We report a case of histopathologically proven Buruli ulcer (BU) in a 25-year-old man which was found at the proximal right thigh and groin – an unusual site of occurrence. Laboratory results including Gram and ZN stains were negative while a culture on Lowenstein Jensen media at 33oC from the tissues produced a positive growth of Mycobacterium ulcerans. Histology of the edges of the ulcer showed a granulomatous lesion consistent with BU. This highlights the differentiation of Buruli ulcer from tropical ulcer and, to a lesser extent other forms of skin malignancies and benign skin lesions. The ulcer presented by the young man was Buruli ulcer.