No abstract available.
Chlorpromazine* ; Nicotine* ; Skin*

No abstract available.
Chlorpromazine* ; Hyperpigmentation ; Pigmentation*

To determine if retrobulbar administration of chlorpromazine can alleviate the pain and promote lowering of intraocular pressure in absolute glaucoma, ten patients with painful absolute glaucoma received retrobulbal injection of 1.5 cc each of xylocaine and chlorpromazine. Pre- and post- injection intraocular pressures and pain grading were compared and analyzed statistically using the T test (L=0.01, 99.9%).Signs and symptoms of hypotension were monitored.A 75% reduction of pain was noted one hour post-injection and 95% three months post-injection in 9/10 patients.Intraocular pressure decreased by 30% in 7/10 patients one day post injection.Pressure-lowering effect however was not sustained for three months
Human ; GLAUCOMA ; CHLORPROMAZINE ; XYLOCAINE

No abstract available.
Cataract* ; Chlorpromazine* ; Skin Pigmentation* ; Skin*

Priapism is a well recognized complication of some oral medications. Those most commonly cited are: antipsychotic drugs, especially the phenolhiazine: trazodone and chlorpromazine :and the antihyperlensive drugs hydralazine, guanethidine and prazocin. We report a case or priapism associated with the use of chlorpromazine who experienced 2 episodes or priapism and never experience priapism after cessation of the drug.
Antipsychotic Agents ; Chlorpromazine* ; Guanethidine ; Hydralazine ; Priapism* ; Trazodone

In 54 cases with heterophoria, the effects of the tranquilizers were studied. The minimum doses of two kinds of tranquilizers i.e., phenothiazine derivative (chlorpromazine) and benzodiazepine derivative (oxazepam) were given for 3 days. The results were as follows: 1. In 18 cases (43%) of the 30 cases who complained asthenopia, the symptom was relieved to some extent. The improvement of the symptom occurred with decrease in the Jateral phoria in 13 cases, and with increase in fusional amplitude in 13 cases. 2, There were no changes in the lateral phoria in 31 cases (59%) at distance, but at near, in 27 cases (52%) there was decrease in the lateral phoria. The amount of the increment or decrement in prism diopters was somewhat larger at near than at distance, and also somewhat larger in cases, in which the initial lateral phoria before medication is high, than in the cases with low initial lateral phoria. 3, There were no changes in the fusional amplitude in 24 cases (46%) at distance, but at near, in 28 cases (55 %) there was the increase in fusional amplitude. The changes in the amount of the increment or decrement in the fusional al1}plitude were similar to that of the changes in the amount in lateral phoria. 4, There were no remarkable changes in vertical phorias. 5. In exophoria there were no remarkable differences between subjects given chlorpromazine and those gIven oxazepam.
Asthenopia ; Benzodiazepines ; Chlorpromazine ; Exotropia ; Oxazepam ; Strabismus

The effects of an antipsychotic, chlorpromazine, on the electroencephalogram (EEG) were observed while rats were awake but immobile. The time course and the dose-dependency of the EEG changes were examined. The method of the power spectrum analysis was used to examine the EEG changes by the drug. The bands were divided into delta (1 ~ 3.5 Hz), theta (3.5 ~ 8 Hz), alpha (8 ~ 13 Hz), beta1 (13 ~ 21 Hz), beta2 (21 ~ 30 Hz) and gamma (30 ~ 50 Hz). In rats, the low dose of chlropromazine (1 mg/kg, i.p.) produced a significant increase in the power of the beta1 band. The higher doses (5, 10 mg/kg, i.p.) produced a significant increase in the power of the delta, theta, alpha and beta1 bands, and the decrease in the power of the gamma band. The powers of the bands changed dose-dependently. Then, the authors discussed whether the EEG effects produced by a drug are associated with the accompanying behavioral changes specifically.
Animals ; Chlorpromazine* ; Electroencephalography ; Rats* ; Spectrum Analysis

OBJECT: The aim of this study is to determine whether exposure to chlorpromazine causes mutagenicity and genetic disorders. METHOD: Ames (Salmonella typhimurium) test and Rec assay (Bacillus subtilis) were used as indicators for DNA damage. Furthermore, the levels of umu operon expression by measuring the beta-galactosidase activity were monitered with the SOS umu test using S. typhimurium 1535 containing plasmid pSK1002. And the host-mediated assay was used to investigate the muta-genicity of chlorpromazine after the activation with in vivo metabolic systems. RESULTS: From the results, chlorpromazine did not affect DNA of S. typhimurium and B. subtilis strains and showed no mutagenicity at the all concentrations tested. These phenomena was also similar to that after metabolic activation of chlorpromazine in in vivo system. CONCLUSION: These results suggested that chlorpromazine did not show the mutagenicity and genotoxicity by four different methods used in this study.
beta-Galactosidase ; Biotransformation ; Chlorpromazine* ; DNA ; DNA Damage ; Operon ; Plasmids

BACKGROUND: The main therapeutic method currently used for the treatment of vitiligo vulgaris is either photochemotherapy or corticosteroids. But both of the procedures however require lengthy treatment to obtain a satisfactory result. OBJECTIVE: To determine the increased efficacy of the combination therapy of photochemotherapy with corticosteroid and chlorpromazine compared with the usual monotherapy. METHODS: The combination therapy was done in 29 cases and the results were compared with the results of either monotherapy appearing in the literatures. RESULTS: f the 29 patients, 14(48.3%) patients achieved 100% repigmentation, 7(24.1%) patients 75~50%, 5(17.2%) patients 25~50%, and 3(10.4%) patients less than 25%. For the cured patients, 190.3 days and 32.7 times of photochemotherapy were used. CONCLUSION: The combination therapy is more effective, and the duration of treatment can be greatly reduced compared with either monotherapy.
Adrenal Cortex Hormones ; Chlorpromazine ; Humans ; Methods ; Photochemotherapy ; Vitiligo*

The action of chlorpromazine on Na-K-ATPase activity of rabbit brain homogenate was examined. The results were summarized as the follows: 1. Chlorpromazine inhibited Na-K-ATPase activity in the a dose dependent manner with an estimated I50 of 6s 10(-5)M. 2. Hydrolysis of ATP was linear with time and enzyme concentration with or without cholorpromazine in reaction mixture. 3. Altered pH and activity curves of Na-K-ATPase demonstrated comparable inhibition by chlorpromazine in fuffered acidic, netral and alkaline pH ranges. 4. Kinetic analysis of the effect of chlorpromazine on the various parameters which influence Na-K-ATPase activity revealed that the inhibition was apparently competitive with respect to Na+, and noncompetitive with repect to ATP and K+. Based on these data it is suggested that the inhibition by chlorpromazine is not a consequence of change of affinities of ATP, Mg++ and K+ for the enzyme. Results also indicate that chlorpromazine at the Na+ binding site has an important functional role for the activation of the enzymeby Na+.
Adenosine Triphosphate ; Binding Sites ; Brain* ; Chlorpromazine* ; Hydrogen-Ion Concentration ; Hydrolysis