Objective To compare the efficacy of valsartan,benazepril and felodipine on reversal of left ventricular hypertrophy(LVH)in patients with hypertension and the relevant "aldosterone escape phenomena".Methods One hundred eleven patients with hypertension-related LVH were randomly to receive valsartan(80-160 mg/d,n=36),benazepril(10-20 mg/d,n=39)and felodipine(5 mg/d,n=36).Plasma angiotensin Ⅱ(Ang Ⅱ)and aldosterone(Ald)were determined before and 10-14 weeks 20-26 weeks after treatment.Echocardiographic examinations and blood routine,urine routine,blood glucose,blood lipid,liver function and renal function were conducted in all subjects before and after treatment.Results Blood pressure was significantly decreased in all three groups(P0.05).Valsartan increased plasma Ang Ⅱ at 10-14 weeks and furthermore at 20-26 weeks;benazepril decreased plasma Ang Ⅱ initiatively with trend of rebound at 20-26 weeks;however,plasma Ang Ⅱ was kept constantly in felodipine group.Valsartan decreased Ald and sustained during the all treatment period.On contrary,benazepril initiatively decreased Ald which was rebound to baseline level at 20-26 weeks.No change in Ald by felodipine was found during the treatment.After treatment plasma Ald level was significantly related to the reduction of LVH in both valsartan and benazepril groups.36% patients in benazepril group was found to have "aldosterone escape".Conclusion The antihypertensive effect was similar between valsartan,benazepril and felodipine.Although three medications all reversed LVH,but valsartan,benazepril was more effective than felodipine.There was no evidence of aldosterone escape in the long-term treatment with valsartan.Valsartan might have more advantages in reversal of LVH than benazepril.Felodipine had no effect on the plasma level of aldosterone.

To explore the effectiveness and safety of endovascular recanalization for chronic internal carotid artery occlusion patients under Hasan classification.To evaluate the guiding value of Hasan classification for endovascular recanalization for chronic internal carotid artery occlusion.To investigate the effect of successful endovascular recanalization on systolic blood pressure.Methods We retrospectively reviewed 30 consecutive chronic internal carotid artery occlusion patients.According to Hasan classification and DSA results of our hospital，the study subjects were divided into 4 types：A，B，C and D.After admission，the rate of recanalization，perioperative complication and followup outcomes were collected.Results Among the 30 CICAO patients，83.3% were male and 16.7% were female，with an average age of （58.5±8.6） years.The success rate of endovascular recanalization in 30 patients was 63.3%.According to Hasan classification，the success rate of endovascular recanalization in type A was 81.8%，Type B 75%，Type C 50%，Type D 0%；The perioperative complications was 23.3%，9.1% for type A and 37.5% for type B，Type C 37.5%，Type D 0%，no severe stroke or death occurred during perioperative period.No related complications occurred in all patients during followup.There was statistical significance in systolic blood pressure before and after interventional recanalization in successful group （P<0.01）.There was no significant difference in preoperative and postoperative systolic blood pressure between the unsuccessful group of interventional recanalization （P>0.05）.Conclusion Interventional recanalization for CICAO patients is safe and effective according to Hasan classification criteria.This classification can screen patients suitable for interventional recanalization，predict the success rate of surgery.Successful interventional recanalization may result in a decrease in postoperative systolic blood pressure.

Tongue squamous cell carcinoma is highly malignant and has a poor prognosis. In this study, we aimed to combine whole-genome sequencing, whole-genome methylation, and whole-transcriptome analyses to understand the molecular mechanisms of tongue squamous cell carcinoma better. Oral tongue squamous cell carcinoma and adjacent normal tissues from five patients with tongue squamous cell carcinoma were included as five paired samples. After multi-omics sequencing, differentially methylated intervals, methylated loop sites, methylated promoters, and transcripts were screened for variation in all paired samples. Correlations were analyzed to determine biological processes in tongue squamous cell carcinoma. We found five mutated methylation promoters that were significantly associated with mRNA and lncRNA expression levels. Functional annotation of these transcripts revealed their involvement in triggering the mitogen-activated protein kinase cascade, which is associated with cancer progression and the development of drug resistance during treatment. The prognostic signature models constructed based on WDR81 and HNRNPH1 and combined clinical phenotype-gene prognostic signature models showed high predictive efficacy and can be applied to predict patient prognostic risk in clinical settings. We identified biological processes in tongue squamous cell carcinoma that are initiated by mutations in the methylation promoter and are associated with the expression levels of specific mRNAs and lncRNAs. Collectively, changes in transcript levels affect the prognosis of tongue squamous cell carcinoma patients.
Humans ; Biomarkers, Tumor ; Nerve Tissue Proteins ; Prognosis ; Squamous Cell Carcinoma of Head and Neck/pathology* ; Tongue Neoplasms/pathology*

【Objective】 To develop a prediction model of allogenic blood transfusion in elective patients based on machine learning, so as to guide clinicians to prepare blood for perioperative patients more reasonably. 【Methods】 Relevant data of all surgical patients from 2012 to 2018 were extracted from the big data integration platform of our hospital, to construct the surgical blood database based on Python V3.8.0. All data were analyzed using Excel and SAS, and the prediction model was developed based on SPSS Modeler 18.0. 【Results】 1) There was a negative correlation between preoperative Hb and BMI and intraoperative blood transfusion rate, with Pearson correlation coefficient (R) as -0.168 and -0.046, respectively. The transfusion rate of patients under 1 year old was the highest, up to 15.63%. The transfusion rate of female patients was higher than that of male patients (P>0.05), as cardiac surgery rated at the highest 11.38%, but their per capita blood transfusion was lower than that of males (P<0.01). 2) The AUC range corresponding to the prediction model for transfusion probability was 0.67~0.88, and when the AUC reached the highest, the hit ratio, coverage rate and specificity of Model 9 was 10.7%, 85.76% and 75.4%, respectively. 3) The main factors contributing to the prediction model for transfusion volume in surgery were weight, Hb, total protein(TP), etc. 【Conclusion】 The prediction efficiency of the successfully constructed prediction model for perioperative blood use was better than that of MSBOS.