Anti-N-methyl-D-aspartate receptor encephalitis is an autoimmune syndrome of central nervous system.The main clinical manifestations include psychiatric symptoms,movement disorders and seizures.It is often misdiagnosed as viral encephalitis.Tumors,especially the ovarian teratoma,play an important role in the disease.The prevalence in children is beyond imagination.Anti-NMDAR antibodies are specific diagnostic tests.Immune suppression is the main treatment.The first-line treatments include corticosteroids,intravenous immunoglobulin,and plasmapheresis.The second-line treatments include biological agents and cytotoxic drugs.Early diagnosis and treatment are essential for neurologic recovery.Overall prognosis is good.

Objective To investigate the effect of Tongxinluo capsule combined with metoprolol on elderly patients with coronary heart disease and angina pectoris and its influence on hemorheology and inflammatory factors.Methods 135 elderly patients with angina pectoris of coronary heart disease were selected,and they were randomly divided into treatment group (68 cases) and control group (67 cases).The treatment group was treated with Tongxinluo capsule combined with metoprolol,while the control group was treated with metoprolol.The two groups were treated for 8 weeks.The curative effect of the two groups was compared,the number and duration of angina pectoris,the changes of hemorheology and inflammatory factors before and after treatment were compared.Results The total effective rate of the treatment group (94.12％) was higher than 76.12％ of the control group (P ＜ 0.05).After treatment,the frequency and duration of angina pectoris in the treatment group were (6.03 ± 1.21) times/week and (3.02 ± 0.76) min/time,respectively,which were significantly lower than those in the control group [(9.87 ± 1.46) times/week and (4.86 ± 0.98) min/time] (t =16.649,12.201,all P ＜ 0.05).After treatment,the whole blood viscosity at high shear rate [(3.76 ± 0.41) mPa/s],whole blood viscosity in low shear [(8.13 ± 0.76) mPa/s],plasma viscosity [(1.23 ± 0.08) mPa/s],erythrocyte aggregation index [(2.06 ± 0.27)],fibrinogen [(2.46 ± 0.41) g/L] in the treatment group were lower than those in the control group[(4.53 ± 0.52) mPa/s,(9.61 ± 0.89) mPa/s,(2.09 ± 0.27) mPa/s,(2.63 ± 0.35),(3.53 ± 0.62) g/L] (t =9.562,10.396,25.170,10.604,11.844,all P ＜ 0.05).After treatment,the interleukin-6 (IL-6) [(8.49 ± 1.76) pg/mL],intercellular adhesion molecule-1 (ICAM-1)[(85.25 ± 8.92) pg/mL],C reactive protein (CRP) [(8.74 ± 1.76) mg/L] in the treatment group were lower than those in the control group[IL-6 (11.32 ± 2.10) pg/mL,ICAM-1 (103.42 ± 10.72) pg/mL,CRP (14.98 ± 2.24)mg/L] (t =8.491,10.712,18.012,all P＜0.05).Conclusion Tongxinluo capsule combined with metoprolol in the treatment of elderly patients with coronary heart disease angina pectoris has obvious curative effect,and can improve the patients'blood rheology and inflammatory reaction.

ObjectiveTo investigate the relationship between carotid atherosclerosis and progressing stroke.Methods103 patients with acute cerebral infarction within the first 24 hours from onset were tested with carotid color doppler ultrasonography during the first week from admission. Univariate and multiple logistic regression analyses were performed to examine the relationship between carotid intima media thickness (IMT), plaque structure, the degree of artery stenosis and the early deterioration of cerebral infarction.ResultsPrevalence of carotid plaque and thickness of IMT in patients with progressing stroke were higher than that in non progressing patients. In logistic regression, presence of carotid plaque was independent predictors of progressing stroke. Plaque size, extent of artery stenosis and IMT were not included in the regression model.ConclusionPlaque structure and its chemical feature may be the cause of progressing stroke.

As the most popular simplified model of the optical imaging system, the acquisition of the Gaussian point spread function (PSF) parameter is one of the hotspots and key points on which people do research in the field of image restoration. Based on the idea by which there exists deterministic mathematical relationship between Gaussian OTF feature points as well as its parameter and the frequency representation of the image in an existed literature, we proposed an automatic, accurate, stable, and improved approach. This method is able to give prominence to the related calculation feature by a Gaussian convolution and degeneration operation and finally realize the automatic esti mation of PSF parameter of a microscopic image. Experiments have proved that a good restoration result can be achieved utilizing the estimated PSF by the present method, which is of considerable application and reference value in restoration of other sorts with Gaussian approximate PSF model or 3D microscopic image restoration.
Algorithms ; Humans ; Image Interpretation, Computer-Assisted ; Imaging, Three-Dimensional ; Microscopy ; Models, Theoretical ; Normal Distribution

Coronal restoration of endodontically treated teeth may be viewed as one of the main parameters that influence the outcome of endodontic treatment. The purposes of restoring endodontically-treated teeth include preventing recontamination of the root canal system and periapical area, replacing the compromised dental hard tissue, restoring the coronal morphology and function, providing necessary strength for the restoration/tooth complex for functional stress, and avoiding crown and/or root fracture. This article reviewed recent researches on the restoration of endodontically treated teeth, provided evidence for clinical practice on topics as when to restore them, basic principles to be considered during treatment planning, and specific restoration options for both anterior and posterior teeth under different functional occulsal load conditions. Several issues should be taken into account during the decision making process, such as remaining tooth tissue, functional masticatory forces, comprehensive oral rehabilitation, and esthetic requirements.
Decision Making ; Dental Restoration, Permanent ; Humans ; Root Canal Therapy ; Tooth Crown ; Tooth, Nonvital

The dissolution rates of Yiganling Tablets produced by 6 pharmaceutical factories of China and Liganlong Tablets by MAOAUS Factory in German were investigated. As a result, after 30min, the dissolution of all Yiganling is below 30％ and that of Liganlong is 50%. After 120min, the largest dissolution of the former isn't over 43%, and that of the later is about 55％, which indicates that silymarin tablets dissolve more slowly and their bioavailability is lower. The dissolubility can be raised 37, 60 and 27 times, respectively if the silymarin was made into PEG fusion) PVP coprecipitation or ?-CD inclusion compound. The disolution rate (T_(50)) of correspording tablets are 14, 11 and 20min. The largest dissolution after 120min reaches about 80%-103％. There isn't any change observed in the structure of silymarin in solid dispersion when it was identified with UV, IR and TLC. The micropolariscope photograph shows the crystal degree decreased and the dispersity increased.

The weevil, Dyscerus sp. is an extinctive pest of officinal magnolia. lt causes heavy Iosses of Magnolia officinalis in producing area such as Longquan city,Jingning and Songyang county of Zhejiang Province. The present paper report for the first time,its harmful effect and method of its prevention and control.

The thermogravimetric analysis was developed for the identification of powders and extracts of Radix Ginseng and Radix Panacis Quinquefolii. This method is simple,quick and accurate with small sample. It is avaliable for the identification of true and false product series of Radix Ginseng and Radix Panacis Quinquefolii in current market.

Objective To explore the role of Bc1\|2,Bc1\|x1 and Bax during the process of Ginsenoside Rg1 protecting against apoptosis of substantia nigra neurons in Parkinson disease(PD) mouse model. Methods C57BL mice were administrated i.p. with MPTP to produce PD mouse model.And different doses of Rg1(2 5,5 0,10 0?mg/kg) were given i.p. prior 3 days to MPTP in preventive groups.Nissl staining,tyrosine hydroxythase(TH) immunostaining and TUNEL staining were used to observe the changes of nigra neurons.Bc1\|2,Bc1\|x1 and Bax immunostaining were used to detect the expression of these proteins. Results Pretreatment with Rg1(5 0,10 0?mg/kg) could prevent the loss of Nissl staining neurons and TH\|positive neurons,and decrease TUNEL\|staining ratio.Rg1 could enhance the expression level of Bc1\|2 and Bc1\|x1,and reduce the expression level of Bax. Conclusion\ Rg1 has protective effect on apoptosis of substantia nigra neurons in PD mouse model.The increased expression level of Bc1\|2 and Bc1\|x1,and the decreased expression level of Bax may be the important mechanism during Rg1 protection against apoptosis.