation group and control group .Patients in observation group were given preoperative assessment record sheet, and patients in control group were given routine preoperative visit .The curative effect and postoperative nursing effects were compared .Results The intraoperative blood loss , operative time , length of hospital stay and patients increasing blood pressure in observation group were (268.88 ±38.38) ml, (142.1 ±10.10) min, (12.88 ±0.56) days,2, respectively, which were significantly lower than (407.50 ±54.05)ml, (178.40 ± 11.83)min, (25.63 ±1.02) days, 8 in control group.The differences were statistically significant (t=2.176, 2.288,10.960, respectively; χ2 =4.114;P <0.05).HAMA and HAMD scores of patients in observation group after operation were (10.42 ±2.64),(9.44 ±2.65),respectively, which were lower than (13.53 ±4.63), (12.32 ±2.44) before operation, and lower than (13.12 ±3.34),(11.82 ±2.54) in control group after operation too, the differences were statistically significant (t=3.043,3.856,3.544,2.643, respectively;P<0.05).Patient satisfaction scores was (7.64 ±1.65) and the number of satisfied patients was 23 in observation group, which were significantly higher than (6.55 ±1.63) and 14 in the control group.The differences were statistically significant difference (t=3.643,Z=4.073;P<0.05).Conclusions Neurosurgery patients with preoperative assessment can better improve the patient ’ s emotional impact , the curative effect of surgical treatment and reduce the risk of intraoperative complications .