1.Changes of Membrane Fluidity and Insulin Receptor of Erythrocytes in Parkinson Disease
Cheng HE ; Xiaoping PAN ; Zhihong LU ; Binghai ZHANG ; Deling WANG ; Yonglin WU ; Weiren ZHANG
Academic Journal of Second Military Medical University 1981;0(03):-
The membrane microviscosity and insulin receptor of erythrocytes were determined by fluorescence polarization analysis and insulin radioligand binding assay simultaneously. The patients with Parkinson disease (PD) had increased membrane microviscosity (P
2.Research progress of long non-coding RNA in non-small cell lung cancer
Xiao ZHAO ; Binghai ZHANG ; Xiaoxia LI ; Weilin YANG ; Guoyan ZHA ; Yin SUN ; Lijuan FU ; Rui YANG ; Tingting GONG ; Yan GUO
International Journal of Biomedical Engineering 2021;44(1):60-64
Lung cancer is currently one of the most common malignant tumors in the world. The occurrence and development of lung cancer, especially non-small cell lung cancer (NSCLC), are closely related to the abnormal expression of long non-coding RNA (lncRNA). lncRNA with a transcript of more than 200 nucleotides is involved in chromatin modification, transcription activation, transcription interference and other regulatory processes, and has varying degrees of regulation on the proliferation, migration, and invasion of tumor cells. It is characterized by up-regulation or down-regulation of expression. At present, there are a large number of studies on lncRNA, because lncRNA has considerable application prospects in the diagnosis, clinical treatment, drug resistance research and prognosis evaluation of NSCLC. In this paper, the overview of lncRNA, the up-regulation or down-regulation of NSCLC-related lncRNA expression, NSCLC clinical treatment and drug-resistant lncRNA were summarized.