The treatments for ankylosing spondylitis (AS) are still not effective, which partially due to its unclear patho?genesis. Interleukin (IL)-23/IL-17 axis is a significant immunologic pathway which has attracted much attention in the past few years. This article reviewed the role of IL-23/IL-17 axis in genetic and immunological pathogenesis of AS, and intro?duced the recent progresses in treatments of AS using anti-IL-23 or anti-IL-17 antibody. The important role of IL-23/IL-17 axis in the pathogenesis and treatment of AS indicates its potential use as a new therapeutic target.

ObjectiveTo investigate the risk factors of early postoperative complications after pancreaticoduodenectomy.MethodsThe clinical data of 159 patients undergoing pancreaticoduodenectomy from March 2005 to October 2010 was analyzed retrospectively.The related factors of early postoperative complications were analyzed.ResultsThe incidence rate of early postoperative complications was 30.8％ (49/159).Univariate analysis showed that preoperative fasting blood glucose level,total serum bilirubin level,serum albumin level,high density lipoproteins level and intraoperative bleeding were closely correlated with early postoperative complications in patients undergoing pancreaticoduodenectomy (P ＜ 0.05),but gender,age,preoperative jaundice,history of diabetes mellitus,operation time and whether portal vein reconstruction were no significantly associated with early postoperative complications in patients undergoing pancreaticoduodenectomy (P ＞ 0.05).Multivariate analysis showed that preoperative fasting blood glucose level( ≥6.1 mmol/L),total serum bilirubin level ( ≥ 171 μ mol/L) and serum albumin level( ＜ 35 g/L) were the important independent risk factors of early postoperative complications in patients undergoing pancreaticoduodenectomy.ConclusionThe risk factors of pancreaticoduodenectomy should be fully recognized and dealt with promptly.

Objective To investigate the efficacy of flupentixol and melitracen(Deanxit) in treatment of non-erosive reflux disease(NERD) and non-responding to proton pump inhibitor. Methods Fifty eight NERD pa-tients were randomly divided into two groups, the treatment group (n = 29) and control group (n = 29). Patients in control group were given esomeprazole 40 mg qd. Patients in the treatment group were given the same drug plus Deanxit 1 Tab qd. The clinical effect was evaluated and scored by Hemihon Anxiety Rating Scale (HAMA) after 4 weeks. Results The total efficacy rate of the treatment group was higher than control group (P < 0.01),and HAMA was lower in the treatment group than in control group (P < 0.01). Conclusions Adjuvant treatment of Deanxit combined with esomeprazole is effective to NERD patients who did not respond to proton pump inhibitor, can greatly improve anxious disorders.

Objective To study the mechanism of male infertility. Methods Forty sperms from 8 normal males as control and 60 sperms from 12 males with infertility were observed by SEM.The ultrastructure of acrosomes was analyzed and compared. Results Spermatozoa with obscure ringed rips in infertile group acounted for 66.7%(40/60),serrate 65.0%(39/60);but in control group,the proportions were 10.0 % (4/40) and 5.0%(2/40),respectively.The ratios of acrosome to head in infertile group were ( 70.0 ?8.0)%,greater than controls (57.7?6.4)%.The ratios of acrosome membrane which was not intact were 70.0%(42/60) in infertile group and 22.5%(9/40) in control group.Acrosomes with rough surface were 68.3%(41/60) and 20.0%(8/40) respectively in the 2 groups;Acrosomes with particles adhesive to the surface were 65.0%(39/60) and 27.5%(11/40) respectively. Conclusions Abnormal acrosome structure is one of the causes of male infertility.

Objective To explore a practicable method of serial sections of whole CNS in the rat, in which both neurons and nerve fibers were showed at the same section. Methods After perfused fixation and quick freezing, the tissues of whole CNS were cut into serial sections with cryostat followed by hematoxylin stain. Results The nerve fibers were stained in blue color while the neurons were showed black-blue and the background was light-yellow.Conclusion Our method was feasible to show both neurons and nerve fibers at the same section with quick freezing, freezing serial sectioning and improved hematoxylin staining.

Objective To investigate the correlation of nuclear factor‐κB (NF‐κB) with metabolic syndrome(MS). Methods A total of 240 subjects living in rural areas of Ningxia were enrolled in this study and divided into two groups :MS group (n= 120 ) and healthy control group (n= 120 ). The relationship of NF‐κB with MS was evaluated by t‐test ,partial correlation and conditional logistic regression analysis. Results Whole blood NF‐κB protein level was significantly lower in MS group than in control group [(352.31 ± 307.35) vs (441.00 ± 345.10) ng/L ,P<0.05]. Whole blood NF‐κB protein level was significantly lower in male ,Han nationality ,and 45~55 years old patients of MS group than in control group (P<0.05). Partial correlation analysis showed that NF‐κB was associated with BMI (β=-0.146 ,P=0.025) .Conditional logistic regression analysis showed that whole blood NF‐κB protein was a protective factor for MS (OR=0.91 ,95% CI:0.72~0.98 ,P<0.05). Conclusion The blood NF‐κB level is associated with MS.

Objective To observe the clinical efficacy of acupuncture, chiropractic plus functional exercise of lumbar and gluteal muscles in treating postpartum sacroiliac malposition.Method Forty patients with postpartum sacroiliac malposition were randomized into group A, group B, group C and group D, 10 cases in each group. Group A was intervened by acupuncture, chiropractic plus functional exercise of lumbar and gluteal muscles, group B by acupuncture plus chiropractic, group C by acupuncture plus functional exercise of lumbar and gluteal muscles, and group D by chiropractic plus functional exercise of lumbar and gluteal muscles. The four groups were intervened once every other day. The modified Oswestry Disability Index (ODI) score was observed before and after 5 treatment sessions, and the clinical efficacies in the four groups were compared.Result The total effective rates were 100.0% in the four groups, and the inter-group differences were statistically insignificant (P>0.05). The ODI scores in the four groups were significantly changed after treatment and in the 3-month follow-up study compared with those before the treatment (P<0.05). After the treatment, the ODI score in group B was significantly different from that in the other groups (P<0.05). The ODI scores in group A and B in the 3-month follow-up study were significantly different from those after the treatment in the same group (P<0.05). The ODI score in group A was significantly different from that in the other groups in the 3-month follow-up study (P<0.05). The ODI score in group B in the 3-month follow-up study was significantly different from that in group C and D (P<0.05).Conclusion Acupuncture, chiropractic plus functional exercise of lumbar and gluteal muscles is definitely effective in treating postpartum sacroiliac malposition, acupuncture plus chiropractic can produce a significant short-term efficacy and alleviate the symptoms, and functional exercise of lumbar and gluteal muscle can produce an obvious long-term efficacy.

Objective To study the iatrogenic risk factors of post-ERCP pancreatitis (PEP).Method A meta-analysis was carried out on 15 clinical studies which included more than 100 patients published in the medical literature in the last twenty years.Result When the risk factors were analysed,OR for endoscopic sphincterotomy (EST) was 3.75 (95％CI 3.01-4.68),OR for papillae precut was 2.17 (95％CI 1.76-2.67),OR for biliary sphincter balloon dilation was 1.66 (95％CI 1.16-2.39),OR for pancreatic contrast injection was 2.79 (2.31-3.37),OR for sphincter of Oddi manome try was 5.86 (95％CI 5.04-6.80),OR for pancreatic stenting was 2.57 (95％CI 2.09-3.17).Conclusion The analysis indicated EST,papillae precut,balloon dilation,pancreatic contrast injection,Oddi manometry,non-prophylactic pancreatic duct stenting were the risk factors of post-ERCP pancreatitis.

Objective To investigate the clinical effects of Shenlong decoction(main ingredients consisted of ginsent root,radix polygonimultiflori,Pheretima,Ligusticum wallichii,Fructas Alpiniae oryphyllee etc.)on the treatment of cerebral vascular dementia (VD)in the elderly patients.Methods VD in all the patients(age:72.1?5.3 years old)was diagnosed according to the APA criteria, and the cerebrovascular diseases were confirmed by CT or MRI.68 patients were divided into 2 groups randomly.The experimental group consisting of 36 patients was given Chinese traditional medicine,Shenlong decoction,orally 500ml q.i.d.for 3 months,and the other 32 patients were given acetamide pyrrolidone(piracetam)orally 1.6g,tid for 3 months as a control group.The MMSE(Mini Mental State Examination)and BBS(Bless Behaviour Schedule)were used to evaluate the cognitive function and the daily activity in those patients be- fore and after treatment.Results After treatment,the scores of cognition and daily activity were improved in all the patients with VD. The effective rate in the Shenlong group was 52.8%,and 53.13% in the piracetam group.There was no significant difference in the im- provement of the short time memory and orientation ability between the two groups.However,compared with the control group,the score of daily activity was significantly improved in the Shenlong decoction group only(P

The endothelial cells activated by tumor cells are genetically stable and regress easily. Moreover, at the surface there are specific markers, which are easily accessible by system administration. This report review the studies of tumor treatment targeting at the activated endothelial cells.