Both DNA methylation and microRNAs(miRNA)play important roles in the development and progression of human cancer. Recently, it has been demonstrated that the promoter of miRNA can be methylated and DNA methylation can be regulated by miRNA through DNA methyltransferase. Research targeting this reciprocal regulatory mechanism may shed some light on the diagnosis and treatment of cancer.

China ; Humans ; Practice Guidelines as Topic ; Rhinitis, Allergic ; diagnosis ; therapy

Child ; Glucocorticoids ; therapeutic use ; Histamine Antagonists ; therapeutic use ; Humans ; Rhinitis, Allergic, Perennial ; drug therapy

Humans ; Pre-Exposure Prophylaxis ; methods ; Rhinitis, Allergic, Seasonal ; drug therapy ; Seasons

Child ; Desensitization, Immunologic ; Humans ; Rhinitis, Allergic ; Rhinitis, Allergic, Perennial ; therapy

Evidence-Based Medicine ; Humans ; Rhinitis, Allergic, Perennial ; drug therapy ; Rhinitis, Allergic, Seasonal ; drug therapy

Allergy and Immunology ; Ethnic Groups ; Humans ; Hypersensitivity ; immunology

OBJECTIVE:To prepare Lipoic acid orally disintegrating tablets,and to evaluate its quality. METHODS:Lipoic acid orally disintegrating tablets were prepared with direct compression after wet granulation. With disintegration time and dissolu-tion as index,the constituents of disintegrating agent,filler and lubricant were screened by single factor test combined with orthogo-nal test. The tablet weight,hardness,disintegration time,accumulative rate and percentage content were investigated. RESULTS:The optimal formulation was MCC 167.58 mg,L-HPC 23.94 mg,PVPP 47.88 mg,mannitol 60 mg,lipoic acid 300 mg and mag-nesium stearate 0.6 mg. The parameters of prepared disintegrating tablets was as follows as (0.59 ± 0.05) g in weight,(20.32 ± 0.16)kg in solidity and(23.5±0.4)s in disintegration time,101.49% in 3 min accumulative dissolution rate,96.34% of labeled content. CONCLUSIONS:Lipoic acid orally disintegrating tablets are prepared successfully and controllable in quality.

Asthma ; diagnosis ; therapy ; Humans ; Practice Guidelines as Topic ; Rhinitis, Allergic, Perennial ; diagnosis ; therapy