1.Correlation of the International Index of Erectile Function and Penile Vascular Status in Patients with Erectile Dysfunciton.
Byung Gi OH ; Hana YOON ; Woo Sik CHUNG
Korean Journal of Urology 2000;41(11):1379-1383
No abstract available.
Humans
2.A Urodynamic Database Management using MS Access Computer Program.
Kap Byung KIM ; Dong Woo RO ; Duk Yoon KIM
Journal of the Korean Continence Society 1999;3(1):35-40
No abstract available.
Urodynamics*
3.Bilateral Wilms Tumor: A Case Report.
Gyung Woo JUNG ; Jin Han YOON ; Jong Byung YOON
Korean Journal of Urology 1987;28(3):419-422
A male child of 9 months with bilateral Wilms tumor was admitted to our hospital. His chief complaint was abdominal mass. Clinical examination and IVP, USG and CT-scan disclosed bilateral Wilms tumor. Right nephrectomy and left partial nephrectomy were performed. Anuria was experienced to 24 hours and so exploratory-laparotomy was done. Renal autotranplantation was performed because of the thrombosis of renal artery. But six days after operation he died.
Anuria
;
Child
;
Humans
;
Male
;
Nephrectomy
;
Renal Artery
;
Thrombosis
;
Wilms Tumor*
4.Studies on the Association between Phenylpropanolamine (PPA) and Hemorrhagic Stroke in Other Countries.
Seung Mi LEE ; Byung Woo YOON ; Byung Joo PARK
Korean Journal of Epidemiology 2004;26(2):1-7
OBJECTIVES: Phenylpropanolamine (PPA) had been used widely as cold remedies or appetite suppressants. However, products containing PPA were withdrawn in sequence in the US, Japan, and Korea due to the increased risk of hemorrhagic stroke. The purpose of this paper was to review safety issues related with the PPA use and hemorrhagic stroke in view of pharmacoepidemiology and pharmacovigilance. METHODS AND MATERIALS: Researches conducted for evaluating the association between the PPA use and hemorrhagic stroke in other countries were reviewed, which involved case reports, case series, case-control studies, and cohort studies. RESULTS: In terms of pharmacologic and clinical features, PPA may increase the risk of hemorrhagic stroke through increased blood pressure, heart rate, or vasculitis. The association between the PPA use and hemorrhagic stroke among young women was suggested by case reports from spontaneous adverse events reporting systems or medical journals. The cohort study, using the large prescription database in the US and published in 1984, failed to reveal the association in the population aged below 65. The case-control study conducted as the Yale Hemorrhagic Stroke Project, published in 2000, was the first study to find the association between the PPA as appetite suppressants and hemorrhagic stroke among women ages 18-49 years by well-designed analytic epidemiological research. It led to withdrawal of all products containing PPA in the US and many other countries since 2000. However, the association between PPA and cerebral hemorrhage could not be confirmed by the case-control study conducted in Mexico due to inappropriate recruitment of control group. CONCLUSIONS: During several years case reports have suggested that hemorrhagic stroke could be induced by PPA, and the Yale Hemorrhagic Stroke Project revealed the association by case-control study and provided a useful model for pharmacovigilance. Nevertheless, their finding could not be applied to other population such as elderly women and male population. And they could not provide any evidence on the association between PPA and stroke when PPA was used as cold remedy taken daily dose below 100mg.
Aged
;
Appetite Depressants
;
Blood Pressure
;
Case-Control Studies
;
Cerebral Hemorrhage
;
Cohort Studies
;
Female
;
Heart Rate
;
Humans
;
Japan
;
Korea
;
Male
;
Mexico
;
Pharmacoepidemiology
;
Pharmacovigilance
;
Phenylpropanolamine*
;
Prescriptions
;
Stroke*
;
Vasculitis
5.A Comparison of Infarct Size and Prognosis between Cardiogenic Embolic Infarction and Large Artery Atherosclerotic Infarction.
Ji Hoon JANG ; Byung Woo YOON ; Jae Kyu ROH
Journal of the Korean Neurological Association 2000;18(4):381-385
BACKGROUND: Cardiogenic embolic infarction is the most preventable type of ischemic stroke. This study was under-taken to compare the infarct size, prognosis, and risk factors between cardiogenic embolic infarction (CE) and large artery atherosclerotic infarction (LAA). METHODS:We reviewed the medical records and brain computed tomography/magnetic resonance image (CT/MRI) scans of patients with CE or LAA during the period between January 1996 and May 1998. Patients with lacunar and posterior circulation infarctions were excluded. A slice of brain CT/MRI scan showing the largest lesion was selected in each patient and the area of infarction was then measured. Prognosis was determined by the Modified Rankin Disability Scale (MRDS) and was grouped as either good (MDRS 0, 1, 2) or poor (MDRS 3, 4, 5). RESULTS: The study included 103 patients : 50 with CE (NVAF in 23, VHD with or without AF in 13, prosthetic valve in 6, and others in 8) and 53 with LAA (large artery thrombosis in 29, and artery to artery embolism in 24). The infarct size of CE (23.2+/-14.7 cm2) was significantly larger than that of LAA (11.4+/-10.5 cm2) (p<0.001). The infarct size of NVAF (29.0+/-19.1 cm2) was significantly larger than that of VHD with or without AF (19.2+/-11.5 cm2) (p<0.05). Patients with CE had a worse prognosis (poor in 46%) than those with LAA (poor in 23%) (p<0.05). CONCLUSIONS Our results showed that CE led to larger lesions and worse outcomes. Therefore, we emphasize the importance of primary and secondary preventions of stroke in patients with cardiogenic embolic sources.
Arteries*
;
Brain
;
Embolism
;
Heart Valve Diseases
;
Humans
;
Infarction*
;
Medical Records
;
Prognosis*
;
Risk Factors
;
Secondary Prevention
;
Stroke
;
Thrombosis
6.Three Cases of Rituximab Treatment for Orbital Inflammatory Disease.
Byung Chun PARK ; Kyung In WOO ; Yoon Duck KIM
Journal of the Korean Ophthalmological Society 2012;53(5):721-727
PURPOSE: To report three cases of rituximab treatment in refractory orbital inflammatory disease. CASE SUMMARY: Rituximab treatment was performed in three patients (thyroid-associated ophthalmopathy, orbital myositis, and idiopathic sclerosing inflammation) unresponsive to corticosteroid and radiotherapy. One cycle consisted of intravenous infusion of 1000 mg of rituximab, twice at a two-week interval. The patient with thyroid-associated ophthalmopathy exhibited clinical improvement in visual acuity, color vision, visual evoked potential, and visual field after one cycle of rituximab treatment. The patient with orbital myositis improved showed diplopia with a decrease in the size of the extraocular muscle after two cycles of treatment. The patient with idiopathic sclerosing inflammation showed improvements in visual acuity and visual field defect after one cycle of therapy. There were no severe infections or hematologic adverse effects including neutropenia, or decreased immunoglobulin during the follow-up period. CONCLUSIONS: Treatment with rituximab appears to offer another therapeutic option in patients unresponsive to corticosteroid or radiotherapy.
Antibodies, Monoclonal, Murine-Derived
;
Color Vision
;
Diplopia
;
Evoked Potentials, Visual
;
Follow-Up Studies
;
Graves Ophthalmopathy
;
Humans
;
Immunoglobulins
;
Inflammation
;
Infusions, Intravenous
;
Muscles
;
Neutropenia
;
Orbit
;
Orbital Myositis
;
Visual Acuity
;
Visual Fields
;
Rituximab
7.Pontine Hemorrhage after Surgical Evacuation of Nontraumatic Subdural Hematoma.
Ji Hun JANG ; Byung Woo YOON ; Eun Mi PARK
Journal of the Korean Neurological Association 1999;17(6):920-923
Duret hemorrhage is characterized by an upper brainstem hemorrhage due to increased intracranial pressure by mass effect such as subdural hematoma or a brain tumor. The anteroposterior elongation and downward displacement of the upper brainstem by transtentorial herniation results in the compression and tearing of the paramedian perforating vessels that feed the upper brainstem tegmentum. The consequent hemorrhage that involves the upper brainstem renders recovery to be almost impossible. Following a tricuspid valve replacement surgery, a 56-year-old woman developed a left fronto-temporo-parietal nontraumatic subdural hematoma resulting in transtentorial herniation of the left mesial temporal lobe. A successful surgical evacuation of the hematoma was done with clinical improvement. Two days later, she was referred to neurology with an aggravated right side weakness, dysarthria, and a newly developed extraocular movement disturbance. A brain CT and MRI showed a pontine hemorrhage. We report a case of pontine hemorrhage, a Duret hemorrhage, after the surgical evacuation of nontraumatic subdural hematoma.
Brain
;
Brain Neoplasms
;
Brain Stem
;
Dysarthria
;
Female
;
Hematoma
;
Hematoma, Subdural*
;
Hemorrhage*
;
Humans
;
Intracranial Pressure
;
Magnetic Resonance Imaging
;
Middle Aged
;
Neurology
;
Temporal Lobe
;
Tricuspid Valve
8.Glanuloplasty with Chordectomy in Hypospadias Especially Original and Modified Techniques of Mays' Glanuloplasty.
Gyung Woo JANG ; Jong Byung YOON
Korean Journal of Urology 1986;27(3):433-436
We performed original and modified technique of Mays' glanuloplasty in 6 and 12 cases respectively. The results were as follows: 1. 6 cases of mild from of hypospadias (2 cases of coronal, 4 cases of dist. penile) and 12 cases of severe form of hypospadias (5 cases of prox. penile, 6 cases of penoscrotal, 1 case of perineal) on pre-chordectomy but all cases became severe from of hypospadias (2 cases of prox. penile, 15 cases of penoscrotal, 1 case of perineal) on post-chordectomy. 2. The postoperative complications were 3 cases (50.0%) (1 case of meatal stenosis, 2 cases of meatal necrosis) in original technique of Mays' glanuloplasty and 2 cases of meatal stenosis (16.7%) in modified technique of Mays' glanuloplasty.
Constriction, Pathologic
;
Female
;
Hypospadias*
;
Male
;
Postoperative Complications
9.Effect of Nimodipine on Ischemic Brain Edema of Gerbil.
Il Keon LEE ; Byung Woo YOON ; Jae Kyu RHO
Journal of the Korean Neurological Association 1991;9(4):413-417
The mechanisms involved in brain neuronal damage in ischemia are related to the elevation of cytosolic calcium concentration and calcium antagonist is considered as a promising drug that may alleviate ischemic neuronal damage. Using transient global ischemia model of Mongolian gerbil, we studied the effect of nimodipine, a cerebroselective calcium antagonist, on ischemic brain edema. We treated each gerbil intraperitoneally with nimodipine (lmg/kg) or the same amount of saline 30 minutes prior to ischemia, and transient global ischemia was induced by means of clipping both common carotid arteries either for 10 minutes or for 45 minutes. Three hours after reperfusion, the animals were decapitated and the water content of the bain was determined by oven dry method. With 10 minute ischemia the brain water content in nimodipine pretreatment group (78.6 +/- 0.2%) was lower than that in saline pretreatment group (79.1 +/- 0.4%) significantly (p<0.05). But with 45 minute ischemia nimodipine pretreatment did not reduce the postischemic increase of water content compared with saline pretreatment (79.8 +/- 0.4% and 79 6 +/- 0.4%, respectively; not significant). Our results suggest that nimodipine pretreatment may suppress the development of ischemic brain edema and its effect depends largely on the extent of brain ischemia.
Animals
;
Brain Edema*
;
Brain Ischemia
;
Brain*
;
Calcium
;
Carotid Artery, Common
;
Cytosol
;
Gerbillinae*
;
Ischemia
;
Neurons
;
Nimodipine*
;
Reperfusion
10.Neuroprotective Effects of Lamotrigine in Transient Global Ischemia.
Yong Seok LEE ; Byung Woo YOON ; Jae Kyu ROH
Journal of the Korean Neurological Association 1998;16(2):113-118
BACKGROUND AND PURPOSE: Current therapy for acute ischemic stroke is highly focused on neuroprotective agents, and many ion channel blockers have been challenged for experimental models. In this study, we tried to reveal the neuroprotective effect of lamotrigine, a voltage-sensitive sodium channel blocker, for transient global ischemia of Mogolian gerbil. METHODS: Lamotrigine (50mg/kg) was administered via gastric tube 30 minutes before and after global ischemia (for 10 min) under body temperature monitoring. Sham-operated and non-treated ischemia group were compared. Seven days after reperfusion, gerbils were killed with perfusion/fixation technique and representative sections were cut through the hippocampus. Hematoxylin-Eosin staining was done for microscopic examination and number of viable neurons in CA1 area was counted. RESULTS: Neuronal density was different between sham-operated (n=11), non-treated ischemic (n=11), and lamotrigine-treated (n=26) group (107.8+13.1/mm vs. 21.5+23.0/mm vs. 82.0+13.1/mm, p<0.01). Both pre-(n=17) and post-treated group (n=9) showed significant neuroprotective effect compared with non-treated group. Neuronal density of pre-treated group was slightly higher than in post-treated group, though statistically not significant (84.6+13.0/mm vs. 77.3+12.7/mm, p=0.13). CONCLUSION: These results show that lamotrigine may have some effects reducing the delayed neuronal death in transient global ischemia. Considering the mechanism of action, we suggest that activation of voltage-sensitive sodium channel and release of glutamate at early phase of ischemia may be related to the delayed neuronal death.
Body Temperature
;
Cerebral Infarction
;
Gerbillinae
;
Glutamic Acid
;
Hippocampus
;
Ion Channels
;
Ischemia*
;
Models, Theoretical
;
Neurons
;
Neuroprotective Agents*
;
Reperfusion
;
Sodium Channels
;
Stroke