Objective To study the effect of Gaoyuankang capsule on the serum nitric oxide (NO) content and plasma atrial natriuretic peptide(ANP), calcitonin gene-related peptide(CGRP) and endothelin(ET) content in great numbers of entrants landing at high altitude rapidly and its significance. Methods 2150 new soldiers, who swiftly entered plateau by air from plain, were randomly divided into experimental group (EG,n=1150) and control group (CG,n=1000). EG continually orally took Gaoyuankang capsules for 3 days before boading a plane. CG orally took placebo. The changes of serum NO content and plasma ANP, CGRP and ET content before and after entering plateau, and the incidence of acute high altitude disease (AHAD) after entering plateau were compared between the two groups, each group containing 40 randomly selected soldiers. Results NO and CGRP concentration of CG remarkably decreased after entering plateau than before entering plateau, while ANP and ET levels remarkably increased after entering plateau than before entering plateau (P

Objective To explore the significance and effect of NO treatment on plasma ET, NPY, ANP and CGRP in acute high altitude diseases(AHAD) patients. Methods 47 AHAD patients were randomly divided into two groups, one group receiving routine medicine treatment (n=23), and the other group receiveing NO treatment (n=24). The level changes of serum NO, plasma ET, NPY, ANP and CGRP and clinical symptom score were compared before and after treatment in the two groups. Results The levels of plasma ET, NPY, ANP and CGRP, and clinical symptom score remarkably decreased after treatment in two groups, while serum NO and CGRP levels remarkably increased (P

ObjectiveTo explore the influence of Gaoyu ankang capsule on the water load of ent rants landing at high altitude rapidly and its significance. Methods 80 soldiers who went from plain to high altitude by air for the first time were randomly divided into, experi mental group and control g roup. Experimental group was asked to orally take 2 granules of Gaoyuankang capsule 3 times per day for 3 days before boarding a plane. Control group was not given any pharmaco-prevention. Water load experiment was performed at the fi rst day before and at the third day after landing at high altitude in the tw o groups. Urine quantity of two groups was recorded and compared at various time points in 150 minutes after water was given. Results Urine quantity at each time points in 61～150 minutes after water load experiment beginning and total urine quantity i n corresponding time points remarkably de creased in the control group after landing at high altitude(P

Objectives To analyze the relationship between the multi-organ hypoxia damage and the death of acute high altitude sickness severe case. Methods 3220 cases from 1956. 06 to 2005.06 in the hospital were reviewed by questionnaire and the cases in MODS or death were screened out. The cause of death and feature were analyzed by the data as clinical symptom, physical signs and auxiliary examination. Results 281 cases complicated by MODS (include 35 dead cases) were found out by review. The incidence with MODS is 8.73% , and the death rate was 1.09%. The masculine incidence rate of the clinical symptom, physical signs and auxiliary examination in death were 2. 86% ~65. 71% , 2. 86% ~ 100% and 14. 29% ~ 100% , respectively. The MODS incidence in dead cases was 100%. Compared with the curing group, the MODS number, cardiac functional disturbance, brain disorder and renal functional disturbance in the death group had a significantly high incidence rate in all the 281 cases with MODS( P <0.05). With dependability analysis, there were a significantly direct correlation relationship between the death in the severe cases with acute high altitude sickness and the number of MODS ( r = 0. 3473, P < 0.001). Conclusion Hypoxia to the damage of multi-organ function play an important role in death of the severe cases with acute high altitude sickness in high attitude area, and the functional disturbance of important organs as heart, brain and kidney is the most important cause to death.

Objective To observe the effect of the therapy using NO with plateau air balance on acute high altitude disease.Methods Forty-seven acute high altitude disease patients were selected and divided into two groups randomly: twenty-three cases as a routine drug treatment group which used the protocol of inhaling oxygen and the drugs including Aminophylline,DEX and Frusemide,while twenty-four cases as a NO treatment group which only used the protocol of inhaling 0.001% NO gas air balanced in plateau(altitude 3,658 m)twice daily,an hour each.Observe the two groups' clinical symptoms,physical signs and clinical symptom's scores before and after the three day treatment.Results The clinical symptoms,physical signs and clinical symptom's scores of the two groups after the three day treatment improved significantly.The effect of the NO treatment group was more significant(the drug group P

AIM: To evaluate the prophylactic effect of aminophylline on the pulmonary hypertension rebound reaction to exposure to NO in the hypoxic pigs. METHODS: The 10 pigs undergone Swan-Ganz catheter, the mPAP was measured with a Physio-recording instrument and PaO 2 was measured with a blood gas analyzer, when breathing NO for 30 minutes and suddenly stopping breathing NO, administing aminophylline 0.25 g, followed by 30 minutes with room air. The respiratory rate and heart rate were also monitorried with a Hewlett-Packard portable monitor. RESULTS: The mPAP of the acute hypoxic pig was induced significantly after breathing 10 -5 NO. When suddenly stopping breathing NO, the induced mPAP became more and more high, the level of the mPAP in 5 minutes was similar to the values before absorbing NO, the mPAP in 10 minutes was higher than values before absorbing NO, while the level of PaO 2 was lower than the values before absorbing NO; but suddenly stopping breathing NO, administing aminophylline, although the induced mPAP became high, the speed was slower than the controls, the level of the mPAP in 30 minutes still was lower than the values before absorbing NO. CONCLUSION: Aminophylline has preventive effects on the pulmonary hypertension rebound reaction to exposure to NO in the hypoxic pigs.

Electrolyte disturbance was prominent in patients with severe acute mountain sickness. In these patients hypoxia caused water and salt retension together with vasoactive substances and excessive free radicals might play important roles in the development of multiple organ dysfunction syndrome (MODS). More attention should be given to electrolyte monitoring in dealing with these severe mountain sickness in field.