1.Findings of study of knowledge and attitude on health promoting workplaces of Khentii aimag
Orkhonchimeg N ; Saijaa N ; Oyunchimeg M ; Bujinlkham B ; Dashnamjilmaa D ; Tsendjav J ; Alimaa G
Mongolian Medical Sciences 2013;163(1):62-66
BackgroundThe target group of the project, working age population, is more vulnerably exposed to the risk factors of NCDs due to deficiency of physical activities, stress, unhealthy eating, etc. The current study was carried out to assess the knowledge and attitude on health promoting workplaces among the employees of public and non-governmental organizations and businesses operating in Kherlen soum of Khentii aimag, identify their needs and make conclusions.Materials and MethodsThe cross-sectional study used questionnaires for 195 employees of 10 public agencies and 3 business entities of Kherlen soum of Khentii aimag, focus group discussions among 32 employees and individual interviews with 13 managing officials.ResultsWomen composed 38% (74 persons) and men composed 62% (121 persons) of the participants of the study. As for the duration of the service, 115 people or 58.7% have served for 1-10 years, 49 people or 25% have served for 11-20 years, 21 persons or 10.7% have served for 21-30 years and 6 persons or 3.1% have worked for 30 years. As for the knowledge of health promoting workplaces, the absolute majority of the participants demonstrated medium or low level of knowledge with statistical significance (p<0.01) among ages, with women demonstrating higher level of knowledge and increasing trend with the years of work. Absolute majority of the participants of the qualitative survey answered that possess insufficient information of health promoting workplaces. Majority or 54.2% (105) of the participants understand health promoting workplaces as provision of working conditions and organization of preventive health check ups. Creating healthy workplaces will have no negativeimpact but increased productivity, higher morale, better wellness, according to the respondents. Job satisfaction as an impact of health promotion at workplace was supported by 48.4% of the employees at 20-30 years age and 54.2% of the employees who have served for 11-20 years. 57.7% (112) of the respondents disagree that their workplaces created health promoting conditions. The knowledge of the majority of the participants in insufficient as 89.3% answer that WHP is provision of healthy environment for working. Health promotion is not implemented sufficiently at the policy level and is limited merely to improvement of physical environment and solution of social problems, with insufficient behavior targeting actions and participation of employees in health promoting activities.Conclusions:1. The knowledge on health promoting workplaces is insufficient.2. The answers of the respondents that lack of health promotion at workplaces will reduce productivity (69.2%) and adversely affect the health of the employees (44.7%) demonstrate the need in WHP.3. The further activities necessary for further development of health promoting workplaces were identified as provision of comprehensive knowledge, cooperation with professional organizations and learn from experiences of health promoting workplace models, mutual learning and solution of the financial issues.
2.Study result of relationship of respiratory diseases among 0-16 year old children and climate change in Mongolia
Ihinkhorloo B ; Nyamragchaa CH ; Burmaajav B ; Enkhtuya P ; Amardulam N ; Davaasuren M ; BaatartsolD ; Оdnoo BRAUN ; Bujinlkham B
Mongolian Medical Sciences 2012;162(4):43-53
IntroductionClimate change has already been started in Mongolia. The frequency of natural disaster such as drought, zud disaster, snow storm, hot and cold extreme weather, and earthquake has increased every year. As per daily information of meteorological stations, annual air temperature has been increased since 1960. Children is more sensitive in varies environmental impacts compared with adults and adverse effects caused by climate changes can be remained in all lives and it can be irreversible. Relation between climate change and children’s health is one of the issues which have not been studied yet. The purpose of this study was to investigate relationship between respiratory diseases of children and climate change as well as some air pollution parameters.Materials and MethodsStudy was carried out by cross-sectional study design. According to the regional climate classification of Mongolia, Zavkhan, Selenge, Dornod and Umnugovi provinces was selected as a target area of the study. The relationship between respiratory disease of children and climate change as well as some air pollution parameters were analyzed based on statistical data of Health Departments and Family doctors’ documentation of those provinces for prevalence and incidence of respiratory disease among the children aged 0-16 and daily information of climate parameters such as air temperature, air pressure, relative humidity and precipitation status taken from selected provinces Meteorological Departments and data for air quality basic parameters (SO2, NO2, CO2, PM 10) taken from Air Quality Department of Ulaanbaatar city.ResultsRespiratory diseases among the target ages were registered highly (70.7%) in age of 0-5 years. According to the comparison results in incidence rate of respiratory diseases by region, upper respiratory tract diseases (J09-J18) and lower respiratory tract diseases (J20-J22) were registered in Umnugovi aimag (254.75 and 50.42cases per 10000 children)which belong to very dry and warm regions and Dornod aimag (121.62 and 26.11 cases per 10000 children) which belong to dryish cold regions in 2010. Respiratory tract diseases (J09-J18, J20-J22) were correlated weak indirectly with average air temperature and minimum average air temperature. It was correlated weak directly with wind speed and air pressure. Respiratory tract diseases (J09- J18, J20-J22) were correlated directly with SO2 concentration in air (r=0.269, p>0.001) and NO2 (r=0.286, p>0.001).ConclusionClimate change and air pollution could be influenced on the increase of morbidity of respiratory tract infections. Some air pollution parameters such as SO2, NO2 and PM2.5 and air temperature, air pressure, relative humidity and wind speed are the causes of respiratory tract infections among the children aged 0-16.
3.Pharmaceutical coating: A review
Maralgua A ; Maral L ; Munkhzaya B ; Bujinlkham B ; Saikhanbayar P ; Lkhaasuren R ; Akhsholpan B
Mongolian Pharmacy and Pharmacology 2024;24(1):63-67
Coating agents are used in medicine to protect tablets from air or moisture, to mask bitter tastes, or to
provide special characteristics for drug release, such as enteric release. There are three main coatings: sugar coating , film coating, and enteric-coating. In this review, we discuss the status of the most commonly used pharmaceutical film coating materials and data were obtained from electronic databases such as PubMed, Google Scholar, and other scientific websites. There are various materials for creating a tablet coating, but the most commonly used material is a water soluble polymer which is used for making a water-soluble film coating.
4.Incompatibility of drug excipients: A review
Maral L ; Maralgua A ; Munkhzaya B ; Bujinlkham B ; Saikhanbayar P ; Lkhaasuren R ; Akhsholpan B
Mongolian Pharmacy and Pharmacology 2024;24(1):68-71
Excipients are important in the composition of drugs and are the most important requirements for maintaining
the stability of drug form, dosage, and physicochemical parameters. Excipients act as protective agents,
bulking agents and can also be used to improve bioavailability of drugs in some instances Auxiliary
substances included in the composition of medicines are classified as natural, animal, synthetic and
semisynthetic. Excipients can become inactive due to chemical, microbiological and physiological effects.
Commonly used pharmaceutical excipients are fillers, stabilizers, preservatives, flavor and aroma modifiers,
binders, disintegrants, lubricants, lubricants, solvents, and coating agents. Excipients can be considered as
indispensible component of medicinal products and in most of the formulations they are present in greater
proportion with regards to active pharmaceutical ingredient, as it forms the bulk of the formulation it is
always necessary to select an excipient which satisfies the ideal properties for a particular excipient. In this
review, materials about coating agents widely used in pharmaceutical practice were compiled from electronic
databases such as Pubmed, Google Scholar, and other scientific web pages, using keywords such as Drug
excipient interaction, Stability in Oral Solid, and Excipient. .
5.Review of medicinal plant decontamination methods to ensure microbiological aspects
Munkhzaya B ; Saikhanbayar P ; Maral L ; Maralgua A ; Bujinlkham B ; Lkhaasuren R ; Akhsholpan B
Mongolian Pharmacy and Pharmacology 2024;24(1):72-79
The incorporation of botanical elements such as Inula helenium L., Astragalus mongolicus Bge.,
Iris tenuifolia Pall., Ribes diacanthum Pall., and Oxytropis pseudoglandulosa Grubov plays a pivotal role in the formulation of immune-enhancing and kidney-protective Mongolian traditional medicines. These herbal constituents bear rich historical significance in traditional remedies. Ensuring the purity of these herbs is a vital stride in the production of efficacious supplements and medications. Thus, meticulous decontamination of microorganisms assumes paramount importance. The selection of an appropriate sterilization method is important for manufacturers. Sterilization methods divide within three main categories: thermal, chemical, and radiation. This spectrum encompasses many techniques, ranging from moist heat and dry heat to gamma irradiation, ethylene oxide, ozone, and UV treatment. This comprehensive review discusses the efficacy of gamma irradiation, dry heat, moist heat, and chemical treatments, presenting a comparative analysis of their merits. Practically, heat sterilization emerges as a simple and cost-efficient choice. The utilization of an autoclave, subjecting powdered spice paprika to temperatures between 108-125°C for 120 seconds, yielded a substantial reduction in microbial load without compromising the integral bioactive compounds. Gamma
irradiation, a common practice in the healthcare and pharmaceutical sectors, stands as another choice in the area of sterilization techniques. Beyond sterilization, upholding rigorous standards of sanitation and hygiene remains a key in the preparations of medicinal plants.
6.Study of some bioactive substances contained in dry extracts of cultivated Inula helenium L. plant
Bujinlkham B ; Sugarmaa B ; Batdorj D ; Ganchimeg G ; Saikhanbayar P ; Munkhzaya B ; Maral L ; Badamtsetseg S ; Lkhaasuren R ; Akhtolkhyn T
Mongolian Pharmacy and Pharmacology 2024;25(2):29-37
Introduction:
Since 1993, the Inula helenium L. plant has been planted in the production area (Bulgan
Province, Dashinchilen Sum) of the Traditional Hatchery Science and Production Corporation’s medicinal
plant introduction and cultivation experience. At the Drug Research Institute, there is also a botanical institute
for medicinal plants where it is grown. In traditional Mongolian medicine, the roots and rhizomes of Inula
helenium L. are used to reduce inflammation, boost immunity, enhance hunger, and improve intestinal
motility. Inula helenium L. roots and rhizomes contain biologically active compounds such as monoterpenes,
sesquiterpenes, phenols, flavonoids, and polysaccharides.
Methods:
The roots and rhizomes of Inula helenium L. were extracted with water and 70% ethanol at the
following ratios 1:10 (2% of WAC), 1:8, and 1:6 by partial maceration at 700C for 2 hours each, extracted
and concentrated. The dry extract was obtained by the spray drying procedure. High-performance liquid
chromatography for determining the content of alantolactone, thin-layer chromatography for qualitative
analysis. Spectrophotometer for determining the content of polyphenolic compounds, colored compounds
with Folin-Ciocalteu reagent for qualitative analysis. Spectrophotometer for determining the content of inulin, and colored compounds with phenol and sulfuric acid solutions for qualitative analysis.
Conclusion
In determining the content of polyphenolic compounds, inulin, and alantolactone in the dry extract
taken from the roots and rhizomes of cultivated Inula helenium L., the content of polyphenolic compound in dry extract A was 2.50±0.08%, and alantolactone was 1.39±0.11% in the raw material of the plant, while B dry the extract had a high concentration of inulin of 58.51±0.66%.