OBJECTIVE To study the disinfectant resistance of multi-drug resistant Escherichia coli strains isolated clinically,and to find out the efficacy of disinfectants commonly used in killing multi-drug resistant E.coli strains.METHODS Minimal inhibitory concentration(MIC) and suspension quantitative germicidal test were used.Compared with standard strains,strains of multi-drug resistant E.coli isolated clinically were determined the resistance to four kinds of disinfectants including benzalkonium bromide etc.RESULTS A higher MIC of benzalkonium bromide compared with standard strains was observed in 61.9% of all 21 multi-drug resistant E.coli strains,and as for povidone iodine and NaClO,the ratio was 71.4% and 14.3%,respectively.All multi-drug resistant E.coli strains had the same MICs of peroxyacetic acid with standard strains.The above-mentioned 4 disinfectants commonly used at the routine concentrations killed 100% of the resistant strains of E.coli within 5 minutes.CONCLUSIONS The resistance to benzalkonium bromide and povidone iodine of multi-drug resistant E.coli isolated clinically is higher than standard strains;and 4 kinds of disinfectants commonly used are effective for multi-drug resistant E.coli strains isolated clinically.

Objective To evaluate the efficacy and safety of azithromycin sequential therapy in treatment with my-coplasma pneumonia. Methods A total of 134 cases with mycoplasma pneumonia were selected in respiratory depart-ment of our hospital during April 2012 to June 2013, and then divided into observation group and control group ac-cording to the different treatment, which received azithromycin sequential therapy and erythromycin intravenous infu-sion respectively. The clinical effects and the incidence of adverse reactions were comparatively analyzed. Results 14 d after treatment,the treatment efficiency of observation group reached 95.71%,which was significantly higher than that in control (79.69%)(P<0.05).The fading time of coughing,the fading time of crackles and rale and the time of fever descending to normal were significantly shorter than that in control (P<0.05). Meanwhile,the adverse reaction rate of the observation group, include joint pain, rash, gastrointestinal reactions, elevated serum alanine aminotransferase,were significantly lower than that in the control group (P<0.05). Conclusion Azithromycin sequential therapy have a good clinical efficacy in treatment with mycoplasma pneumonia, shorten the symptoms disappearance time and hospi-talization time and reduce toxicity,which is widely used in clinical practice.

Combining with the data based on data mining,to collect the clinical experimental research ralating to thermal moxibustion from June 2010 to March 2015, and extract the representative clinical experimental research of clinical diseases. To summarize advances in clinic study of Thermal Moxibustion in recent five years.

Objective:To summarize the clinical characteristics, diagnosis and treatment of esophageal rupture caused by intestinal preparation, in order to improve the understanding of this disease.Methods:We combined with the clinical data of one patient with esophageal rupture caused by intestinal preparation admitted to Yijishan Hospital of Wannan Medical College in January 2020, and reviewed the relevant literature reports from 2009 to 2019 in CNKI database with esophageal rupture as the key word.Results:The patient suffered from esophageal rupture due to severe vomiting after magnesium sulfate enema preparing for endoscopic submucosal dissection.The patient was cured by endoscopic titanium clip therapy and closed thoracic drainage.A total of 89 articles involving 929 cases of esophageal rupture were retrieved, and it was found that males were more than females, the incidence of spontaneous>foreignness>traumatic>iatrogenic, the number of surgical cases(736 cases) was more than that of non-surgical cases(193 cases), the cure rate(86.65%) was higher than the death rate(13.35%).Conclusion:Esophageal rupture is one of the clinical emergencies with atypical clinical symptoms.Only detailed medical history inquiry and timely, effective imaging examination can make early diagnosis and early treatment, so as to reduce the fatality rate of the disease and improve the prognosis of patients with the disease.

OBJECTIVETo analyze the diseases and effects of the manipulations to promoteby filiform needles, with the help of data mining technique.

METHODSLiterature about different manipulations to promoteby filiform needles in recent 60 years was collected in China National Knowledge Infrastructure(CNKI). Then databases were established to mine the relativities among the diseases, subjects, acupoints selection law,routes and directions of meridianand effects.

RESULTS①Total 489 articles were included. The basic manipulations with the frequency of 630 were on the top. The auxiliary and four methods ofrespectively appeared 70 times. The diseases in the internal medicine were treated with the basic and auxiliary methods of the higher frequencies, 311 and 44 times separately. While the four methods ofwere mostly used in the surgical area, 37 timestotally. ②The diseases treated from high to low by lifting, thrusting and twirling represented retention of urine, sequelae of stroke, pain in waist and lower limbs, of which the effect for retention of urine was better than those of the other two, and the lifting and thrusting method was superior to twirling. ③As for the auxiliary methods, 25 times were found about vibration needling; 18 times, twisting. The highest frequency of 6 times for the vibration needling was on the sequelae of stroke; while 4 times for the twisting, stranguria. ④As to the four methods of,was most frequently applied, and its highest frequency of 18 was onsyndrome.

CONCLUSIONSManipulations to promoteby filiform needles are crucial to achieving the effects of acupuncture. The basic methods are widely used in clinic and have been seen good efficacy. While the auxiliary means assist to promoteto stimulate the body,among which the four methods ofare mainly to smooth the meridians and driveof patients with surgical diseases and take meridian blocking the priority.