1.Analysis of infection after cesarean section
Haizhen ZHENG ; Caifei CHEN ; Hai HONG
Journal of Endocrine Surgery 2015;(3):227-229
Objective To analyze the causes of infection after cesarean section.Methods 80 patients having infection after cesarean section from Jan.2008 to Jan.2013 in our hospital were studied.The clinical data were retrospectively analyzed.The nosocomial infection-related factors were observed and related factors were ana-lyzed by Logistic regression analysis.Results 80 cases of maternal infection occurs after cesarean section.The highest rate of infection was urinary tract infection and respiratory infection, accounting for 43.75%and 31.25%respectively.We found the possible factors related to infection after cesarean section induding operative time, the number of invasive procedures, premature rupture of membranes, and the use of antibiotics.Conclusions Knowing the factors related to infection and improving the operative skills of gynecologists can help to reduce the rate of infection after cesarean section.
2.Progress of research on Maple syrup disease.
Caifei YANG ; Tao CHEN ; Xiaoguang LEI ; Yuexian LIU ; Mengyuan XU ; Dan YANG
Chinese Journal of Medical Genetics 2019;36(7):737-741
Maple syrup disease (MSUD) is a rare autosomal recessive disorder caused primarily by mutations of branched-chain keto acid dehydrogenase complex (BCKDC). BCKDC includes at least four pathogenic genes of BCKDHA, BCKDHB, DLD and DBT. The clinical manifestations of MSUD are complex, and the main symptoms at the early stage include difficulty in feeding, drowsiness, change in muscle tone and special urine flavor of maple syrup. As the disease progresses, convulsion, hypoglycemia, coma and systemic failure may occur. MSUD is easily missed or misdiagnosed during the neonatal period. This paper provides a review for recent progress made in research on MSUD including etiology, physiopathology, clinical manifestation, auxiliary examination and treatment, with a particular emphasis on genetic testing and treatment.
3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide)
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genetics
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Humans
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Maple Syrup Urine Disease
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diagnosis
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genetics
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therapy
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Mutation
3. Research progress on the effect of rhythmic sensory cueing on motor function of Parkinson′s disease
Mengyuan XU ; Tao CHEN ; Yuexian LIU ; Caifei YANG ; Qingyun PENG ; Dan YANG ; Xiaoguang LEI
Chinese Journal of Neurology 2020;53(1):72-78
Oral medicine and deep brain stimulation are two main treatments for Parkinson′s disease (PD). But their long-term efficacies are decreasing, which limit the choice of patients in advanced stage. As a special way of sensory intervention, rhythmic cueing can improve gait parameters, reduce freezing of gait severity and improve gait-related mobility by activating the motor pathway directly, repairing internal clock, promoting internal dopamine release and improving cognitive function to maintain gait stability. Rhythmic auditory and visual cueing has a potential in PD treatment.
4.Progress on quantitative assessments of motor symptoms for Parkinson′s disease
Mengyuan XU ; Tao CHEN ; Xu MENG ; Yuexian LIU ; Caifei YANG ; Xiaoguang LEI
Chinese Journal of Neurology 2020;53(10):845-854
Clinical scales and external devices are two important ways to quantify the severity of motor symptoms for Parkinson′s disease (PD). As one representative of scales, the Unified Parkinson′s Disease Rating Scale is considered the "gold standard" in the comprehensive assessment of PD. External devices are divided into electrophysiological and mechanical devices based on the type of sensors. Both sides can monitor the PD motor symptoms objectively. Currently, numerous and ununified parameters of devices make the clinical quantification of PD symptoms still rely on scales. This article reviewed the progress on quantitative assessments of motor symptoms for Parkinson′s disease.