1.Significance of transrectal ultrasound combined with carcinoembryonic antigen examination on accurate preoperative staging of rectal carcinoma
Erguo PANG ; Che CHI ; Zhiwen YANG ; Bingzhao ZHANG
Cancer Research and Clinic 2011;23(11):765-767
Objective To study the consistency of preoperative staging by transrectal ultrasonography (TRUS) combined with serum carcinoembryonic antigen (CEA) and the postoperative pathological TNM staging (PTNM).Methods 118 rectal cancer patients pathologically proven were divided into preoperative TRUS combined with CEA group (59 cases) and along TRUS group (59 cases).The consistency of preoperative stag in 2 groups and postoperative pathological stage was analyzed retrospectively.Results In TRUS combined with CEA group,the accuracy of T stage was 79.7 % (47/59),and the accuracy of N stage was 77.8 % (42/59),compared with the postoperative pTNM.While in along TRUS group,the accuracy of T stage was 86.4 % (51/59),and the accuracy of N stage was 57.7 % (30/59).The consistencies of T and N stage in TRUS combined with CEA group and postoperative pTNM were better (κ =0.685,P =0.000; κ =0.544,P =0.000).While the consistency of T stage in along TRUS and postoperative pTNM was better (κ =0.755,P =0.000),but that of N stage was poor (κ =0.154,P =0.229).Conclusion Preoperative evaluation by the TRUS combined with CEA can increase the accuracy of preoperative stage which can provide more reliable basis for decision-making and improve the rate of coincidence of operative procedures in line with forecasts.At the same time,it can provide the basis for the accurate preoperative diagnosis and individualized treatment.
2.Modeling hepatoblastoma development with human fetal liver organoids reveals YAP1 activation is sufficient for tumorigenesis.
Li YANG ; Jin CHEN ; Jianqing LIANG ; Yufeng ZHANG ; Qingzhe WANG ; Xiaojun REN ; Jinsong WEI ; Qianchun GONG ; Jiting ZHANG ; Ning JIANG ; Xinhua LIN ; Jin LI ; Bing ZHAO
Protein & Cell 2022;13(9):683-688
3.Recapitulation of SARS-CoV-2 infection and cholangiocyte damage with human liver ductal organoids.
Bing ZHAO ; Chao NI ; Ran GAO ; Yuyan WANG ; Li YANG ; Jinsong WEI ; Ting LV ; Jianqing LIANG ; Qisheng ZHANG ; Wei XU ; Youhua XIE ; Xiaoyue WANG ; Zhenghong YUAN ; Junbo LIANG ; Rong ZHANG ; Xinhua LIN
Protein & Cell 2020;11(10):771-775
Betacoronavirus
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isolation & purification
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pathogenicity
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Bile Acids and Salts
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metabolism
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Bile Ducts, Intrahepatic
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pathology
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virology
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Cell Culture Techniques
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Coronavirus Infections
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complications
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pathology
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Cytokine Release Syndrome
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etiology
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physiopathology
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Cytopathogenic Effect, Viral
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Epithelial Cells
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enzymology
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pathology
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virology
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Humans
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Hyperbilirubinemia
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etiology
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Liver
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pathology
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Organoids
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pathology
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virology
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Pandemics
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Peptidyl-Dipeptidase A
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analysis
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Pneumonia, Viral
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complications
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pathology
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Receptors, Virus
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analysis
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Serine Endopeptidases
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analysis
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Viral Load