Objective The aim of this study was to examine hope level in patients with coronary heart disease after per-cutaneous coronary intervention and explore correlation with illness perception.Methods 176 patients in outpatient department were recruited after per-cutaneous coronary intervention.The Herth Hope Index (HHI),Illness perception Questionnaire-Revised and demographic and clinical characteristics were collected.Results The hope level score of patients after per-cutaneous coronary intervention was (36.18±3.21),the hope level was correlated with seven dimensions of illness perception and was influenced by degree of education,income level,whether the disease is acute or chronic and control belief.Conclusions The patients after per-cutaneous coronary intervention show high level of hope and is affected by many factors,this provides the basis for taking effective measures to improve the patients' level of hope.

Objective To explore the treatment of irritable bowel syndrome, massage combined with microecological modulator therapy. Methods For 40 cases of irritable bowel syndrome patients using micro ecological regulator treatment, and classified as the control group, the other 40 patients used massage combined with microecological regulating agent treatment, and to the observation group, two groups of patients were in our hospital from March 2015 to January 2017. Results No significant difference between the two groups of patients in the treatment of the bacteria, after the number of packet treatmentintestinal aureus two groups had no significant difference, other bacteria were the observation group of patients obviously improved, improved the difference was significant(P<0.05). The total effective rate in observation group was 97.5%, only 75% of the control group, the observation group were significantly higher. Conclusion The clinical study of massage combined with microecological preparation in treatment of irritable bowel syndrome, the treatment is simple compared to micro ecological regulator, has certain advantages, can improve clinical symptoms of patients. At the same time, improve the therapeutic effect, so it is worthy of clinical use of priority.

Objective To determine the nature of enlarged mediastinal lymph nodes,the study of CT-guided transbronchial needle aspiration biopsy(CT-TBNA) was conducted. Methods According to classification and locating standard of mediastinal lymph nodes,CT-TBNA was performed in 158 mediastinal lymph nodes of 73 patients,including 54 primary lung cancer with enlarged mediastinal lymph nodes,5 malignant lymphoma, 3 mediastinal abscess and 11 mediastinal inflammatory adenopathy. Results CT confirmed that the needles were inside all 158 lymph nodes. Adequate aspirates for histologic and/or cytologic diagnosis were obtained in 136 of 158 (86%) lymph node biopsies. No serious complications occurred. Conclusion Locating standard of CT-guided TBNA was reliable. Puncture was safe and cost-effective.CT-TBNA was important for ascertaining the nature of mediastinal adenopathy and staging of neoplasms.

Epilepsy is a group of chronic diseases characterized by recurrent and transient brain dysfunction induced by abrupt and intermittent abnormal discharge of neurons in the brain, which is difficult to be cured. Thee auricular concha are is he zone of visera in TCM auricular points, but also the innervating area of the auricular brach of the vagus nerve. Auricular acupuncture, as a special treatment, has superior therapeutic effect for epilepsy. In recent years, remarkable progress has been made in the theoretical basis and clinic application of auricular acupuncture for epilepsy, and the ear-vagus percutaneous electrical stimulation apparatus (auricular acupuncture apparatus) is developed for clinical trial researches. From the basic study to clinical research of auricular acupuncture for epilepsy, the epilepsy pathogenesis as well as the intervention pathway and clinical efficacy of auricular: experimental support and rich clinical experience for auricular acupuncture apparatus.
Acupuncture Points ; Acupuncture, Ear ; instrumentation ; methods ; Ear ; innervation ; Epilepsy ; therapy ; Humans

BACKGROUND: Vascular dementia is a syndrome characterized by cognitive impairment, which is induced by ischemic or hemorrhagic apoplexy or ischemic-anoxic brain injury. It is assigned to "imbecility", "dementia", "sluggish consciousness", "susceptible to forget things" etc. By traditional Chinese medicine. Impairments of memory and cognition etc. Caused by dementia seriously affect psychosomatic health and quality of life of elderly people.OBJECTIVE: To observe the effects of shuanggen cephalocathartic decoctum on learning, memory and spatial discrimination ability of vascular dementia rats.DESIGN: Randomized control trail taking experimental animals as objects.SETTING: Teaching and Research Section of Basic Theory of Traditional Chinese Medicine, Preclinical Medicine College, Nanjing University of Traditional Chinese Medicine.MATERIALS: The experiment was performed in Laboratory of Viscerastate of Teaching and Research Section of Basic Theory of Traditional Chinese Medicine, Preclinical Medicine College, Nanjing University of Traditional Chinese Medicine, from January to February 2004. A total of 40 male SD rats were selected and randomly divided into sham operation group, model group, model plus traditional Chinese medicine group and model plus Western medicine group, with 10 in each group. Before the experiment, all the rats were adaptively fed for one week, free drinking and eating before and during the experiment. Medicine and reagent are shuanggen cephalocathartic decoctum and Nimotop tablet, and main experimental apparatuses are DTT-2 jumping apparatus and SMG-2 water maze apparatus.METHODS: Blood was collected from left ventricle under aseptic condi tion, and dried in incubator at 37 ℃, after trituration, it was sifted with sieve of 200μm meshes and embolus was prepared. 1 mg embolus and 0.3 mL physiological saline was mixed and shaken up into suspension. Common carotid artery was temporarily occluded with a vascular clamp, and external carotid artery was retrogradely intubated and the embolus suspension was injected into encephalon to establish model of multiple cerebral infarction. In sham operation group, canulate tubule was intubated only to the bifurcation of common carotid artery, with no fluid injected in. Before the experiment, rats in model group and sham operation group were normally fed, while rats in model plus traditional Chinese medicine group were additionally given shuanggen cephalocathartic decoctum [4 g/(kg·d)] infusion and rats in model plus western medicine group were additionally given Nimotop [2 mg/(kg·d)] infusion, once a day for consecutive 15 days. Passive escape jumping experiment was conducted on rats in each group on the 9th day.Recorded the reaction time for rat jumping onto the rubber cushion after electric shock and the frequency of mistakes of suffering electric shock due to jumping down from the platform in 3 minutes, and took the results as learning indexes. The test was repeated on the 10th day. Put the rat into the box for 3-minture adaptation, then put it on the rubber cushion; recorded the latency for rat first jumping down from the rubber cushion and the frequency of jumpingdown from the rubber cushion in 3 minutes, and took the results as memory indexes. Water maze spatial discrimination experiment was conducted on rats in each group on the 11th day, recorded the frequency of mistakes of rats entering dead end and the latency for landing on safe platform. Every time, took a 40-second rest after swimming. Each rat was trained 10 times a day for consecutive three days. MAIN OUTCOME MEASURES: Results of passive escape jumping experiment and water maze spatial discrimination experiment. RESULTS: Each group had a rat dead in the process of operation except sham operation group in which all rats moved normally. Totally 37 rats entered results analysis. ① Results of passive escape jumping experiment: On the 9th day, compared with model group, the reaction time of rats in sham operation group, model plus traditional Chinese medicine group and model plus western medicine group significantly shortened (P < 0.01 -0.05), the frequency of mistakes in 3 minutes remarkably decreased in sham operation group and model plus traditional Chinese medicine group (P < 0.05); on the 10th day, the latency was significantly prolonged in sham operation group as compared with model group (P < 0.05); compared with model group, the frequency of mistakes in 3 minutes significantly decreased in sham operation group, model plus traditional Chinese medicine group and model plus western medicine group (P < 0.05). ② Results of water maze spatial discrimination: On the 3rd day, compared with model group, the frequency of mistakes of rats entering dead end significantly decreased in sham operation group, model plus traditional Chinese medicine group and model plus western medicine group (P < 0.001-0.05); the frequency of mistakes in model plus traditional Chinese medicine group obvi ously decreased as compared with model plus western medicine group (P < 0.05). During the 2nd and 3rd days of water maze experiment, the time for the rat reaching terminal was significantly shortened in sham operation group, model plus traditional Chinese medicine group and model plus western medicine group as compared with model group (P < 0.05).CONCLUSION: Shuanggen cephalocathartic decoctum can significantly improve learning and memory ability of rat model of vascular dementia, and is more effective than Nimotop in the aspect of improving spatial discrimination ability of rat.

Communicable Diseases ; therapy ; Drugs, Chinese Herbal ; therapeutic use ; Humans ; Medicine, Chinese Traditional ; Phytotherapy ; Social Planning

Academies and Institutes ; Carcinoma in Situ ; diagnosis ; immunology ; Evaluation Studies as Topic ; Humans ; Immunohistochemistry ; methods ; standards ; Internationality

The transcutaneous auricular vagus nerve stimulation (taVNS) was researched and developed based on traditional Chinese medicine (TCM) auricular acupuncture (AA),vagus nerve stimulation (VNS) and anatomy.It is a typical representative of TCM modernization.Meanwhile,taVNS does not require surgery,with low cost,and has almost no side effects.Most importantly,it ensures a comparable efficiency as the classic VNS.The taVNS regulates the autonomic neural function as its core,opens up a new principle of peripheral nerve-brain network-body function,and has made breakthroughs in the treatment of epilepsy and depression.Other indications of taVNS contain disorders of consciousness (DOC),autism spectrum disorder (ASD),Alzheimer's disease (AD),and etc.The further improvement of taVNS technique will definitely benefit a wider range of patients.

Objective To explore the clinical efficacy of Wenshen Juanbi Deco ction combined with warm acupuncture in the treatment of cold and dampness lumbar disc herniation. Methods Retrospective analysis of our hospital in April 2015 to February 2017 treatment of 60 cases of cold and humid lumbar disc herniation in patients with clinical data, according to different treatment methods were divided into control group and the study group,with 30 cases in each group.The control group underwent routine single Pelvic traction treatment, the study group underwent Wenshen Juanbi decoction combined with warm acupuncture treatment, The symptom improvement after treatment in two groups was compared. Results The total effective rate was 86.67% (26/30) in the study group and 58.06% (18/30) in the control group. The difference between the two groups was statistically significant (P<0.05). Compared with before treatment, the index of lower and lower extremity radiating pain, straight leg raising test, lower limb skin sensation, tendon reflex, spinous process tenderness and limited waist activity after treatment in the two groups were significantly improved (P<0.05). And the improvement effect of the study group was better than that of the control group (P<0.05). Conclusion Wenshen Juanbi Decoction combined with warm acupuncture is effective in the treatment of cold and dampness lumbar disc herniation, which can effectively improve the clinical curative effect and improve the clinical symptoms of patients with high clinical application and popularization value.

Objective To appraise the clinical therapeutic effects of lamivudine in patients with chronic hepatitis B, and the recurrence of the disease after withdrawal of the drug. Method 122 patients with chronic hepatitis B treated with lamivudine were followed-up for over half a year after withdrawal. Result It was shown that, among the 9 cases in immunological tolerance stage and received lamivudine treatment, 4 showed effective result and ineffective in 5. All the 4 patients with effective result recurred within 6 months after lamivudine withdrawal. Among the 113 patients in non-immunological tolerance, 13 showed notable effective result (11.50%), 90 effective (79.65%) and 10 showed ineffective result (8.85%), respectively. The disease in 11 patients showing effective result recurred during the treatment. The rate of recurrence was 53.85% and 87.34% respectively in patients with notable effective and effective results. The level of ALT before lamivudine treatment showed no significant difference between the patients with abrupt and gradual withdrawal of lamivudine treatment, but it was significantly different after lamivudine withdrawal. The rate of recurrence showed no significant difference between patients with abrupt and gradual withdrawal of the drug. Conclusion The therapeutic effect of lamivudine is poor in immunological tolerant patients. Patients with chronic hepatitis B are likely to recur after lamivudine withdrawal. Lamivudine should be given for a long-term to inhibit persistent HBVDNA replication.