Vav3 oncogene is a member of the Vav family. Vav3 protein contains multiple functional motifs and is involved in cancer development and progression through its role in various cellular signaling processes, including cytoskeleton organization, calcium influx, genetic transcription, cell transformation, proliferation and apoptosis. In addition, Vav3 interacts with estrogen receptor and enhances ERα-mediated signaling axis, therefore plays an important role in breast cancer.

Coronary Artery Bypass ; methods ; utilization ; Coronary Artery Disease ; pathology ; surgery ; Graft Survival

Adult ; Automobile Driving ; Female ; Hip Fractures ; etiology ; Humans ; Male ; Middle Aged ; Occupational Injuries ; complications ; Retrospective Studies ; Young Adult

Objective To analyze the clinical behavior and correlative mechanism of the patients with the syndrome of neck injury associate with craniocerebral injury,to investigate its incidence for contributing to the diagnosis and therapy of the patients with the craniocerebral injury and improving the postoperative result. Methods Two hundred and eighty-three patients with craniocerebral injury treated from June 2000 to July 2003 were studied retrospectively. Results In 283 patients, 42( 14.8%) patients presented the syndrome of neck injury clearly in symptom or sign, of whom 39 ( 13.7% ) patients were diagnosed neck injury finally, 3 (1.1%) patients were clinically conclude neck injury. The syndrome mainly presents with noncerebral and nonaural vertigo incorresponding with the recovery of brain injury. Noncerebral, nonaural and nondigestive vomit. Intractable nuchal rigidity incorresponding with the recovery of brain injury. Motion and position limited, stubborn neck malaise, transient spinal cord injury. The symptoms were easy to be improved by neck motion control, neck traction,block therapy, massage and physiotherapy lamp. Conclusion The syndrome of brain-neck injury is a common injury. To learn the syndrome and take the regular therapy can improve the therapeutic efficacy of the craniocerebral injury.

Objective:To analyze CT characteristics of pancreatic carcinoma coexisting with chronic pancreatitis versus chronic pancreatitis in order to improve its CT differential diagnostic accuracy.Methods:CT findings in 14 cases of pancreatic carcinoma coexisting with chronic pancreatitis and 15 cases of chronic pancreatitis were retrospectively analyzed.Both plain and enhanced CT scans were performed in all cases.Thin-layer scan was practiced when required.Observation was focused on the size,shape,density of pancreas,its relationship with Peripancreatic tissues,the images of enhancement,and the location,size,density of pancreatic carcinoma.Moreover,observation was focused on the dilation of common bile duct,main pancreatic duct and hepatic bile duct Then,CT characteristics of pancreatic carcinoma coexisting with chronic pancreatitis and chronic pancreatitis were analyzed and compared.Results:In the pancreatic carcinoma coexisting with chronic pancreatitis group,all cases have mass,and noenhancement in the arterial phrase.Peripancreatic blood vessels were invaded or surrounded(5 cases and 4 cases respectively).Peripancreatic adipose were not seen enough(5 cases).Lymph node enlargement(4 cases),Liver metastasis(5 cases).Dilation of common bile duc(t8 cases,9.67 mm?2.64 mm),6 of which showed broke off abruptly.Pancreas atrophy(6 cases),Calcification(4 cases),Dilation of main pancreatic duc(t7 cases),Pseudocys(t2 cases).In chronic pancreatitis group,pancreatic mass(2 cases),one of which showed no enhancement in the arterial phrase;Peripancreatic blood vessels was surrounded by Peripancreatic mass and the boundary between blood vessels and adipose was not clear(1 case);None of the cases was seen Peripancreatic blood vessels invasion;no liver metastasis or Lymph node metastasis.Dilation of common bile duc(t3 cases,7.53 mm?1.45 mm),one of which showed broke off abruptly.Pancreas atrophy(7 cases),Calcification(5 cases),Dilation of main pancreatic duct(7 cases,4.73 mm?3.04 mm),Pseudocyst(4 cases).Conclusion:Style of mass dynamic enhancement of pancreatic carcinoma coexisting with chronic pancreatitis,Peripancreatic blood vessels invasion,liver metastasis,and lymph node metastasis are important basis of CT differentiation of pancreatic carcinoma coexisting with chronic pancreatitis from chronic pancreatitis.

Composition of invention patent application is important for obtaining patent right and maintaining the right stability. According to the features of TCM invention patent application and common problems in examination, this article summarized several key points for effective application composition, including composing background technology objectively, highlighting technical problems, reasonable layout of technical pian, working in contact with technical effects, and clarifying technical terms. It expounded each point with relevant typical cases, with a purpose to provide references for applicants and agents of TCM invention patent application.

Objective To study the effect of different draining way in the surgical treatment of chronic subdural haematoma (CSDH). Methods 126 patients with CSDH diagnosed by CT scanning or MRI were enrolled. The burr-hole was made at the site of the maximal hematoma thickness. A drainage tube was placed towards either the occipital (group A) or frontal ( group B) region as far as possible respectively, and for the latter, a lateral aperture was made about 2 cm far from the burr-hole on the side of the tube. The surgical complication (such as pneumocephalus, brain injury and recurrent hematoma et al.) and therapeutic efficacy of the two treatments were compared and analyzed to evaluate an optimal surgical technique. Results After treatment, complication rate in group A is 30%, the occurrence of complications in group B rate is 2% (P <0.05); operation time and hospitalization time in group B was significantly shorter than that in group A (P <0.05). Conclusion In the surgical treatment of CSDH, improved drainage pathway is safe and effective, which could improve the treatment efficacy and is worthy of clinical promotion.

Objective To develop an informatized continuous education system for theater nurse based on PDCA theory.Methods The system was gifted with the functions of learning planning, learning execution, learning checking, data management and system management based on PDCA theory, informatized technology and other learning systems.Results The system behaved well in overall flow and configuration, man-machine interaction and application, which facilitated the nurses to learn with fragmented time.Conclusion The nursing continuous education is enhanced greatly with the system.

OBJECTIVE: To investigate the growth inhibition and apoptosis of BGC-823 gastric cancer cells induced by Oridonin and its mechanism. METHODS: The Oridonin-treated BGC-823 cells were detected using MTT, transmission electron microscopy (TEM), TUNEL and flow cytometry (FCM) etc. RESULTS: Oridonin(16, 32, and 64 ?g?mL-1) significantly inhibited the proliferation of BGC-823 cells in dose and time dependent manner, with the inhibition rates at 68.5%, 90.8%, and 94.7%, respectively within 24, 48, and 72 h after treatment with 64 ?g?mL-1 Oridnin. When treated with 32 ?g?mL-1 Oridonin for 2 h,mitochondria and endoplasmic reticulum were proliferated and swelled under TEM; At 8 h,vacuolization of mitochondria and endoplasmic reticulum were noted, the internal structure disappeared, and the nuclear chromatin margination vacuolization were in typical apoptosis change; At 24 h, BGC-823 cells were arrested at G2/M phase, and the apoptosis rate was 37.8% under FCM. CONCLUSION: Oridonin inhibiting proliferation and apoptosis of BGC-823 cells maybe related to G2/M phase arresting, and Oridonin induce apoptosis of BGC-823 cells may through mitochondria or endoplasmic reticulum apoptosis pathway.

Lipoprotein lipase (LPL) is the rate-limiting enzyme for the hydrolysis of the triglyceride core of circulating triglyceride-rich lipoproteins.LPL can not only affect the lipoprotein level,but also play an important role in the development of atherosclerosis.LPL gene polymorphisms may affect LPL activity,and therefore have both pro-and anti-atherogenic effects.This article reviews the relationship between LPL gene polymorphism and atherosclerosis.