From 1990 to 2000, 513 cases of aplastic anemia were diagnosed and treated in Blood transfusion and Hematology Centre of Ho Chi Minh city, composing of 144 children and 369 adults with 279 males and 234 females. By bone marrow aspiration and biopsy, we diagnosed these cases as follow: aplastic anemia 449 cases (87.5%), hypocellularity of bone marrow: 45 (8.8%), one lignea hypocellularity of bone marrow: 19 (3.7%). From these cases, we have found that: - ’s difficult to point out accurately the cause of aplastic anemia and this is still the question for many studies in future. - All the patient was treated mainly blood transfusion, corticoid and androgen (77.5%) with complete and partial response was 25.5%. Besides, 32 cases were treated with corticoid + Sandimum given better results with complete response (32.7%).
Bone Marrow Diseases ; therapeutics

The study was carried out in 65 aplastic anemia patients admitted into B¹ch Mai hospital during the period 1995-1999 on the issues of immunological characteristics. The results can be summarized as follows: The count of lymphocytes and the majority of sub-groups of lymphocytes were decreased compared with the control group (p<0.05 - 0.01). The TCD4/TCD8 ratio is decrease compared with the control group. The level of IgG in plasma increased. In the bone marrow, the count of subgroup of lymphocytes decreased compared with the control group. Comparing between peripheral blood and bone marrow, it can be seen that the percentage of T lymphocytes and its sub-groups decreased significantly. The change of the percentage of B lymphocytes however, it is not significant.
Bone Marrow Diseases ; Etiology

We had drawn out some following remarks from the our studied group of patients with bone marrow failure; - There are 89.29% patients with bone marrow failure in three blood cell lineages; and 35.71% of the patients is servere aplastic anemia. - 14.29% patients with bone marrow failure were finished in the diagnosis of acute leukemia(M1= 50%, M2= 50%). - The persentages of the patients with bone marrow failure died from infection (37.5%) and hemorrhage (50.0%) are still high. Almost of the patients were died in the stage from 24 months to 48 months after having the diagnosis.
Bone Marrow Diseases ; diagnosis ; bone marrow

No abstract available.
Bone Diseases ; Bone Marrow ; Bone Regeneration ; Necrosis

There were 39 aplastic anemia patients with immunopathology, who was treated by immunosuppresion such as: Spleenectomy, thymus transplantation using cyclosporine A. The results show that: immunosuppression has successful rate of 50-60% in aplastic anemia after internal treatment was not effectiveness.
Bone Marrow Diseases ; Immunosuppression ; Therapeutics

After 2 months, more patients in the cyclosporine group had a complete or partial remission in response to the treatment than did patients in the prednison group (53,85% and 7,69%; P<0,05), after 3 months this ratio is 69,23% and 16,67%; P<0,01. This difference was confirmed at 6 months 91,66% and 60%; P<0,05), after 12 months: 100% and 50% P>0,05. Hb concentration > 90g/l is 81,8% granulocyte counts >1,56G/l is 72,72%, platelet counts >100G/l is only 36,36%. 2 patients with responses in the cyclosponrine group relapsed after 24 months of treatment. Survival rate of patients in the cyclosporine group is 15/16 (93,57%) and in the prednison group is 6/15 (40%), P<0,05. Conclusion: Immunosuppressive treatment of aplastic anemia with cyclosponrine appears to be more effective than prednison and may represents a treatment of choice for patients with idiopathic aplastic anemia who are not eligible for bone marrow transplantation.
Bone Marrow Diseases ; Therapeutics ; Cyclosporine ; Hospitals

From 11/95 to 11/97 we treated 27 patients with idiopathic aplastic anemia in which 13 treated with idiopathic aplastic anemia in which 13 treated with prednisolon and 14 cases with prednisolon. The results showed that the number of WBC, neutrophils and platelets have not increased in the group treated with cyclosporin A in the course of three months treatment. The group treated with cyclosporin A gave better than the results in comparison with group treated with prednisonlon after one month of treatment.
Bone Marrow Diseases ; Therapeutics ; Cyclosporine ; Blood Platelets

From 26 patients with bone marrow failure, we had drawn some following remarks:- Over 50% of the patients is in the ages from 61 to 75 years old. (youngest: 42: oldest: 82 years old).- There were 38.46% of the patients that were used to contact with some causes of AA in their history particalarly 11.54%- using cloramphenicol; and 7.69% used to live in the area with American orange toxicant. - 100% of the patient with anemia; 15.36% with anemia + hemorrhage; then anemia + infection (7.69%) and anemia + hemorrahage + infection(7.69%).
Bone Marrow Diseases ; diagnosis ; Epidemiologic Studies

No abstract available.
Bone Marrow* ; Histiocytes* ; Niemann-Pick Diseases*

No abstract available.
Biopsy ; Biopsy, Needle ; Bone Marrow/metabolism ; Bone Marrow/pathology ; Bone Marrow Diseases/diagnosis ; Bone Marrow Examination* ; Comparative Study ; Diagnosis, Differential ; Hematologic Diseases/diagnosis* ; Human ; Kidney Failure, Chronic/pathology