Objective To investigate the allergens of asthmatic children of the local area, and provide a reliable objective basis for the prevention, treatment and care of children with asthma. Methods Allergen skin prick test was performed on 217 asthmatic children in our hospital out-patient clinic and hospital from February,2008 to September,2009. All children were divided into three groups by age, there were 48 cases with asthma in the five-months to three-year-old group, 57 cases with asthma in the 3 year-old group, and 112 cases with asthma in the 5 to14 year-old group. The production of allergens developed 10 kinds of inhaled,7 kinds of food allergen with Beijing Union Medical College Hospital Research Center. Results The total positive rate of allergen skin prick test of asthmatic children was up to 89.4%. Conclusions Among the allergic factors, the inhaling allergens are the main factors at wheezing episodes in the local area, and dust mites, indoor dust are the main allergens in the inhaling allergens, in the allergic factors of food, sea shrimp is the important factor that could not be ignored to the wheezing episodes. Therefore, helping parents and children to avoid or reduce dust mites, room dust and sea shrimp exposure is the most basic measures for the prevention, treatment and care of children with asthma.

Objective:To explore the influencing factors of severe pneumonia in children with respiratory syncytial virus (RSV) infection.Methods:A retrospective case-control study was used to collect 210 children with RSV infected pneumonia admitted to Hebei Children′s Hospital from October 2017 to October 2020. Among them, 70 children with severe pneumonia were included in the severe pneumonia group, and 140 children with common pneumonia were included in the common pneumonia group; the baseline data and relevant laboratory indicators of the two groups were compared; Logistic regression was used to analyze the influencing factors of severe pneumonia in children infected with RSV.Results:The proportions of wheezing, congenital heart disease, respiratory failure, heart failure and pleural effusion of children in severe pneumonia group were higher than those in common pneumonia group, and the forced vital capacity (FVC) and forced expiratory volume in the first second (FEV 1) were lower than those in common pneumonia group (all P<0.05); the levels of C-reactive protein (CRP), CD8 + cells, RSV load and Beclin-1 in severe pneumonia group were higher than those in common pneumonia group, and the levels of CD4 + cells and 1, 25-dihydroxyvitamin D [1, 25-(OH) 2D] were lower than those in common pneumonia group (all P<0.05). After treatment, the levels of CRP, CD8 + cells and Beclin-1 in children with severe pneumonia were lower than those before treatment, and the levels of CD4 + cells and 1, 25-(OH) 2D were higher than those before treatment (all P<0.05). Multiple regression model analysis was established. The results showed that congenital heart disease, high CRP level, high CD8 + cells, high RSV load and high Beclin-1 level were risk factors for severe pneumonia in children with RSV infected pneumonia (all OR>1, P<0.05), and high CD4 + cells and 1, 25-(OH) 2D level were protective factors (all OR<1, P<0.05). Conclusions:Severe pneumonia in children with RSV infected pneumonia may be affected by congenital heart disease, CRP, CD4 + cells, CD8 + cells, 1, 25-(OH) 2D, RSV load and Beclin-1.