Placental peptide(PP), which was extracted from the placenta of healthy women, was an immunomoderator. It had similar properties as transfer factor(TF) in physiochemistry, bioactivity and immuno-conpetence. This study showed that PP increased the amount of leucocytes and splenic nucleated cells obviously, raised the complement activity, and improved the phagocytosis of phagocytes in the mice. The specific antibody, especially the level of amboceptor antibody of PP treated mice was higher than that of control group, while there was no significant differance between TF group and the control group. It is concluded that PP is superior to TF in promoting the function of humeral immunity and it is a valuable immunomoderator.

BACKGROUND: It has been discovered in experimental researches that qiang chang heji acts on prevention and treatment of brain injuries induced by insufficient blood supply and improvement of blood rhelogical property.OBJECTIVE: To study on the effects of qiang chang heji on peripheral red blood cell in rats with insufficient blood supply to brain so as to probe into its mechauism on improving blood rhelogical property.DESIGN: A randomized controlled trial.SETTING: Central Laboratory of General Hospital of Chengdu Military Area Command of Chinese PLA.MATERIALS: The experiment was performed in Central Laboratory of General Hospital of Chengdu Military Area Command of Chinese PLA from July to September 2003. Totally 50 SD white rats of either sex were employed, weighted varied from 150 g to 170 g.METHODS: The common carotid artery(CA) on the right side was ligatured to induce insufficient blood supply in the brain. The control and qiang chang heji(QCHJ) group were designed for comparison. On the same day of CA ligature, in treatment group, QCHJ of various dosages were applied daily for gastric perfusion; and in the control, physiological saline was applied. Three or seven days later, the parameters of peripheral red blood cell and its rhelogical property were analyzed with equipment.the sham-operation group, mean cell hemoglobin (MCH), haematocrit(HCT) (%) and RBC aggregation index were in the tendency of increase and mean cell hemoglobin concentration (MCHC) (g/L) was increased obviously (375±7 vs 363±13) (P ＜ 0.05) .In the treatment group of 10 g/kg QCHJ, HGB(139.2±12.4 vs 153.6±9.6), MCHC(355±7 vs 375±7) and haematocrit(HCT) (35.4 ±0.9 vs 42.8 ±4.5) were significantly lower the control compared with the sham-operation group, both rigidity index and aggregation index of RBC were in the tendency of further increase. In treatment of QCHJ 10 g/kg, MCHC(354±4 vs 361 ±4), RBC rigidity index (1.02±0.35 vs 4.54±3.04) and aggregation index (2.76±0.66 vs 4.67 ± 1.21 ) were significantly lower than the control( P ＜ 0.05).CONCLUSION: Treatment with QCHJ can prevent changes in peripheral red blood cell in rats with insufficient blood supply in the brain and reduce MCHC and RBC rigidity index and aggregation index so as to improve RBC deformability and rhelogical property.

OBJECTIVE： The preventive and therapeutic effects of a compound traditional Chinese medicine preparation， Yingganfukang(YGFK)， on mice experimental liver fibrosis were studied METHODS： The acute liver damage and fibrosis rat models were established by giving single or multi－ dose of CCl4 orally and the liver dysimmunity model was established by giving BCG and LPS intravenously Rats were divided into YGFK group and control group The serum ALT， AST and ALP of the mice were examined The liver tissues taken from the liver fibrosis mice were committed to pathological examination RES_ ULTS： The serum ALT， ALP of the YGFK(2g/kg· d) group and control group were （ 6 153± 3 491） IU/L、 （ 202± 24） IU/L and （ 9 275± 2 744） IU/L、 （ 421± 67） IU/L， respectively in the acute liver damage mice with significant differences