Objective To study the cognitive disorder in acute brain infarction. MethodCognition was meaured by P300 Peak Latency and The MMSE Scale for 32 patients with acute brain infarction. Results There are significant difference in P300 Peak Latency and The MMSE Scale scores between the patients and controls. ConclusionP300 Peak Latency could indicate the cognitive disorder in patients with acute brain infarction.

Objective To observe endothelial cells secreting and expressing nitric oxide by using red laser irradiation ( RLI) on cultured endothelial cells. Methods Cultured endothelial cells were irradiated with a red laser for 10, 20, and 30 minutes, respectively, and the concentration of nitric oxide in the cell supernatant was measured after 15 min,30 min.1 h,3 h and 6 h. In addition, the expression of inducible nitric oxide synthetase (iNOS) and endotlielial nitric oxide synthetase (eNOS) was measured through immunohistochemical staining. Results Compared with that in the control group, the expression of eNOS by the endothelial cells and the concentration of NO were stimulated by 2 mW RLI for 10 min, 20 min and 30 min, and reached a peak at 1 h, then declined gradually. The expression of iNOS, however, showed no significant difference. Conclusion RLI can increase NO concentrations in endothelial cells by stimulating the expression of eNOS rather than iNOS.

Objective To evaluate the effect of early rehabilitation and acupuncture on acute stroke. Methods125 cases stroke patients were divided into 4 groups: the early rehabilitation and acupuncture group, 34 cases(Group A); the early rehabilitation group, 39 cases(Group B); the early acupuncture group, 21 cases(Group C); and the control group, 31 cases. Bobath therapy and acupuncture were used. The CNS Damage Scale, Fugl Meyer Assessment(FMA), Modified Barthel Index(MBI), Clinical Therapeutic Effectiveness and Rehabilitation Efficiency were observed in all patients at the beginning, middle and end of the course. Results Rehabilitation Efficiency was the highest in Group A among all groups, and higher in Group B than in Group C and the control group, and higher in Group C than in the control group. The Clinical Therapeutic Effectiveness was better in Group A,B and C than in the control group, and better in Group C than in the control group. Conclusion It is a main and effective therapy to improve the patient\'s condition that early rehabilitation is combined with early acupuncture on acute stroke patients.

PURPOSE: The -1237T/C polymorphism of the Toll-like receptor 9 (TLR9) gene has been implicated in the susceptibility of inflammatory bowel diseases (IBDs), but the results remain conflicting. We further investigated this association via meta-analysis. MATERIALS AND METHODS: Multiple electronic databases were extensively searched until February, 2015. The strength of association was evaluated by calculating the pooled odds ratios (ORs) and 95% confidence intervals (CIs). RESULTS: A total of 2987 cases and 2388 controls from eight studies were analyzed. Overall, association was found between TLR9 -1237T/C polymorphism and the risk of IBDs when all the studies were pooled (recessive model, OR: 1.59, 95% CI: 1.02-2.47, p=0.04; homozygote comparison, OR: 1.62, 95% CI: 1.04-2.52, p=0.03; allele model, OR: 1.13, 95% CI: 1.00-1.27, p=0.05). Stratification by ethnicity indicated an association between TLR9 -1237T/C polymorphism and IBDs risk in Caucasians (recessive model, OR: 1.59, 95% CI: 1.02-2.47, p=0.04; homozygote comparison, OR: 1.62, 95% CI: 1.04-2.52, p=0.03; allele model, OR: 1.12, 95% CI: 1.00-1.27, p=0.05). When stratified by disease type, significant correlation were only found in the Crohn's disease subgroup (recessive model, OR: 1.69, 95% CI: 1.05-2.73, p=0.03; homozygote model, OR: 1.74, 95% CI: 1.07-2.82, p=0.02; allele model, OR: 1.15, 95% CI: 1.01-1.32, p=0.04). CONCLUSION: The present study suggested that the TLR9 -1237T/C polymorphism might act as a risk factor in the development of IBDs, particularly in Caucasians.
Alleles ; European Continental Ancestry Group/genetics ; Genetic Predisposition to Disease/*genetics ; Homozygote ; Humans ; Inflammatory Bowel Diseases/ethnology/*genetics ; Odds Ratio ; Polymorphism, Genetic/*genetics ; Risk Factors ; Toll-Like Receptor 9/*genetics/metabolism