1.Restorative therapy using autologous bone marrow derived mononuclear cells infusion intra-arterially in patients with cerebral palsy: An open label feasibility study
MV Padma Srivastava ; A Bhasin ; S Mohanty ; S Sharma ; U Kiran ; CS Bal ; S Gaikwad ; MB Singh ; R Bhatia ; M Tripathi ; K Prasad ; S Singh ; V Goyal ; G Shukla ; M Behari
Neurology Asia 2011;16(3):231-239
Cerebral Palsy is a common and devastating neurological disorder, with no medical treatment apart
from physiotherapy regimes to alleviate the functional disability. Regenerative medicine using stem
cells has gained momentum in recent years as a possible strategy to repair the injured brain. Present
study was undertaken in a open label series to evaluate the safety, feasibility and observe for any
benefi cial effects of intra-arterial infusion of autologous bone marrow derived mononuclear cells in
patients with cerebral palsy with moderate disability. Functional improvement was assessed using
the motor power and spasticity scales, dystonia and abnormal movements scale and the activities of
daily living scales by modifi ed Barthel Index and modifi ed Rankin Scores. Serial structural imaging
with MRI and functional imaging with FDG-PET scans were done. Of the 30 patients injected with
an average of 10-30 million cells into each carotid artery, improvements were observed in all clinical
scales, and predominantly in the disability scores. No adverse events were noted on a 12 months
follow up.
Result Analysis
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