Objective To study the chemical constituents from alcohol extract and water extract in Lepidozia vitrea in order to find out their bioactive compounds.Methods The chemical constituents were isolated by various column chromatographic methods and the structures of the compounds were elucidated by spectral analysis.Results Six compounds were obtained and their structures were identified as phytol (Ⅰ),7-hydroxycalamenene(Ⅱ),daphnetin(Ⅲ),and daucosterol(Ⅳ) from the alcohol extract,D-glycero-D-galacto-heptitol(Ⅴ) and D-erythro-L-galacto-octitol(Ⅵ) from the water extract.Conclusion Compounds Ⅰ-Ⅵ are isolated from this plant for the first time.

ObjectiveTo analyze the impact of combined use of motherwort injection with oxytocin on hemorrhage in cesarean section and postoperative stage.Methods512 pregnant women after processing cesarean section were randomly divided into an experimental group (n=256) and a control group (n=256).The experimental group used motherwort injection and oxytocin,and the other group only used oxytocin.Intraoperative and postoperative bleeding and adverse drug reactions were observed.ResultsBleeding volume in the experimental group was less than the control group [ (210.43 ± 50.38)ml,(35.84 ±29.24)ml,(61.62 ±35.32) ml vs (234.14 ±16.91) ml,(52.37 ± 32.15) ml,(86.18 ± 36.67) ml],P＜0.05).There were no significant adverse reactions.ConclusionMotherwort injection and oxytocin used together can be more effective in reducing bleeding in cesarean section and postoperative stage.

Objective To study the diagnosis and treatment of restless legs syndrome(RLS)in the elderly.Methods The diagnosis of RLS was based on criteria proposed by the International Restless Legs Syndrome Study Group.Ten elderly patients with RLS were enrolled in the research. The clinical presentation and treatment results were analyzed retrospectively.Results All 10 patients were complained of compelling urge to move their limbs.The sensory symptoms were involved in the 4 patients' legs,involved both arms and legs in another 5 patients.It occurred unilaterally in the left of I patient.All patients complained of syndromes aggravated in the night, other three patients also had distinct syndromes in the daytime.Three patients had family history of RLS.The unpleasant sensations were partially or totally relieved by movement.Neurophysiological tests in 5 patients were normal.The iron deficiency occurred only in 1 patient with low serum ferritin and iron levels,Rebound and augmentation were observed in 1 patient in the course of three years treatment with Sinemet.All patients administered a dopamine receptor agonist(pergolide)and showed positive results.Oral administration of iron improved RLS symptoms in a patient with iron deficiency. Conclusions The diagnosis of RLS is usually based on the patient's clinical presentation,which has characteristic feature in the elderly.Rebound and augmentation are serious side-effects in the course of long-term treating with L-DOPA.Therapy of RLS with dopamine receptor agonists is firstly chosen.

Objective: To evaluate the effect of recombinant factor VIIa (rFVIIa) on the early recovery of patients undergoing cardiac valve replacement (CVR) under cardiopulmonary bypass (CPB). Methods: Twenty-two patients receiving CVR under CPB were randomized into rFVIIa (40 μg/kg) and placebo group. Patients in rFVIIa group received 40 μg/kg rFVIIa after protamine reversal of heparin and those in placebo group received placepo. Blood samples were collected before operation, after intra-operation heparinization, before protamine reversal of heparin, before and 15 min, 45 min, 2 h, 24 h, 120 h after application of rFVIIa for blood routine and coagulation analysis. Blood samples were also collected from the placebo group at the same time points. The postoperation thoracic drainage, postoperation blood transfusion, period of mechanical ventilation, period of ICU stay, and hospitalization costs were recorded and compared among all patients. Results: Patients in rFVIIa group had satisfactory hemostasis outcomes and there were no thrombotic complications, cardiac ischemic events, or death. The prothrombin time (PT) was (14.1±3.0) s 15 min after the rFVIIa injection,(13.5±1.7) s after 45 min, and (11.6±1.2) s after 2 h, all with significant differences when compared to those of the corresponding 3 time points in placebo group (P<0.01). The international normalized ratio (INR) was 1.05±0.26 15 min after rFVIIa injection, 0.93±0.16 after 45 min, and 1.04±0.19 after 2 h, all with significant differences when compared to those of the corresponding 3 time points in placebo group (P<0.01). The thoracic drainage, blood transfusion, period of mechanical ventilation, and the period of ICU stay were obviously decreased in rFVIIa group compared with those in placebo group; the hospitalization costs were similar in the 2 groups. Conclusion: rFVIIa can effectively improve the coagulation function in patients receiving cardiac valve replacement under CPB and reduce the need for blood transfusion, without significant adverse effect.

AIM:To observe and analyze visual quality changes of the patients with posterior capsule opacification ( PCO ) Nd:YAG laser posterior capsular dissection, including the change of the best corrected vision acuity ( BCVA ) , total high- order aberration ( tHOA ) , and the modulation transfer function ( MTF) .
METHODS:In this prospective observational study, 100 cases of patients ( 100 eyes ) with posterior cataract underwent Nd:YAG laser posterior capsular dissection ( posterior capsular diameter dissected was 5mm or higher). The mean age was 65. 52±7. 01 years old. The change of the BCVA was collected. The tHOA and MTF under the 3mm and 5mm pupil diameter were assessed by iTrace respectively before and after Nd:YAG laser posterior capsular dissection.
RESULTS:All the surgery went well without obvious intraoperative and postoperative complications happened. The preoperative BCVA was 0. 451 ± 0. 023 while the postoperative BCVA was 0. 763±0. 025. The difference of BCVA before and after Nd: YAG laser surgery was statistically significant (P<0. 01). At 3mm pupil diameter, the tHOA preoperative was 0. 551 ± 0. 031 while the postoperative tHOA was 0. 214± 0. 011, the differences were significance (P<0. 05). At 3mm pupil diameter while the spatial frequencies ( 5cpd, 10cpd, 15cpd, 20cpd, 25cpd, 30cpd ) respectively, the MTF tHOA value postoperative (0. 644±0. 023, 0. 49±0. 011, 0. 311±0. 015, 0.202±0. 018, 0. 056±0. 027, 0. 041±0. 011) were significantly higher than that preoperative (0. 401±0. 021, 0. 261±0. 026, 0. 179±0. 012, 0. 108±0. 014, 0. 031±0. 016, 0. 022±0. 021), and the difference has statistical significance (P<0. 05). At 5mm pupil diameter, the tHOA preoperative was 0. 752±0.028 while the postoperative tHOA was 0. 361±0. 014, the differences were significance (P<0. 01). At 5mm pupil diameter while the spatial frequencies ( 5cpd, 10cpd, 15cpd, 20cpd, 25cpd, 30cpd) respectively the MTF tHOA value postoperative (0. 426±0. 027, 0. 209±0. 018, 0. 172±0. 013, 0. 116±0. 015, 0. 049±0. 010, 0. 034±0. 014 ) were significantly higher than that preoperative (0. 234±0. 021, 0. 102±0. 019, 0. 088±0. 016, 0. 058±0. 022, 0. 021±0. 014, 0.016 ± 0. 011 ), and the difference had statistical significance (P<0. 05).
CONCLUSION: Patients with posterior capsule opacification ( PCO ) Nd:YAG laser posterior capsular dissection can help improve BCVA, reduce tHOA, increase MTF tHOA values, and significantly improve visual quality of patients.

OBJECTIVE:To investigate the improvement effect of Prostatitis capsule on chronic non-bacterial prostatitis(CNP) model rats. METHODS:60 rats were randomly divided into sham operation group (distilled water),model group (distilled wa-ter),Pule'an tablet group(positive control,2 g/kg)and Prostatitis capsule high-dose,medium-dose,low-dose groups(16,8,4 g/kg). Except for sham operation group,other 5 groups were injected Xiaozhiling injection 0.2 mL to reduce CNP model. After 7 d of modeling,they received related medicines,ig,once a day,for 45 d. After 24 h of last administration,prostate lesions were ob-served by eyes and wet quality was weighed. White blood cell(WBC)count and lecithin body(SPL)count were conducted under microscope,and prostate tissue slices were pathologically observed. RESULTS:Compared with sham operation group,prostate showed gray nodules,adhesion in glands and surrounding tissue;wet quality of prostate and WBC,SPL count in prostate tissue were significantly increased(P<0.01);under microscope,there were significant congestion,edema and a variety of inflammatory cell infiltration in prostate interstitial. Compared with model group,gray nodules in prostate in Pule'an tablet group and Prostatitis capsule group were reduced,as well as adhesion degree in prostate and surrounding tissue;wet quality of prostate and WBC,SPL count in prostate tissue were significantly decreased(P<0.01);pathological changes had improved to varying degrees under micro-scope,especially the changes in Prostatitis capsule high-dose group,and prostate tissue only showed mild congestion,edema and little inflammatory cell infiltration. CONCLUSIONS:Prostatitis capsule has a certain improvement effect on CNP model rats.

OBJECTIVE:To establish the quality standard for Prostatitis capsules. METHODS:TLC method was performed to qualitatively identify Pseudostellaria heterophylla,Acortw tatarinowii,Sargentodoxa cuneata,Rubia cordifolia and Vaccaria segeta-lis in the preparation. HPLC method was adopted to determine the content of leonurine in the preparation. The determination was performed on Agilent Eclipse XDB-C18 column with mobile phase consisted of methanol-0.025 mol/L potassium dihydrogen phos-phate(pH adjusted to 2.5)(24 : 76,V/V)with phosphoric acidat the flow rate of 1.0 mL/min. The detection wavelength was set at 277 nm,and column temperature was 30 ℃. The sample size was 10 μL. RESULTS:The TLC spots of P. heterophylla,A. tatari-nowii,S. cuneate,R. cordifolia,and V. segetalis were clear and well-separated without interference from negative control. The lin-ear range of leonurine were 4.05-81.00 μg/mL(r=0.9999). RSDs of precision,stability and reproducibility tests were all lower than 2.0%. The recovery was 98.47%-103.83%(RSD=2.04%,n=9). CONCLUSIONS:Established standard can be used for quali-ty control of Prostatitis capsules.

Objective:To analyze the effects of SBAR(namely situation, background, assessment and recommendation) communication mode-guided scenario simulation exercise on the quality of shift change of practice nurses and the incidence of nursing risks.Methods:From May 2017 to December 2018, 46 nurses interning in the Department of Cardiovascular Medicine of Guangyuan Central Hospital were selected as the control group, and received practice guidance according to the conventional shift change mode; 46 nurses were selected as the research group having the SBAR communication mode-guided scenario simulation exercise from January 2019 to June 2020 in the same department. The evaluation results of the quality of nurses' shift change, the evaluation results of the quality of nurses' succession, and the satisfaction of nurses were compared between the two groups. SPSS 22.0 was used for t test and chi-square test. Results:The evaluation results of 7 items of nurses' handover quality in the research group were better than those in the control group ( P<0.001). The evaluation results of 6 items of nurses' succession quality in the research group were better than those in the control group ( P<0.001). The scores of 5 dimensions in the research group were higher than those in the control group ( P<0.001). Conclusion:The implementation of SBAR communication mode-guided scenario simulation exercise can improve the quality of nurses' shift change and the satisfaction of practice nurses.

This paper introduces the ideas and methods concerning the design of network-based curriculm of hepatobiliary surgery. Design of network-based curriculm should highlight independence of online learning,emphasize network-based resources to support learning.Net-work-based curriculm should emphasize the evaluation of learning effect.

ObjectiveTo investigate the effects of strengthening internal and external abdominal oblique muscles on sitting balance in stroke patients with hemiplegia. Methods60 cases of patients with hemiplegia were randomly divided into treatment group and control group, 30 cases in each group. Control group patients were treated with conventional treatment. Internal and external abdominal oblique muscles training were accepted in treatment group in addition. Before and 1 month after treatment, all the patients were assessed with Fugl-Meyer Assessment of balance function and muscle strength. ResultsAfter treatment, the Fugl-Meyer assessment scores of balance, muscle strength were significantly higher in the treatment group than in the control group（P＜0.01）. ConclusionMuscle strengthen training in internal and external abdominal oblique muscles will promote sitting balance in hemiplegic patients.