No abstract available.
CA-125 Antigen* ; Humans ; Ovarian Neoplasms*

No abstract available.
CA-125 Antigen* ; Female ; Pregnancy ; Pregnancy, Ectopic*

Pleural effusion is a common diagnostic problem. The analysis of serum and pleural fluid for tumour markers is widely used as a diagnostic aid in clinical practice. The aim of the present study was to determine the usefulness of simultaneous quantification of carcinoembryonic antigen (CEA) and carbohydrate antigen (CA-125) in distinction of malignant from benign effusion. Data from a total of 78 patients including 53 patients with benign and 25 patients with malignant effusion was evaluated. The cut-off values for differentiating benign from malignant effusions were determined using results obtained from patients with known benign effusions (mean + 2 SD, 95% confidence interval). The cut-off for CEA and CA-125 were 5.1 ng/ml and 1707 IU/ml respectively. CEA assay in pleural fluid had an acceptable sensitivity and good specificity of 64% and 98% respectively. CA-125 had a sensitivity of 36% and specificity of 94%. The combination of the two tumour markers gave a sensitivity of 72% and specificity of 92.4%. We suggest a good clinical strategy may be to begin with CEA measurement (assay specificity 98%); if CEA is below the cut-off value (negative), CA-125 could then be measured to improve the sensitivity of detection of malignant effusions. However, measurement of these tumour markers is not cost effective from the point of view that it does not give information on the type of malignancy present. The latter has to be determined either by histological or cytological study.
CA-125 Antigen ; Carcinoembryonic Antigen ; Malignant Neoplasms ; Benign ; Pleural Effusion

OBJECTIVE: The tumor antigen CA 125 is known to be elevated in the some endometrial carcinoma patients. In several reports, the serum levels of CA 125 seem to be increased in the majority of patients with advanced disease, but only in about 10-20% of patients with stage I disease. In other reports, no such correlation between CA 125 levels and extent of disease has been observed. The purpose of this study was to evaluate relevance of CA 125 level and stage of endometrial cancer. METHODS: This is a clinical study of 46 cases of endometrial cancer evaluated at Chun-an Soonchunhyang University Hospital during Jan. 1997 to Jan. 2004. The age of patients distributed from 36 to 76 years old. The concentration of serum CA 125 tumor marker was determined for all patients who were prepared for surgery. Patients of stage I, II was 26 cases and stage III, IV was 20 cases. For the statistical analysis, we employed the Mann-Whitney U test (p<0.05). RESULTS: 22 patients of stage I, 4 of stage II, 12 of stage III and 8 of stage IV were confirmed by postoperative pathohistologic analysis. The CA 125 level of stage I, II group and stage III, IV group were checked from 6.2 U/mL to 562 U/mL. In stage I, II group, mean value of CA 125 was 44.52+/-17.02. In the other group, mean value of CA 125 was 128.91+/-53.15. p-value of T-test was not significant (p:0.06>0.05). But, by Mann-Whitney U test, mean ranking of stage I, II group was 9.38 and stage III, IV group 15.40. p-value of Mann-Whitney U test is statistically significant (p:0.04<0.05). CONCLUSION: Determination of tumor markers appears to be important in endometrial cancer patients. Concentrations of serum CA 125 in patient sera may indicate the level of malignant potential and thus help in choosing an appropriate therapeutic procedure.
Aged ; CA-125 Antigen ; Endometrial Neoplasms* ; Female ; Humans ; Biomarkers, Tumor

100 patients had undergone for ovarian tumor at Tu Du Obstetrics and Gynecology Hospital from the year 2002 to 2004, in which 19 cases with malignant tumors and granulosa cell tumors, there were 81 benign cases. CA 125 was a biological test to predict the maglinancy and benign of granulosa cell tumors that had rather high predictation, mostly in cases of eliminating from ovarian tumor. CA 125 in serum at the theresholds of 35 UI/ml and 60 UI/ml gave the best result with the sensitivity and the specificity of 80%. CA 125 could use as systematic test before operation of the ovarian tumor pathology that applied in hospitals having surgical treatment this disease, the price of this test was not higher than CT scanning
Ovarian Neoplasms ; Neoplasms ; CA-125 Antigen ; Predictive Value of Tests

Pseudo-Meigs' syndrome (PMS) is a rare disease characterized by the triad of (1) an ovarian neoplasm, other than a fibroma or thecoma, (2) ascites, and (3) pleural effusion. Tumors such as struma ovarii, mucinous and serous cystadenomas, and germ cell tumors have been linked with the condition. Due to its clinical features combined with the elevation of serum cancer antigen 125 (CA-125) levels, it is often mistaken and treated as a malignant ovarian tumor. Ascites or pleural effusion could be massive leading to various life-threatening complications. Despite its presentation, this entity has an excellent prognosis when surgical excision of the tumor is performed. This article presents an unusual case of a 41-year-old gravida 10 para 10 (10-0-0-9) who was diagnosed with a case of struma ovarii associated PMS with concomitant abdominopelvic tuberculosis and elevated CA-125 resembling an ovarian malignancy.
Ascites ; Struma Ovarii ; Meigs Syndrome ; CA-125 Antigen ; Abdominal Neoplasms

Isolated torsion of the fallopian tube in postmenopausal women is rare. In this case report, we detail the case of a 53-year-old patient who presented with adenomyosis and a left hydrosalpinx with high levels of CA 125 and CA 19-9. The isolated torsion of the left hydrosalpinx was observed during the operation. The serum levels of CA 125 and CA 19-9 were reduced from 129.62 and 348 to 58.2 and 12.41 U/mL, respectively, after total laparoscopic hysterectomy with salpingectomy. On radiologic evaluation, there were no other factors that may have influenced the increase in serum levels of CA 125 and CA 19-9 in this patient, which were reduced after operation. To the best of our knowledge, this is the first case of association between perioperative changes in CA 19-9 levels and isolated torsion of the fallopian tube.
Adenomyosis ; CA-125 Antigen ; CA-19-9 Antigen ; Fallopian Tubes ; Female ; Humans ; Hysterectomy ; Middle Aged ; Salpingectomy

OBJECTIVEThis study was aimed to evaluate the significance of bone marrow(BM) morphological examination and many tumor marker(TM) detection, especially carcinoembryonic antigen (CEA), cancer antigen 125(CA125), cancer antigen 15-3 (CA15-3) and serum ferritin (SF) for lymphoma diagnosis and prognosis.

METHODSA total of 47 confirmed patients with lymphoma in our hospital from January 2012 to October 2013 and 20 health peoplels as normal controls were performed with bone marrow morphological examination, at the same time, the electrochemistry luminescent technique was applied for detecting levels of TM (especially CEA, CA125, CA15-3 and SF) in serum samples of lymphoma patient and normal controls, then the BM immature lymphocyte counts of these people and clinical parameters were analyzed for diagnosis and prognosis.

RESULTSThere was significant differences in all the four TM levels between serum samples of lymphoma patients and normal control (P=0.029, P=0.000, P=0.005, P=0.000). These TM levels had no correlation with age, sex white blood cell, lymphocyte, platelet counts and anemia of lymphoma patients (P>0.05). It was also found that the patients with elevated TM levels had high BM immature lymphocytes (lymphoma cells) counts, B symptoms, advanced clinical stage and high IPI index (P<0.05). The CA15-3 and SF levels in serum samples of lymphoma patients with BM infiltration were higher than that in lymphoma patients without BM infiltration (P=0.002, P=0.000).

CONCLUSIONCombination of BM morphological examination with serum TM level detection plays an important role in diagnosis, clinical stage and prognosis evaluation of lymphoma patients. It is also very important for assessing BM infiltration status of lymphoma patients.

Biomarkers, Tumor ; Bone Marrow ; Bone Marrow Examination ; CA-125 Antigen ; Carcinoembryonic Antigen ; Humans ; Lymphoma ; Prognosis

OBJECTIVE: There are limited data regarding the significance of elevated serum CA-125 level during IUI cycles, even though it is used widely during the initial evaluation of infertile patients. The aim of this study was to investigate the prognostic value of serum CA-125 levels during IUI cycles. METHODS: Among the patients with controlled ovarian stimulation and IUI cycles at Seoul National University Hospital from Jan 2005 through Dec 2009, 92 cases with no identified endometriotic lesion, ovarian tumor, salpingeal lesion, or uterine myoma were selected. To compare the clinical characteristics between the pregnancy group and the non-pregnancy group, the Mann-Whitney U test and Fisher's exact test were used. RESULTS: The overall pregnancy rate was 18.5% (17/92). The pregnancy group showed a higher number of follicles 16 mm in diameter (p=0.036), endometrial thickness (p<0.001), ampules of gonadotropin (p=0.009), and higher body mass index (p=0.022) than the non-pregnancy group. No significant difference was observed in the serum CA-125 level or the proportion of patients with CA-125 exceeding 17 IU/mL between the two groups. CONCLUSION: The prognostic value of serum CA-125 level among infertile patients with IUI cycles is considered limited.
Body Mass Index ; CA-125 Antigen ; Gonadotropins ; Humans ; Insemination ; Myoma ; Ovulation Induction ; Pregnancy ; Pregnancy Rate

BACKGROUNDCurrently, all the diagnostic indicators for endometriosis lack perfect sensitivity and specificity. According to the characteristic of endometriosis, we analyzed the new biomarker neutrophil-to-lymphocyte ratio (NLR) and the combination of NLR and serum CA-125 to investigate their diagnostic value for identifying stages III and IV endometriosis.

METHODSThe values of serum CA-125 and routine blood tests were collected from 197 patients with endometriosis, 102 with benign tumors and 112 healthy individuals. We investigated the sensitivity and specificity of NLR and its combination with serum-CA-125 for diagnosing stages III and IV endometriosis by using receiver operating characteristic (ROC).

RESULTSThe mean values of NLR, the combination of serum CA-125 and NLR (combination) of the groups with stages III and IV endometriosis were significantly higher than the other two groups. Serum CA-125, NLR, and the combined biomarkers could significantly discriminate the stages III and IV endometriosis group from the other two groups (P < 0.05). NLR shows a lower sensitivity of 57.9% and specificity of 65.2% with a cutoff value at 1.82. And the combination of biomarkers has the highest AUC of 0.949 with a sensitivity of 86.8% and specificity of 92.0% at the cutoff value of 44.40. In addition, for patients with negative CA-125, 55.36% and 53.57% of the patients were able to be diagnosed with endometriosis by using NLR alone and the combination of biomarkers.

CONCLUSIONFor diagnosing stages III and IV endometriosis, the neutrophil-to-lymphocyte ratio is a better adjuvant to serum CA-125, and the neutrophil-to-lymphocyte ratio is valuable in diagnosing stages III and IV endometriosis for patients with negative serum CA-125.

Adult ; Biomarkers ; blood ; CA-125 Antigen ; blood ; Endometriosis ; blood ; diagnosis ; Female ; Humans ; Lymphocytes ; Neutrophils ; Retrospective Studies