Objective To observe the effects of perindopril on changes of endothelin(ET)and atrial natriuretic peptide (ANP) in patients with essential hypertension (EH).Methods Thirty patients with EH were given with perindopril for four consecutive weeks.Plasma ET and ANP were examined with radioimmunoassay (RIA) before and after treatment,with thirty healthy volunteers as controls.Results Plasma levels of ET and ANP were higher in EH groups before treatment than those in controls (P＜0.01),and decreased significantly after treatment than those before treatment (P＜0.01).Conclusion The influence of perindopril on ET and ANP is correlated to its hypotensive effects in EH patients.

Objective Study the effect of Chuanxiongsu(ferulic acid) combined perindopril or perindopril alone in the treatment of essential hypertension (EH). Methods Sixty patients with EH were divided into two groups randomly and single blindly: group A received Chuanxiongsu combined with perindopril, while group B received perindopril alone(4-8 mg/d) only for four weeks. Plasma endothelin-1 concentration(ET-1) and nitric oxide (NO) concentration were determined with radiommunoassay(RIA). Blood pressure was monitored before and after treatment. Thirty healthy volunteers served as controls. Results SBP in group A was lower than that in group B(138.9?8.1 vs group B 143.1?8.5)mm Hg, P