The antitumor effect of sodium morrhuate (SM ) and cis - diaminoaichloroplatinum (CDDP ) for gastric cancer cell SGC - 7901 in vitro is observed with MTT assay. Human gastric cancer cells line SGC - 7901 were inoculated subcutaneously in the naked mice , so xenografts were established. The tumor of the mice in the combination groups were cross injected with SM 50mg . kg~(-1) . time~(-1) , 50?l and CDDP ( 3mg ? kg~(-1)? time~(-), 50?l)in varying order at an interval of 30 minutes. In each mouse the tumors were injected every third davs for a total of three injections. lt was found SM had strong antitumor effect on gastric can- cer cells in vitro experiment. The antitumor effect of local injection in combination groups were much stronger than that in any other single drug groups. The histopathological section observation showed that all tumors cells were necrotic in combination groups, There could be seen fibrous histocysts around the . necrotic tumor tissue in observation groups , and necrotic vascular endotheliocytes. The experiment showed that combined injection with SM and CDDP had a synergic antitumor effect.

Heatstroke is a critical disease which usually catches in the hot environment in summer and abundant exercise that could bring about multiple organ dysfunction.The process of the occurrence and development of heatstroke includes of the compensatory phase,acute reaction stage and decompensation stage.The recent researches have shown that the mechanism of liver injury induced by heatstroke might be related to the direct action of heat,mitochondrial dysfunction in liver cells and cascade of inflammatory response,and each link promoted each other,finally caused liver injury.In addition,a cascade of inflammatory responses in the hepatic sinusoid might play a predominant role in liver injury induced by heatstroke.This paper aims to review the mechanism of liver damage caused by heatstroke in terms of the physiology and pathology,so as to provide perspectives for clinical prevention and treatment of liver injury.