1.Research progress of Manganese-enhanced MRI optic nerve tracing in vivo
Chinese Journal of Experimental Ophthalmology 2016;34(6):562-565
Manganese-enhanced MRI (MEMRI) optic nerve tracing in vivo is a technology which can reflect the axonal transport status and visual pathway connection by utilizing divalent manganese ion's transportability in axons and its characteristics of paramagnetism,and such potential optic nerve tract-tracing technique has been widely used in ophthalmologic research.Mn2+ enters the neurons through the voltage-gating Ca2+ channel and is transported by microtubule system which is not depended on cellular electric activity.However,the trans-synaptic transport of Mn2+ relies on membrane potential.Taking advantages of MEMRI,optic nerve injury-related research could be implemented.Mn2+ is an intracellular contrast agent with metal toxicity,so low dose,fractionated,targeted delivery of Mn2+ is recommended to alleviate the adverse effects of Mn2+.Herein,the mechanism of divalent manganese ion optic nerve tracing,application of MEMRI in ophthalmologic research field,drug delivery approach of divalent Mn2+ and its toxicity were summarized.
2.The function of epigenetic modification in human leukemia
Journal of Leukemia & Lymphoma 2010;19(5):313-316
In the past few years, people have a new understanding of the mechanism of Epigenetic disease. Epigenetic modification processes involved in human disease include DNA methylation, histone acetylation and methylation, RNA-associated silencing.Epigenetic modification related with cell growth, differentiation, apoptosis, transformation and tumor progression-related gene transcription. There has been a long time that the gene mutations involved in tumor formation. In recent years.more and more evidences that genetic and epigenetic modifications leading to the formation of tumors. Epigenetic modifications has also play a very important role in the formation of tumors. This article discussed the DNA methylation.histone post-translational modification anomalies and small interference RNA impact on the formation of leukemia. It provides new prospects for the treatment of leukemia.
3.Correlation analysis of the clinical factors for diabetic retinopathy
International Journal of Laboratory Medicine 2009;30(8):750-751,755
mia and hypertension are the major risk factors for occurrence of diabetic retinopathy.High UA may be also associated with occurrence of diabetic retinopathy.
4.Progress of bacterial cellulose and optimize production in the medical field
International Journal of Biomedical Engineering 2014;37(6):376-379
Bacterial cellulose,as a new material,due to its unique nano-fiber mesh structure with good purity,physical and chemical properties such as mechanical strength and water holding capacity,biocompatibility and adaptability,has been widely used in medicine,food,paper,textile,acoustical materials and other industries.In medical field,especially,it has been rapidly developed in recent years.This review discusses the current bacterial cellulose and its performance optimization products which relates to the medical applications.
5.Clinical observation of the development of juvenile myopia wearing glasses with full correction and under-correction
International Eye Science 2014;(8):1553-1554
AIM:To observe the effect of wearing glasses with full correction or under-correction on the development of juvenile myopia.
METHODS:This study included 132 cases ( 264 eyes ) from January 2008 to September 2012 who were collected from our clinic. They were divided into 2 groups, full correction and under- correction. Students in group 1 wore glasses with full correction, students in group 2 wore glasses with under-correction 0. 25D to 0. 5D lower than normal. Reexamination was done every 6mo. After 12mo, refractions were checked, the development of myopia was compared.
RESULTS: There were no statistically significant differences between two groups after 6mo ( P=0. 0693 );however, there were significant differences after 12mo( P=0. 0013).
CONCLUSION:The development of myopia is slow if students often wear glasses with full correction.
6.A Study of Relativity between TCM Syndrome and Clinic Pathology on 1010 Patients with IgA Nephropathy
Journal of Medical Research 2006;0(08):-
Objective To explore the TCM syndrome of IgAN, and formulate standard scheme on differentiation of symptoms and sings. Methods Adopted epidemiological investigation of TCM syndrome, and analyzed the relativity of clinic and pathology with the TCM syndrome. Results Two schemes of TCM showed that the qiyinliangxu syndrome was primary pattern of IgAN. The TCM syndrome showed changes of single syndrome (qiyinliangxu) → bideminy syndrome (qiyinliangxu accompanied shenluoyubi or fengshineirao)→ trigeminy syndrome (qiyinliangxu accompanied shenluoyubi and fengshineirao) with the aggravation of IgAN.Conclusions The New Scheme was more predominant in differentiation of symptoms and sings than The Old Scheme, and The New Scheme was more easy to operat and master. It was worthy to spread and utilize The New Scheme in clinic.
7.CT Diagnosis of Retroperitoneal Fibrosis (8 cases report)
Journal of Zhejiang Chinese Medical University 2006;0(04):-
[Objective] To evaluate and describe CT findings in patients with pathologically confirmed retroperitoneal fibrosis. [Methods] CT findings in 8 patients (6 males, 2 females) pathologically confirmed retroperitoneal fibrosis were retrospectively reviewed and pertinent literature was discussed. [Results] Retroperitoneal fibrosis showed similar features in CT imaging: retroperitoneal irregular mass around abdominal aorta embedding adjacent tissue, with mild or moderate enhancement, unilateral or bibateral ureterectasis with hydronephrosis. [Conclusions] The pristine clinical manifestation of retroperitoneal fibrosis is occult and nonspecific. CT examination is a valuable approach to diagnose retroperitoneal fibrosis.
8.Clinic Observation of Tiepi Fengdou Granule as Adjuvant Treatment in Cancer Patients During Chemotherapy
Journal of Zhejiang Chinese Medical University 2006;0(04):-
[Objective] To evaluate the effect of Tiepi Fengdou Granule(TFG) as adjuvant treatment in cancer patients during chemotherapy.[Methods] Twenty patients were treated with TFG,and then we added up integral calculus of Yin Deficiency symptoms,tested blood routine,hepatic and renal function and subgroup of T-cell and NK cell.[Results] The Yin Deficiency symptoms of 7 cases(35%) were improved significantly,and 13 cases were partly improved(65%).Each integral calculus of Yin Deficiency symptoms was descended.The tested blood routine,hepatic function and subgroup of T-cell and NK cell were changed significantly.[Conclusions] TFG could control the symptoms of Yin Deficiency and improve immune function for cancer chemotherapy patients.
9.Discussion on the development of nanjing general hospital of nanjing military command based on the SWOT analysis
Journal of Medical Postgraduates 2003;0(03):-
SWOT method was used to analyze the internal strengths,weaknesses,external opportunities and threats of Nanjing General Hospital of Nanjing Military Command,PLA. Based on the results,four development policy were put forward:developing the sections prepared for war; inducing invigorative system in human resource management; enhancing the value of nosocomial brand; strengthening of the audit about the medical cost accounting.
10.Effect of Tetramethyl Pyrazine on Infarct Areas and Expressions of ED1,IL-1?,TNF-? after Focal Cerebral Ischemia Reperfusion in Rats
Chinese Journal of Information on Traditional Chinese Medicine 2006;0(05):-
Objective To investigate the effect of Tetramethyl Pyrazine(TMP) for treating cerebral infarct by observing infarct areas,and to research its function mechanism by observing the changes of the expressions of ED1,TNF-? and IL-1? in the infarction region after focal cerebral ischemia reperfusion injury.Methods Sixty SD male rats in healthy condition were randomly and averagely divided into normal group,model group and TMP high,middle and low dose group.The cerebral infarct animal model was reproduced by modified thread-tie method.TMP high dose group was administered TMP 140 mg/kg,middle dose group was 120 mg/kg and low dose group was 100 mg/kg by intravenous.Then all the rats were killed.Thirty rats were taken to evaluate whether TMP can decrease the ratio of cerebral infarction areas in the TTC-reacting and formalin fixation brain tissue slices taken from the above-mentioned killed rats,with Pathology Image Analysis System.The masculine of ED1,IL-1? and TNF-? in the immuno-reacting cells in cerebral infarction brain tissue slice taken from other thirty killed rats were observed.Results TMP groups decreased the ratio of cerebral infarction areas,and also decreased ED1,TNF-? and IL-1? in immuno-reacting cell.Conclusion TMP can decrease the formation of cerebral infarction caused by cerebral ischemia reperfusion and its effect is possibly related to the activation of microglia,as well as the immuno-positive expressions of TNF-? and IL-1?.