Objective To investigate the correlation of fasting plasma glucose (FPG) in early period of pregnancy and abnormal glucose metabolism during gestation period.Methods Two hundred and seventy-seven women with single pregnancy and non-propregnant diabetes mellitus were selected.FPG,fasting insulin,insulin resistance index were detected in early period of pregnancy ( ＜19 weeks).One hundred g oral glucose tolerant test (OGTT) was taken during 24-36 weeks.According to OGTT,patients were divided into gestational impaired glucose tolerance (GIGT) group (24 cases),gestational diabetes mellitus(GDM) group(23 cases),OGTT 1 h higher blood glucose (HG-1) group (26 cases) and normal group (204 cases).Results FPG,fasting insulin and insulin resistance index of GDM group and HG-1 group were obviously higher than those of normal group [( 4.58 ± 0.36 ),( 4.58 ± 0.38) mmol/L vs.( 4.20 ±0.33) mmol/L,(9.4 ± 1.1),(9.3 ±2.1) U/L vs.(7.0 ± 2.1) U/L,2.0 ± 0.4,2.0 ± 0.3 vs.1.3 ± 0.4,P＜ 0.05].FPG of GIGT group [(4.45 ±0.36) mmol/L] was higher than that of normal group (P ＜0.05).After controlled age,body mass index,family history of type-2 diabetes mellitus and sport exercises,the relative risk degree of blood glucose metabolism had correlation with FPG,fasting insulin and insulin resistance index in early period of pregnancy (P ＜ 0.05).Conclusion FPG,fasting insulin and insulin resistance index in early period of pregnancy can predict abnormal glucose metabolism.

BACKGROUND:About 50% patients with coronary heart disease have no symptoms of cardiac disease before the first onset of myocardial infarction. Therefore, it is of great importance to make early and accurate detection of coronary heart disease and myocardial ischemia.OBJECTIVE: To measure the time of heart repolarization with magnetocardiography and probe into the role of non-invasive magnetocardiographic examination in evaluating cardiac function in patients with coronary heart disease.DESIGN: Case-control observation.SETTING: Department of Cardiology of Philippustift Hospital, Essen,GermanyPARTICIPANTS: Totally 52 patients hospitalized for suspected coronary heart disease in the Department of Cardiology of Philippustift Hospital(Essen, Germany) between March 1998 and December 2002 were recruited,and another 10 patients diagnosed as old myocardial infarction were set as myocardial infarction group. Informed consents were obtained from the patients. Totally 32 healthy volunteers aged above 40 years old were recruited as the control group.METHODS: All the patients received the following examinations: physical and laboratory examinations, rest and stress electrocardiography(ECG), echocardiography, coronary artery angiography and magnetocardiography(MCG) examination. The control group received only rest ECG and MCG examination. The values of QT dispersion with ECG and MCG were compared between the patients and healthy controls. The diagnostic criteria for coronary heart disease: stenosis of one coronary artery ≥ 75% according to coronary artery angiography; index of repolarization time of the heart was measured with MCG QT dispersion and MCG dispersion coincidence (the mean of probe signal and QT dispersion of peripheral probe in each MCG).MAIN OUTCOME MEASURES: ECG QT dispersion, MCG QT dispersion as well as coincidence index of QT dispersion of the observed subjects in each group.RESULTS: The 52 patients with suspected coronary heart disease,10 with myocardial infarction, and 32 healthy controls all entered the result analysis. The patients with suspected coronary disease were divided into 2 groups: group with coronary heart disease (n=27) and group without coronary heart disease (n=25). [1] Comparison of ECG QT dispersion: there was no significant difference among the groups(P ＞ 0.05). [2] Comparison of MCG QT dispersion: MCG QT dispersion in myocardial infarction group was significantly higher than that in control group [81.3±21.5, 52.4±13.6 (F=13.113, P ＜ 0.05)]. [3]Comparison of coincidence index of QT dispersion: Coincidence index of QT dispersion in myocardial infarction group and coronary heart disease group was both significantly higher than that in control group [15.6±4.2, 14.9±4.1, 10.2±2.7 (F=2.403, 3.332, P ＜ 0.01)].CONCLUSION: Compared with ECG, MCG can better reflect changes in the repolarization process of patients with coronary heart disease,and coincidence index of dispersion is superior to QT dispersion. This is because MCG is more sensitive to tangential currents presented at the precardial region when myocardial ischemia and infarction occur.

Objective To study the relationship between the change of resting electrocardiogram ST-T in chronic stable coronary atherosclerotic heart disease(CAD) and left ventricle enjection fraction(LVEF).To know the significance that the change of ST-T may predict the function of left ventricle.Methods 80 patients with CAD in our c ardaic department were analyzed retrospectively,40 patients with the change of ST-T (positive group) and 40 patients without the change of ST-T(negative group) were analyzed the outcome of LVEF and the extent of coronary lesion.Results The LVEF of positive group was lower than negative group obviously,the comparision between both groups had statistical significance (t =6.125,P =0.000).In the electrocardiogram positive group,the number of the patients who had 2 and more than 2 branches lesion was more than negative group,the comparision between both groups had statistical significance(x2 =9.683,P =0.008).Conclusion The change of ST-T may predict the function of left ventricle of patients with chronic stable coronary atherosclerotic heart disease,the relationship may be connected with the degree of coronary lesion.

OBJECTIVE To discuss about the recurrent respiratory tract infections(RRTI) treatment by traditional Chinese medicine.RRTI is very commonly in children. METHODS According to clinical experience, as well as integrated with Western medicine,we think about the mechanism of RRTI from two sides.The main reason was the function of lung and spleen deficiency in traditional Chinese medicine theories;another reason was attached with outside evils.We treaed RRTI with different syndromes with different methods,such as dispelling the evil in the superficies with acrid drugs and cod drugs,regulating the function of lung and spleen;supplement Qi and supporting superficies, regulating Ying and Wei,nourishing Yin to reduce heat,strengthening the spleen and nourishing lung. RESULTS It has a good theropentio effective with traditional Chinese medicine on RRTI.During acute infectious period,we treated mainly eliminate evils,as well as to support healthy energy.During recovery period,we treated mainly support healthy energy,as well as to eliminate evils. CONCLUSIONS Traditional Chinese medicine has long time therapentir effect on RRTI,with less recurrence.

Objective To optimize the extraction technology of Morchella polysaccharide.Methods With GIM5.69(Morchella esculenta(L.) Pers.) and GIM5.29(Morchella elata) as the research object,the difference of polysaccharide yield with lixiviation in polysaccharide extraction between ultrasound and enzyme was observed.At the same time,the difference of polysaccharides yield of these two Morchella was compared.Result Ultrasound and enzyme both can improve the polysaccharides yield,and the effect of 10 min of ultrasound was the best.The polysaccharides yield of GIM5.69 was higher than that of GIM5.29,which means different strain has different polysaccharides yield.Conclusion The best extraction condition is 10 min of ultrasound at the frequency of 40 kHz,heating 150 min at 90 ℃ and lixiviation twice.

Objective:To evaluate the quality condition and problems of acetylspiramycin at present. Methods:According to the standard described in Chinese Pharmacopoeia (2015 edition), acetylspiramycin and its preparations were determined, and the overall quality level of domestic acetylspiramycin was evaluated. The related substances, components and dissolution were analyzed to further explore the quality status. Results:In 258 batches of samples, the dissolution of only one batch did not meet the standard with the passing rate of 99. 6%. The results of exploratory research showed that the content of impurities in raw material was determined by the synthesis process, and the impurity profile of domestic and foreign formula was different. The dissolution behavior of domestic and for-eign formula in four kinds of media was not similar as well. Conclusion: The quality of domestic acetylspiramycin is promising. The research of related substances provides the reference for controlling the target impurities. The consistency assessment of dissolution pro-vides the reference for the formula process improvement and clinical application of acetylspiramycin tablets.

OBJECTIVE:To discuss the trend of hospital preparations in the future METHODS:The developing history of and the main factors influencing hospital preparations were analyzed by literature review RESULTS & CONCLUSION:The trend of hospital preparations depends on the role and task of the hospital pharmacy The development of hospital preparations may have three possibilities:being repealed;being reduced;and being maintained the current situation It is not optimistic for the future of hospital preparations from the view of hospital pharmacy

To observe the effect of "Yixintang" on the protection of the myocardium against ischemia reperfusion injury. Thirty Wistar rats, with their hearts isolated, were randomly divided into three groups: Yixintang group 1 (YXT1, with 0 01g "Yixintang" in each ml K H fluid), Yixintang group 2 (YXT2, with 0 1g "Yixintang" in each ml K H fluid) and control group. Left ventricular systolic output pressure (LVSP), rate of rise of left ventricular pressure (?dp/dt max ), left ventricular end diastolic pressure (LVEDP), heart rate, the content of malondialdehyde(MDA) in myocardial tissue were measured. The results showed that cardiac functions seemed to recover well after ischemia reperfusion injury in the group 2. The values of myocardial dynamics and hemodynamics indexes, including LVSP and ?dp/dt max , in the group 2 were obviously higher than those in the control group after ischemia reperfusion. The content of MDA in myocardial tissue was obviously lower in the group 2 than in the control group after ischemia and reperfusion. There was significant difference between Yixintang group 2 and control group ( P

Objective To investigate neuro-biochemical changes of bilateral anterior cingulate cortex (ACC) in the patients with major depressive disorder (MDD) and the correlation between abnormal metabolism and the cognitive function before and after treatment.Methods Fifteen patients with major depression and 15age-,sex-and education-matched healthy controls (HC) were involved.The neurochemical abnormalities including the levels of N-acetylaspartate (NAA),choline-containing compounds,glutamate/glutamine and myoinostol were measured by single-voxel proton magnetic resonance spectroscopic (1H-MRS).The subjects were then assessed with executive function with neuropsychological tests including Wisconsin cards sorting test (WCST),verbal fluency Task (vF),StrooP Color and Word Test (SCWT).After this,the patients took selectivity serotonin reuptake inhibitors (SSRIs) for eight weeks.Then,we examined the changes in NAA,Cho,Glx and MI in ACC of patients and assessed their executive function with the neuropsychological tests again.Results 1) In ACC,baseline NAA ((7.36 ± 1.67) mmol/L),GLx ((11.68 ± 1.65) mmol/L) and MI levels ((5.28 ± 0.66) mmol/L) were significantly lower in MDD compared to those of HC (NAA (9.27 ± 1.37)mmol/L,Glx (15.20 ± 1.91)mmol/L,MI (7.80 ± 2.73) mmol/L) (P ＜0.01) ; After treatment,the NAA ((9.34 ± 2.45) mmol/L) and Glx ((16.79 ±3.96) mmol/L) increased significantly after treatment compared to those prior to pretreatment (NAA(7.36 ± 1.67)mmol/L,Glx(11.68±1.65)mmol/L,P＜0.05).2) The normal controls exhibited better in Performance of WCST and Performance of completion time of SCWT than our MDD patients (P＜0.05 or P＜0.01).The patients made significant improvements in Performance of WCST and completion time of SCWT(C form) after treatment (P＜0.05 or P＜0.01).3) In post-treatment MDD,the ACC Glx level was significantly positively correlated with the categories completes of WCST (r=0.739,P=0.009) and inversely related with the numbers to complete the first categories of WCST (r=-0.699,P=0.017) and the completion time of SCWT(C form) (r=-0.651,P=0.030) ;elevated MI(r=-0.705,P=0.023) and NAA(r=-0.735,P=0.010) levels in ACC of post-treatment MDD were both negatively correlated with the numbers to complete the first categories of WCST.Conclusion The ACC may be a key region involved in antidepressant treatment in MDD.The increased ACC NAA,Glx and MI in MDD after treatment may be significantly correlated with the improve of executive function.

In recent years, the incidence of the allergic skin diseases is increasing as the growing of the pressure, the changes of the environment and other factors. The clinical features of the allergic skin diseases are easily repeated and in long course. It is found that the incidence of clinical allergic skin diseases, in addition to the season, diet and emotional relevant, is also closely linked to the physical deterioration of patients. Therefore, in addition to the emphasis on the treatment of the current symptoms of patients, adjustment and treatment of phsical constitution of patients and improvement of the adaptability of patients to environmental changes should attract attention, thereby reducing the frequency of incidence and alleviating the symptoms. The application of the abdominal acupuncture combined with body acupuncture for the improvement of the symptoms and physical constitution of allergic skin disease patients has obvious efficacy, which should be applied and promoted in clinic.