1.Application of decitabine in the treatment of hematological malignancies
Cancer Research and Clinic 2013;(2):136-138
Decitabine is a methylation inhibitor,which is different from traditional chemotherapy drugs,with new and unique mechanism of action,and represent a new therapeutic concept.Methylation present in almost all cells,by inhibiting DNA methyltransferase,causing hypomethylation of DNA and cell differentiation or apoptosis to anti-tumor effect.In this paper,methylation inhibitor decitabine treatment of hematological malignancies in the application are reviewed.
2.Thoughts on the Objective and Orientation of Talent-cultivation of Independent Institute
Chinese Journal of Medical Education Research 2005;0(06):-
Independent institute is a new-rising education mode.With the steady development of independent institute,it is vital to uphold teaching-centered principle,define reasonable education objectives,deepen teaching reform,and innovate teaching management mechanism so as to guarantee its education quality and demonstrate its characteristics.
3.Application of Floating Duct in Dilation of Eustachian Tube
Journal of Audiology and Speech Pathology 1998;0(03):-
Stricture and insufficiency of eustachian tube in 43 cases were treated by floating duct for dilation of eustachian tube under fiber endoscopy. Clinical observation lasbed 2-10 months. 23 cases were significantly effective, 13 cases effective. No intraoperative complications.
4.Application of Computer Assistant Expert System in Biology Identification
Chinese Journal of Parasitology and Parasitic Diseases 2006;0(S1):-
The appliance status of computer assistant technology in biological identification was summarized and compared.The author considered that at the present time,the technology of expert system was relatively advanced.The technology of expert system was presented in detail.The status and foreground of the application of expert system in parasites identification was also generally expatiated.
5.Steadily promoting the technical research and the clinical application of interventional radiology for cervical spine
Journal of Interventional Radiology 1994;0(02):-
Many interventional procedures have been practiced in the treatment of cervical spine diseases for recent years. There are percutaneous biopsy, periradicular therapy for cervical never pain, percutaneous vertebroplasty and many kinds of intervertebral disc decompression. However, because of the manipulation difficulties and high risks of these procedures the popularization of interventional techniques in treating cervical spine disorders has actually been beset with difficulties. The main risks caused by interventional operation are puncture injuries and side-effect of therapeutic design. Therefore, how to reduce the procedure’s risk is a great challenge to interventional radiologists as well as an urgent research task.
6.Promoting interventional radiology in clinical practice of emergency medicine
Journal of Interventional Radiology 2001;0(06):-
Interventional radiology has lot of advantages in dealing with various emergencies. The technique is minimally-invasive,highly-effective and immediately-efficient,moreover,it integrates the diagnosis with the therapy perfectly. Besides,the interventional techniques applied in emergency medicine include not only the vascular interventions,such as embolization,embolectomy,etc,but also the nonvascular interventions,such as tracheal stent implantation,percutaneous vertebroplasty and so forth. However,importance has not been attached to the clinical use of interventional therapy in emergency medicine so far. It is imperative for us to promote the acceptance of interventional therapy in emergency medicine as well as to popularize the technique in clinical practice.
7.Research progress about molecular mechanism of CYP3A
Bing ZHU ; Honghao ZHOU ;
Chinese Pharmacological Bulletin 1986;0(06):-
CYP3A plays central roles in the oxidative and reductive metabolism of a variety of enogenous as well as exogenous compounds, it is very important to study about regulation of CYP3A geneexpression. This article reviews the recent development of molecular mechanism of regulation of CYP3A gene expression and CYP3A mutation. The relationships between CYP3A mutant and some diseases are also introduced.