Objective To explore the therapeutic effect of drug combined with psychological intervention on the patients with chronic urticaria.Methods 119 patients who were diagnosed and diagnosed in our hospital from October 2015 to November 2016 were randomly divided into experimental group and control group according to the time of hospitalization.example.The experimental group for drug and psychological intervention in the double treatment;the control group for simple drug treatment.Results There were different degrees of mental health problems in patients with chronic urticaria, and there were many significant differences in mental health problems, such as tension, insomnia, anxiety and mood, muscle system symptoms.In the experimental group and the control group, there was no significant difference between the experimental group and the control group.However, the data of the experimental group and the control group were statistically significant (P<0.05), but there was no significant difference between the experimental group and the control group.In addition, after 4 weeks of treatment, the experimental group and the control group of patients with significant differences in treatment, respectively, 91.53% and 79.66%.There was significant difference between the two groups (P<0.05).Conclusion Compared with the single drug treatment, the effect is more significant which drug combined with psychological intervention was used on the treatment of the patients with chronic urticaria, and has certain positive significance.It can be popularized in clinical practice according to the actual situation.