The clinicopathological study was performed on 80 patients with urinary bladder tumor between 1973 and 1983. The histopathological survey was carried out using preserved tumor specimen slide on the retrospective fashion, that included the growth pattern and vessel invasion. The results were as follows : 1. The tumor histology were papillary and nonpapillary in 70 %, and 30 %, respectively in growth pattern and 74 transitional cell carcinoma(TCC), 3 squamous cell carcinoma(SCC), 2 adenocarcinoma (AC) and 1 mucoepithermoid carcinoma in cell type. 2. The Fade of TCC, Go, G1. G2 and G3 were 1.4%, 36.5%, 39.2% and 22.9% respectively, and the stage of those, in which superficial tumors(pTis-pT1) and invasive tumors( pT2-pT4) were 57.0% and 30.8% respectively. The histopathological mode of local spread was to have strands, nests and individual cells in about one sixth, lymphatic invasion in about one third and venous invasion in about one fifth. 3. The intramural hispathological mode of local spread (INF alpha,beta, and alpha), lymphatic invasion ( lyo, 1 and 2) and venous invasion were highly significant with respect to the hispathological grade and stage, and also within mutual relationship on the other hand.
Adenocarcinoma ; Hand ; Humans ; Retrospective Studies ; Urinary Bladder Neoplasms ; Urinary Bladder*

To determine the concentration and the physiologic role of metal components in blood plasma and seminal plasma in relation to male infertility, the concentrations of twelve metal components in blood plasma and seminal plasma including Na, Mg, K, Ca, Cr, Mn, Fe, Cu, Zn, Se, Cd and Pb were measured by atomic absorbance spectrophotometery or ion selective electrode analysis. Semen and blood samples were obtained from a total of 110 men including 70 male infertility patients, 20 vasectomized persons and 20 fertility proven volunteers visited to the Male Infertility Clinic of Pusan National University Hospital. The concentrations of Ca, Zn, Mg, Cr and Cd in control group were higher in seminal plasma than in blood plasma, and additionally Pb were higher in infertility group. The concentrations of all metal components revealed no significant difference according to patients' age, resident, occupation, sperm density, motility and hormone level in blood plasma, but some metal components including Ca, Mg, Cu, Mn, Cd and Pb revealed a significant difference according to each these parameters except patient's age in seminal plasma. The concentrations of Mn, Cd and Pb in the vasectomy persons were higher than in the infertility group III including testicular and epididymal factors, but not in blood plasma. We conclude that the quantitative changes of metal components in the seminal plasma may have effects on not only spermatogenesis and sperm function, but also contribute to diagnostic parameter according to organ specificity of the metal in the male reproduction.
Busan ; Electrodes ; Fertility ; Humans ; Infertility ; Infertility, Male ; Male* ; Occupations ; Organ Specificity ; Plasma ; Reproduction ; Semen* ; Spermatogenesis ; Spermatozoa ; Vasectomy ; Volunteers

Female pseudohermaphrodities are 46XX genetic females with normal Mullerian derivatives, but have various degrees of ambiguous external genitalia. While most of them are commonly associated with adrenogenital syndrome, some of them have been occasionally associated with maternal ingestion of testosterone or synthetic progestational agent, maternal virilizing tumor or rarely idiopathic. Herein, we present three cases of female pseudohermaphroditism which is unrelated with adrenogenital syndrome. One case is resulted from maternal ingestion of progestational agent during the first trimester of pregnancy, and the other idiopathic.
46, XX Disorders of Sex Development* ; Adrenogenital Syndrome ; Eating ; Female* ; Genitalia ; Humans ; Pregnancy ; Pregnancy Trimester, First ; Testosterone

PURPOSE: We evaluated the importance of redistribution and 24 hour reinjection images in Tl-201 SPECT assessment of myocardial viability after acute myocardial infarction (AMI). MATERIALS AND METHODS: We performed dipyridamole stress-4 hour redistribution-24 hour reinjection Tl-201 SPECT in 43 patients with recent AMI (4-16 days). The myocardium was divided into 16 segments and perfusion grade was measured visually with 4 point score from 0 to 3 (absent uptake to normal uptake). A perfusion defect with stress score 2 was considered moderate. A defect was considered severe if the stress score was 0 or l (absent uptake or severe perfusion decrease). Moderate defect on stress image were considered viable and segments with severe defect were considered viable if they showed improvement of 1 score or more on redistribution or reinjection images. We compared the results of viability assess-ment in stress-redistribution and stress-reinjection images. RESULTS: On visual analysis, 344 of 688 segments (50%) had abnormal perfusion. Fifty two (15%) had moderate perfusion defects and 292 (85%) had severe perfusion defects on stress image. Of 292 severe stress defects, 53 were irreversible on redistribution and reversible on reinjection images, and 15 were reversible on redistribution and irreversible on reinjection images. Two hundred twenty four of 292 segments (76.7%) showed concordant results on stress-redistribution and stress-reinjection images. Therefore 24 hour reinjection image changed viability status from necrotic to viable in 53 segments of 292 severe stress defect (18%). However, myocardial viability was underestimated in only 5% (15/292) of severe defects by 24 hour reinjection. CONCLUSION: The 24 hour reinjection imaging is useful in the assessment of rnyocardial viability. It is more sensitive than 4 hour redistribution imaging. However, both redistribution and reinjection images are needed since they complement each other.
Complement System Proteins ; Dipyridamole ; Humans ; Myocardial Infarction* ; Myocardium ; Perfusion ; Tomography, Emission-Computed, Single-Photon

No abstract available.
Parathyroid Neoplasms*

As a part of ongoing effort to evaluate alternative treatments for benign prostatic hyperplasia (BPH}. we compared the outcomes of transurethral resection of prostate(TURP) with those of open prostatectomy(OP). To identify effect of TURP on high mortality due to cardiac death. We compared long-term mortality and the causes of death after each surgical procedures. From Jan 1981 to Dec. 1990, surgical management was underwent on 338 patients with BPH in Pusan National University Hospital. Of 338 patients. survival was identified in 70 of OP group and 166 of TURP group. Direct interview was possible in 50 of OP group and 135 of TURP group. Mean age and follow-up were 69.8 years old and 89.5 months in OP group and 68.7 years old and 45.4 months in TURP group. Both OP and TURP were effective in improving subjective voiding symptoms including comprehensive symptom and Boyarsky symptom score, but, no significant difference was observed between them. Postoperative convalescence period was significantly shorter in TURP group compared to OP group. The incidence of sexual dysfunction including loss of libido and poor erection was similar between two surgical groups, but the incidence of retrograde ejaculation was higher in TURP group than OP group. Postoperative mortality and leading causes of death were no difference between two groups. Conclusively, we could not find the significant differences between OP group and TURP group as to symptom improvement, long-term mortality and morbidity, and effectiveness on patient`s consent. Although we confess that further evaluation is needed for precise and objective results, such results show postoperative improvement of voiding symptoms, quality of life and long-term outcomes that may not depend on surgical options.
Busan ; Cause of Death ; Convalescence ; Death ; Ejaculation ; Follow-Up Studies* ; Humans ; Incidence ; Libido ; Male ; Mortality ; Prostatic Hyperplasia* ; Quality of Life* ; Transurethral Resection of Prostate

Testicular biopsy to have been utilized as a diagnostic tool in male infertility were underwent experimentally to observe the effects on the morphology and the physiology of post-biopsied testis of 17 male rabbits. Bilateral orchiectomy was done at third day, 1st week, 2nd week and 4th week after open testicular biopsy, and biopsied testes were compared with contralateral control in histopathological views. The results were summarized as follows : 1. In seminiferous tubules of sham-operated tests, there was no significant pathologic changes. 2. The inflammatory reaction was most severe at third day after biopsy and completely disappeared at 4th week. 3. Increased thickness of tunica albuginea and fibrotic reaction were observed near the biopsy site. 4. Spermatogenesis did not only decrease near the biopsy site with atrophy of the seminiferous tubules but also mildly decreased on the far area, that all began to recover at 4th week. 5. No evidence of immunologic reaction and hyperplasia of Leydig cell were demonstrated. It was suggested that testicular injury after biopsy was developed by interference of local blood flow, obstruction of seminiferous tubules and inflammatory reaction, so that could be minimized by application of open testicular biopsy only to definitively indicated cases.
Atrophy ; Biopsy* ; Humans ; Hyperplasia ; Infertility, Male ; Male ; Orchiectomy ; Physiology ; Rabbits ; Seminiferous Tubules ; Spermatogenesis ; Testis*

Retroperitoneal teratoma are comparatively rare and yet difficult to treat and predict the prognosis. A case of primary retroperitoneal teratoma in a 28-year-old woman is presented, which was suspected by excretory urography, ultrasonography and angiography, and then preoperatively diagnosed by computerized tomography.
Adult ; Angiography ; Female ; Humans ; Prognosis ; Teratoma* ; Ultrasonography ; Urography

To investigate tumor heterogeneity and the relationship between DNA ploidy and histopathological parameters. flow cytometric assessments were performed on fifteen control bladders and 77 transitional cell carcinomas of bladder confirmed histopathologically. Between August 1984 and July 1990 in Pusan National University Hospital. 31 TUR surgeries and 46 total cystectomies were done and are included in this series. The cystectomized specimens were topographically evaluated with bladder mapping method ; 146 multiple formalin-fixed paraffin-embedded blocks (1-6 blocks with s mean of 3.0) were selected from the histologically different sites including main exophytic mass. concomitant carcinoma in situ. and neighboring normal bladder epithelium. Thirty one TUR blocks (one per case) with histopathological reviews were selected. The results were as follows 1. Flow cytometry positive rates revealed 58.1% in the TUR group and 76.1% in the cystecbmy group 2. Flow cytometry positive rates according to histopathological stage revealed 43.8% and 73.3% of Ta and T1. respectively, in the TUR group, so that in T1 the positive rate is nearly twice that of Ta. Flow cytometry positive rates revealed 100.0%, 70.0%. 100.0%, 66.6% and 77.8% of Tis. T1. T2. T3 and T4, respectively. in the cystectomy group, so that no significant differences were observed between each T-category.3. Flow cytometry positive rates according to histopathological grade revealed 38.5%, 70.6% and 100.0% or grade I, II and III in the TUR group. and O%, 68.0% and 90.0% in the cystectomy group. respectively. So positive rates proportionally increased with up-grading in both TUR end cystectomy groups. 4. Intratumoral ploidy heterogeneity of main exophytic mass in the cystectomy group was in 58.3%, and intertumoral ploidy heterogeneity between main exophytic mass and concomitant carcinoma in situ was 51.7%. 5. DNA ploidy assessment of nontumorous mucosa was thought to provide valuable information for the comprehension of natural history in bladder cancer. 6. DNA ploidy had a significant relationship with the recurrence rates in the TUR group, but was not correlated with the survival rates in contrast to grade and stage in the cystectomy group.According to the above results, we thought that flow cytometric DNA assessment was valuable in evaluating the multicentricity in origin with heterogeneity and to predict the malignant potential as an adjunct of the histopathological factors in bladder cancer.
Busan ; Carcinoma in Situ ; Carcinoma, Transitional Cell ; Comprehension ; Cystectomy ; DNA* ; Epithelium ; Flow Cytometry ; Mucous Membrane ; Natural History ; Ploidies ; Population Characteristics ; Recurrence ; Survival Rate ; Urinary Bladder Neoplasms* ; Urinary Bladder*

Successful removal of staghorn and multiple renal calculi has been one of the mist difficult tasks that confront the urologists. The operative method for removal of the renal calculi was selected according to the size, number, location and anatomic features of the renal collecting system. We utilized the coagulum to improve the success of the stone removal for last five months. The coagulum material were mixed in a ratio of 5ml cryoprecipitate or 4% fibrinogen: 1ml 20 unit /ml human thrombin:0.2ml 10% calcium chloride. The results were as follows. 1. The patients were provided by 3 coagulum pyelolithotomy and 6 coagulum nephrolithotomy, of which utilized cryoprecipitate in 7 cases and 4% fibrinogen in 2 for the fibrinogen source. 2. The seven of nine cases(78.2%) were successfully removed without residual stone, but incompletely in two cases(22.2%). 3. Nondemonstrable stone of the preliminary film were removed additionally in one cases(11.1%). 4. As to the complication, meaningless wound infection and dehiscence was observed in only one case. On basis of our experiences, present here a histologic perspectives, methods, cases and its results, in dication and contraindication for coagulum pyelolithotomy and nephrolithotomy.
Calcium Chloride ; Fibrinogen ; Humans ; Kidney Calculi ; Wound Infection