Objective To determine the relationship between maternal negative major life events during the first trimester and incidence of congenital heart diseases(CHD) in their offspring.Methods The 4-2-1 medical information was referred and screen CHD children who were confirmed by Municipal hospitals over.A 1:2 case-control study was carried out with face-to-face structured interviews and telephone interviews to investigate parents of 116 children with CHD and 232 healthy matched children,including the parents′ demographic variables(such as whether the working environment exposure to toxic and hazardous substances 1 year before pregnancy,et al),mother′s experience of previous adverse pregnancy,duration of pregnancy condition(such as maternal negative major life events during the first trimester,the history of catching a cold or fever during the first trimester.The possible risk factors were analyzed by simple factors Logistic regression methods.Then,diagnosing the colinearity among these suspicious risk factors,and rejecting it if necessary.Finally,multiple factors conditional Logistic stepwise regression was used to filter once more.Results The results revealed that maternal negative major life events and taking medicine during the first trimester,mother′s experience of previous adverse pregnancy were related to the occurrence of CHD in the offspring.Moreover,maternal negative major life events during the first trimester play the most important role(OR=1.810).Conclusions Strengthening mothers′ mental health and controlling or reducing maternal negative major life events during the first trimester may be effective in reducing the risk of CHD.

Adolescent ; Adolescent Development ; Body Mass Index ; Humans ; Obesity ; Puberty

Adolescent ; Health Promotion ; Humans

Advanced in medical and surgical management have led to reduce mortality in children with congenital heart disease(CHD).However,more recent and ongoing research had been focused on neurodevelopmental outcome.With the improved survival in children follo-wing surgery for cardiac malformations,increased emphasis had being placed on neurological sequelae,especially on cognitive function.Car-diac surgery couldn't correct cognitive disorder,more and more findings suggested that the cognitive disorder of CHD might be the result of utero injury.J Appl Clin Pediatr,2009,24(1):61-64

Objective To evaluate the efficacy of radiofrequeney ablation on tachyrhythmia and cardiac acute injure.Methods Endomyocardin was signified and ablated using routine methods,the effects of radiofrequency ablation on cardiac autonomic nerve function,cardiac systolic function,radiofrequency electric injury and changes of troponin,SOD and endothelin level in pre-operation and post-operation were evaluated to study RFCA procedure caused cardiac acute injury.Results Thirty-eight patients with tachyarrhythmia underwant RFCA.The successful rate was 100%,and none had serious complications.Postoperative LF and HF were reduced significantly as compared with preoperation,Atrium and ventricle premature beats had no significant difference before and after RFCA.Cardiac systolic function had no significant changes before and after procedure,but troponin,SOD and endothelin levels were significantly higher in postoperation than those of preoperation.Conclusions RFCA is a principal therapy of tachyarrhythmia because its excellent therapeutic effect,less side effect and eradication,RFCA has acute cardiac injury,but the injury is slight.

Brain ; physiology ; Child ; Child Behavior ; physiology ; Child Development ; physiology ; Humans ; Infant ; Motor Activity ; physiology ; Motor Skills Disorders ; diagnosis

Adolescent ; Attention ; physiology ; Female ; Humans ; Male ; Obesity ; physiopathology ; psychology ; Weight Loss ; physiology

Aged ; Cardiac Pacing, Artificial ; Cardiac Resynchronization Therapy ; Female ; Heart Ventricles ; Humans

Objective To investigate and evaluate the pathological features and diagnostic significance of MSCT findings in scan postprocessing for focal nodular hyperplasia (FNH).Methods A total of 24 patients with FNH who underwent MSCT scan post processing were investigated.The FNH were pathologically and clinically confirmed.Results There are single focus in 22 cases and multiple focus in 2 cases.On plane scan 16 lesions were hypodensity and other 7 isodensity,4 hyperdensity( cases with fatty liver).After contrast,17 lesions were evenly high enhanced on arterial phase;13 lesions showed still hyperdensity and other 10 lesions isodensity,4 lesions hypodensity on parenchymatous phase.Only 5 lesions were hyperdensity but 9 lesions isodensity and 13 lesions hypodensity on delayed phase.Twelve lesions in 27 were detected with central stella-formed cicatrix.There were thickening tumor feeding arteries in 24 lesions,the artery of which were entered integrated into parenchymatous lesions with soft course.Conclusion Synthesizing the charcteristic appearance on MSCT scan postprocessing,doctor could make correct diagnosis and differentiated diagnosis for FNH.