1.Effect of calf serum on neurological deficits and rehabilitation in patients with intracerebral hemorrhage
Hongying ZHANG ; Shouzhong WANG ; Buxian TIAN
Chinese Journal of Biochemical Pharmaceutics 2017;37(4):20-22
Objective To investigate the effect of calf serum therapy on patients with cerebral hemorrhage in patients with neurological impairment and rehabilitation.Methods 110 cases of cerebral hemorrhage patients from August 2014 to April 2016 in our hospital,were randomly divided into study group and control group using SAS10.0 software,each has 55 cases,two groups were given routine treatment measures of oxygen,dehydration,blood pressure,the study group also received deproteinized calf serum injection treatment,observe the clinical effect of two groups of the patients.Results Before treatment,the two groups had no statistical significance in patients with NIHSS score,BI index difference,for 14 days and 1 months after treatment,the study group of patients with NIHSS score were lower than the control group(P<0.05),the study group of patients with BI score were higher than the control group(P<0.05); the 14 day after treatment.Two groups of patients with cerebral edema were treated for 3 days were significantly reduced(P<0.05); after 3 months of treatment,the basic cure rate of group 58.18%,significant improvement rate was 27.27%,the control group were 40%,significant progress was 34.55%,compared the two groups,the study group than the control group(P<0.05).Conclusion The use of calf serum therapy in patients with cerebral hemorrhage is helpful to the recovery of neurological function and activity of daily living.
2.Correlation between free fatty acid metabonomics in patients with acute cerebral infarction
Journal of Apoplexy and Nervous Diseases 2021;38(12):1081-1084
Objective To explore the relationship between free fatty acid metabolites and the acute cerebral infarction based on tandem mass spectrometry.Methods Collecting 460 objects admitted to the first affiliated hospital of jinzhou medical university from October 2019 to January 2020.According to the presence of new cerebral infarction in the head imaging examination,they were divided into two groups:acute cerebral infarction group and control group.The tandem mass spectrometry was used to detect plasma 25 free fatty acids metabolites.Orthogonal partial least squares discriminant analysis (OPLS-DA),Receiver operating characteristic curve (ROC) and logistic regression were used to screen the differential metabolites.Results There are 5 free fatty acid metabolites and the comprehensive indicators W significantly correlated with the incidence of cerebral infarction.The area under curve (AUC) of each metabolite for predicting cerebral infarction was as follows:W (0.917),palmitic acid (0.892),stearic acid (0.878),linoleic acid (0.864),oleic acid (0.840),arachidonic acid (0.806).Conclusion Linoleic acid,palmitic acid,stearic acid,arachidonic acid,oleic acid may be related to the occurrence and development of cerebral infarction,and the study of their metabolic processes may provide a basis for exploring the pathogenesis of cerebral infarction.