OBJECTIVE To study the distribution of pathogens and the extent of drug resistance in surgical incision infection,and offer the first-hand information to the clinical preventive and therapeutic countermeasures.METHODS Totally 309 in-hospital patients were investigated retrospectively.RESULTS A total of 210 pathogens strains were cultured from the secretion of surgical incision infection.The dominating microorganisms were Escherichia coli,Staphylococcus aureus,Klebsiella pneumoniae and Pseudomonas aeruginoa.Among them,54 strains of ESBLs,12 strains of anti-IPM bacteria,15 strains of MRSA and 8 strains of MRCNS producing bacteria were detected.The result showed,vancomycin and imipenem still had better activities to the bacteria.CONCLUSIONS Surgical incision infection should be attached importance to.It is time to take some effective measures to supervise and control bacterial resistance.