INTRODUCTION: Kaposi sarcoma (KS) is a multicentric, vasoproliferative tumor. Human herpes virus 8 has been demonstrated to have a direct role in its development. Classic Kaposi sarcoma is seen in HIV-negative, elderly men, often of Jewish or Mediterranean lineage.
CASE REPORT: A 78-year-old, HIV-negative man presented with a 4-year history of multiple nodules and plaques on both lower extremities. Histologic findings were consistent with nodular Kaposi sarcoma. Immunohistochemistry studies showed CD34+ cells. Tumor cells stained positive for HHV-8 latent nuclear antigen. As palliative treatment, the patient underwent external beam radiotherapy.
CONCLUSION: Classic Kaposi sarcoma tends to run an indolent course. Progression of skin lesions however, can lead to immense discomfort and disfigurement. As there is no definitive treatment algorithm for KS, management decisions should be made judiciously to choose the most effective treatment that will cause the least morbidity.

Human ; Male ; Aged ; Antigens, Nuclear ; Disease Progression ; Hiv Infections ; Herpesvirus 8, Human ; Lower Extremity ; Palliative Care ; Sarcoma, Kaposi ; Skin Diseases ; Skin Neoplasms ; Treatment Outcome