Proliferative diabetic retinopathy (PDR) is one of the serious ocular complications of patients with diabetes mellitus and also the leading cause of blindness.Pars plana vitrectomy (PPV) is an effective treatment for severe vitreous hemorrhage and PDR.The intraocular concentration of vascular endothelial growth factor (VEGF) of patients with PDR usually increase abnormally,which promote growth of neovessels and make it early to leak and bleed.Numerous neovessels in vitreous cavity and retinal surface can lead to intraoperative bleeding and may affect the definition and precision of operation and prolong surgical time.If we conduct gas/fluid exchange regardless of severe active bleeding,proliferate membrane may reoccur at a high rate postoperatively due to the residual platelet and impair the success rate of surgery seriously.In addition,with the high activity of neovessels,anterior chamber,vitreous and retinal hemorrhage may appear as well as other postoperative complications like postoperative high intraocular pressure caused by inflammation or hemorrhage and traction retinal detachment because of reoccurrence of fibro membrane,which directly affect the postoperative visual function recovery and long-term prognosis.As wide clinical application of anti-VEGF agents in recent years,studies found that preoperative intravitreal injection of anti-VEGF drugs assisted PPV can limit the activity of neovessels and significantly reduce the incidence of intraoperative and postoperative bleeding,facilitate operation,shorten surgical time and improve the success rate of surgery.In this paper,the mechanism,effectiveness,clinical utility and safety of anti-VEGF therapy assisted vitrectomy for the treatment of PDR are reviewed.

Objective To investigate the efficacy of rabeprazole combined with mosapride in the treatment of reflux esophagitis. Methods A total of 92 patients with reflux esophagitis admitted from April 2016 to April 2017 in our hospital were divided into study group and routine group (n = 46). The routine group was treated with omeprazole and Mosapride,the study group was treated with rabeprazole and mosapride. The clinical efficacy and adverse reactions in the two groups were observed and compared. Results The total effective rate was 91.30％ in the study group and 76.09％ in the conventional group, the difference was statistically significant (P<0.05). The total effective rate of reflux symptoms, esophageal irritation and esophageal irritation was significantly higher in the study group than in the conventional group (P<0.05)The adverse reaction rate was 4.35％ in the study group and 6.52％ in the conventional group, the difference was not statistically significant (P<0.05). Conclusion In the course of clinical treatment of reflux esophagitis, attention should be paid to the two aspects of acid suppression and gastric motility. In the inhibition of acid, the effect of Bella is obviously higher than that of omeprazole. In gastric motility, mosapride in clinical effect is better. Reflux esophagitis by rabeprazole combined with mosapride treatment, clinical efficacy is significant, and adverse reaction rate is low, safe and reliable, worthy of clinical application.

The breast cancer stem cells are a subpopulatiom of breast tumor cells that selectively possess tumor initiation and self-renewal capacity. Recent findings suggest that it may correlate with the failure treatment and relapse of breast cancer. The isolation of phenotypically distinct tumorigenic of breast cancers will find a way to elucidation of the pathways that account for their tumorigenic potential to cure the disease.

Objective:To observe the changes of structure and function of pharyngeal muscle in SD rats with altitude hypoxia induced obstructive sleep apnea syndrome(OSAS),in an attempt to investigate the remodeling of pharyngeal space and the possible biomechanical mechanism of OSAS.Methods:Twenty-four SD rats(12 male and 12 female) were randomly assigned to 4 groups with 6 rats in each group.Rats in group A and B were male and those in group C and D were female.Rats in group A and C were placed in altitude chamber and treated with altitude hypoxia 6 h per day for 22 days.The pressure in the chamber was 53.9 kPa with an oxygen concentration of 10.0%-11.2%.Rats in group B and D,serving as controls,received no treatment.All rats were sacrificed on the 23~(rd)day.The open-angle and the inside diameter of rats′ pharyngeal-ring and the pathology of pharyngeal tissues were examined in all rats.Results: The open-angles of rats′ pharyngeal-ring of group A, B,C and D were(55?24)?,(15?8)?,(38?20)?,and(35?15)?,respectively;and the inside diameters of the pharyngeal-ring(cm) were(0.4?0.2,) 0.2?0.1,0.3?0.1,and 0.3?0.1,respectively.The open-angle and the inside diameter of rats′ pharyngeal-ring in group A were significantly higher(P

With artificial intelligence,the authors designed an Expert System for the Differential Diagnosis and Treatment of Lumbago.ESSDTL shows that it not only helps doctors to diagnose the illness of lumbago but also helps young doctors and medical students to gain experience by running practical cases and explaining their procedures for diagnosing and treting the diseases through ESDDTLexplanation facilities.

Acetyltransferases ; genetics ; Breast Neoplasms ; genetics ; Female ; GPI-Linked Proteins ; Gene Expression Regulation, Neoplastic ; genetics ; Humans ; Membrane Glycoproteins ; genetics ; Neoplasm Metastasis ; genetics ; physiopathology ; S100 Proteins ; genetics ; Transcription Factors ; genetics

Foreign Bodies ; surgery ; Head ; Humans ; Imaging, Three-Dimensional ; Jaw Fractures ; surgery ; Maxillofacial Injuries ; diagnostic imaging ; surgery ; Radiography, Dental, Digital ; Surgery, Computer-Assisted ; Tomography, X-Ray Computed

The important meaning of the construction of an economical-type mode of health economy management is expounded, and the measure and principle of it should be taken and followed. This management mode can relieve the social problem of "high expense and difficulties in medieine.

Due to the high incidence and mortality of digestive system malignant tumor,so it is of great significance to make further research for digestive tract tumor.Platinum drugs,one of the traditional drugs which is used for the chemotherapy for digestive system tumor,which has been extensively applied to the chemotherapy for malignant tumor.However,the resistance to the drugs exerts a serious influence on its curative effect.At present,it is believed that the nucleotide excision repair(NER)constitutes one of the most important mechanisms which results in the resistance to platinum drugs,mainly because it causes the twisting of DNA helix by removing large numbers of platinum compounds.The nucleotide excision repair cross complementation group 1(ERCC1)plays an important role in the process of NER.The different expression of ERCC1 in peripheral blood and tumor tissue of patients with digestive sysem tumor has a close connection with therapeutic effect of the platinum-containing chemotherapy.This article aims to provide an overview of the relation between the ERCC1 research development and the curative effect of cisplatin chemotherapy for digestive system tumor.

The synaptic organization of the sexually dimorphic nucleus of the preopticarea(SDN-POA)of male and female rats were examined with electron micro-scope.The results indicated that the synaptic pattern of SDN-POA showedsignificant sexual dimorphism:1.The numbers of total and shaft synapses whichoccupied the vast majority of total synapse were 2 times greater in male than infemale.2.The number of spine synapse of the female was 4.6 times greater thanthat of the male.3.In female,either the numbers of spine synapse with clear andmixed synaptic vesicles or the numbers of symmetrical and asymmetrical spinesynapses were markedly higher than in male.In contrast,the ratio of Gray Ⅱ toGray Ⅰ was 2.4 times larger in male than in female.4.The number of shaft synapsewith clear vesicle was greater in male than in female.In both sexes,however,thesignificant difference in the number of shaft synapse with mixed vesicle was notfound.5.There was no significant sexual difference in the number of asymmetricalshaft synapse,while the number of symmetrical shaft synapse was 2.7 times greaterin male than in female.