Objective To explore the comprehensive intervention methods among people with high-risk of AIDS ,and to evaluate the effects of the intervention to provide reference basis for the scientific prevention of AIDS .Methods The 1-year comprehensive intervention including the health education ,psychological and medical consultation ,and condom promotion was conducted among the commercial sex workers(CSW) and the injecting drug users(IDU) in the Xunyang district .The questionnaire survey was performed before and after the intervention ,and then the effects of intervention were evaluated .Results Through the comprehensive interven-tion ,the total awareness rate of the AIDS knowledge among CSW was increased from 70 .75% to 84 .75% (χ2 =22 .66 ,P<0 .01) while which among IDU was increased from 77 .25% to 88 .50% (χ2 =17 .84 ,P<0 .01) .The frequencies of using condoms with cli-ents ,spouse or boyfriend in recently one month were significantly increased (Z= -2 .73 ,P<0 .01 ,Z= -2 .02 ,P=0 .04) .The fre-quency of sharing needle in recently six months among IDU was significantly decreased (Z= -3 .67 ,P<0 .01) and the frequency of using condoms in recently one year among IDU was significantly increased (Z= -2 .96 ,P<0 .01) .Conclusion The comprehensive intervention may effectively increase the awareness rate of the AIDS knowledge among CSW and IDU and change their dangerous behaviors possibly leading to AIDS transmission .