Objective To investigate the clinical efficacy of triple method of heat-sensitive point moibustion and Taiji acupuncture plus massotherapy in treating facial spasm.Method Sixty patients with facial spasm were randomly allocated to treatment and control groups, 30 cases each. The treatment group received triple method of heat-sensitive point moibustion and Taiji acupuncture plus massotherapy and the control group, conventional acupuncture plus suspended moxibustion with moxa stick. After three courses of treatment, the clinical therapeutic effects on spasm (severity and frequency) were compared between the two groups. Result The total efficacy rate and the cure and marked efficacy rate for spasm (severity) were 86.7% and 43.3%, respectively, in the treatment group and 66.7% and 26.7%, respectively, in the control group; there were statistically significant differences between the two groups (P<0.01). The total efficacy rate and the cure and marked efficacy rate for spasm (frequency) were 83.3% and 46.7%, respectively, in the treatment group and 66.7% and 30.3%, respectively, in the control group; there were statistically significant differences between the two groups (P<0.01).Conclusion Triple method of heat-sensitive point moibustion and Taiji acupuncture plus massotherapy is an effective way to treat facial spasm.

Objective To observe the effect of transcutaneous electrical stimulationon on Jiaji acupoint (Ex-B 05) on the expression of glial fibrillary acidic protein (GFAP), nuclear factor kappa B (NF-κB) and interleukin-6 (IL-6) in rats with spinal cord injury (SCI). Meth-ods Ninety healthy adult Sprague-Dawley rats were randomly divided into normal group (group A, n=30), transcutaneous electrical stimula-tion treatment group (group B, n=30) and control group (group C, n=30). Allen's method was used to establish the model of acute SCI in T9. All of them were assessed with Basso-Beattie-Bresnahan (BBB) scale and Slanting Board Test, and the expression of GFAP, NF-κB and IL-6 of the spinal cord were detected with immunohistochemistry one, three and seven days after operation. Results The results of BBB scale and Slanting Board Test were better in group B than in group C three and seven days after SCI (t>3.349, P<0.01). The expression of GFAP, NF-κB and IL-6 was lower in group B than in group C at all the time points after SCI (t>20.815, P<0.001). Conclusion Transcutane-ous electrical stimulation can inhibit the inflammation and the expression of GFAP in spinal cord after SCI, and improve the motor function in rats after SCI.

Objective To observe the effect of proanthocyanidin on the expression of brain- derived neurotrophic factor (GFAP) and brain-derived neurotrophic factor (BDNF) in rats with spinal cord injury (SCI). Methods 48 healthy adult Sprague-Dawley rats were randomly divided into proanthocyanidin treatment group (group A, n=24) and control group (group B, n=24). Allen's method was used to establish the model of acute spinal cord injury in T9. 1, 3 and 7 days after operation, 8 rats in each subgroup were assessed with Basso-Beattie- Bresnahan (BBB) scale and Slanting Board Test, the serum malondialdehyde (MDA) and superoxide dismutase (SOD) were detected, and the expression of GFAP and BDNF of the spinal cord were detected with immunohistochemistry. Results The results of BBB scale and Slanting Board Test were better in group A than in group B 3 and 7 days after SCI (P<0.05). The levels of SOD and MDA were better in group A than in group B 1, 3 and 7 days after SCI (P<0.05). The expression of GFAP was lower, and the expression of BDNF was higher in group A than in group B all the time points after SCI (P<0.01). Conclusion Proanthocyanidin can inhibit the lipid peroxidation and the expression of GFAP in spinal cord after SCI, stimulate the synthesis of endogenous BDNF, and improve the motor function in rats after SCI.

0.05).Conclusions In vivo ischemia models,the suitable dose GM can reduce the expression of iNOS,inhibit the cell apoptosis and protect the nerve cell.

Objective To investigate the risk factors of contrast-induced renal nephropathy(CIN)in patients with coronary disease treated with interventional therapy and summarize the nursing strategies. Methods One hundred and twenly CHD patients treated with PCI were selected.Logistic regression analysis was done to screen out the risk factors of CIN. Result The main risk factors included renal inadequacy,advanced age,diabetes and contrast dosage(all P<0.05). Conclusion Risk assessment before PCI,rational use of contrast and preventive nursing measures are essential for the prevention and reduction of CIN.

OBJECTIVE:To establish a rapid method for the concentration determination of lamotrigine (LTG) in human se-rum. METHODS:HPLC was adopted after serum samples treated with methanol. The column was Hypersil BDS C18(200 mm×4.6 mm,5μm)with the mobile phase of methanol-KH2PO4(45∶55,V/V)at the flow rate of 1 ml/min,the detection wavelength was 250 nm,and the temperature was 35℃. RESULTS:The linear range of LTG was 0.5-30.0 μg/ml(r=0.999 9). The RSDs of intra-day and inter-day were all less than 5% and the recovery was 101.96%-102.74%. CONCLUSIONS:The method is simple,accurate and fast,and suitable for the monitoring of LTG serum concentration.

Objective To investigate correlation between cystatin C (Cys C) and target organ damage (TOD) in elderly hypertension and its clinical significance.Methods One hundred patients with TOD in elderly hypertension were selected as an observation group.One hundred patients without TOD in elderly hypertension were recruited as the controll group.And sixty healthy aged persons were recruited as healthy group.Serum concentration of Cys C in all cases was measured by the particle enhanced nephelometric immunoassay.At the same time,serum creatinine (Scr),urine albumin (mALB) and left ventricle mass index (LVMI) via ultrasonography were also detected.Correlation of Cys C with the above measurements were analyzed.Results The Cys C concentration was significantly higher in observation group [(1.84±0.32) mg/L] than in contrast [(0.92±0.36) mg/L] and healtbygroups [(0.85±0.34) mg/L],F=88.43,P=0.000.However,the difference in level of Cys C was not statistically significantly different between controll group and healthy group (P ＞0.05).In observation group,serum concentration of Cys C was positively correlated with Scr,mALBand LVMI (r=0.420,0.526,0.470,P=0.021,0.019,0.034) after adjusting age.Conclusions Serum level of Cys C is markedly elevated and is positively correlated with Scr,mALB and LVMI in patients with TOD in elderly hypertension.It can be considered as one of the useful factors for evaluating TOD in elderly hypertension.

Breast cancer is a systemic disease, only through multidisciplinary treatment including surgery, radiotherapy, chemotherapy, endocrine, can we enhance its effectiveness. In recent years, neoadjuvant chemotherapy for breast cancer has aroused great interest in tumor academia. We hope that this therapy can not only improve breast conservation rate, but also extend the overall survival through a series of clinical studies. This review presents the research progress of neoadjuvant chemotherapy for breast cancer.

Objective To introduce the method, indications and the usage of abdominal double layer subcutaneous flap for the repair of late complicated hand injury. Methods A new type of flap was designed to repair the complicated hand injury. Sixteen cases were treated with this method since 1998. Results The duration of the follow up ranged from 3 to 24 months with an average of 13 months. All of the flaps survived well. After physiotherapy, the overall excellent and good rate of joint movement was 80%(TAM standard). No further surgery was required in all of the cases. Conclusion The abdominal double layer subcutaneous flap was especially indicated in those cases with bone nonunion, tendon and nerve defect and tendonous adhesions. This kind of flap not only provide a good skin covering, but also offer a soft bed for the tendons, nerves, and bones.

Objective To study the appropriate antibiotic for prophylactic use in cesarean section. Methods The effects and side effects of prophylatic antibiotics in 1 266 cesarean section were studied retrospectively. Six regiems were engaged: (1) Penicillin and Ampicillin; (2) Mezlocillin sodium; (3) Sulbactam and Ampicillin; (4) Ciprofloxacin; (5) Clindamycin; (6) Cefacidal. Results The duration of postoperative body temperature return to normal of 1-6 group is (54.0?28.4) hours, (48.9?27.8) hours, (49.9?23.9) hours, (58.6?33.7) hours, (52.5?25.2) hours, (63.1?51.1) hours respectively. It was longer in cefazolin group than the others. There were less puerperal morbidity and side effects of Mezlocillin. Conclusions Penicillin and Ampicillin are still the most common choices as prophylatic antibiotic in cesarean section. Mezlocillin is appropriate as well.