Adolescent ; Adolescent Development ; Body Mass Index ; Humans ; Obesity ; Puberty

Objective To determine the relationship between maternal negative major life events during the first trimester and incidence of congenital heart diseases(CHD) in their offspring.Methods The 4-2-1 medical information was referred and screen CHD children who were confirmed by Municipal hospitals over.A 1:2 case-control study was carried out with face-to-face structured interviews and telephone interviews to investigate parents of 116 children with CHD and 232 healthy matched children,including the parents′ demographic variables(such as whether the working environment exposure to toxic and hazardous substances 1 year before pregnancy,et al),mother′s experience of previous adverse pregnancy,duration of pregnancy condition(such as maternal negative major life events during the first trimester,the history of catching a cold or fever during the first trimester.The possible risk factors were analyzed by simple factors Logistic regression methods.Then,diagnosing the colinearity among these suspicious risk factors,and rejecting it if necessary.Finally,multiple factors conditional Logistic stepwise regression was used to filter once more.Results The results revealed that maternal negative major life events and taking medicine during the first trimester,mother′s experience of previous adverse pregnancy were related to the occurrence of CHD in the offspring.Moreover,maternal negative major life events during the first trimester play the most important role(OR=1.810).Conclusions Strengthening mothers′ mental health and controlling or reducing maternal negative major life events during the first trimester may be effective in reducing the risk of CHD.

Adolescent ; Health Promotion ; Humans

Brain ; physiology ; Child ; Child Behavior ; physiology ; Child Development ; physiology ; Humans ; Infant ; Motor Activity ; physiology ; Motor Skills Disorders ; diagnosis

Objective To evaluate the efficacy of radiofrequeney ablation on tachyrhythmia and cardiac acute injure.Methods Endomyocardin was signified and ablated using routine methods,the effects of radiofrequency ablation on cardiac autonomic nerve function,cardiac systolic function,radiofrequency electric injury and changes of troponin,SOD and endothelin level in pre-operation and post-operation were evaluated to study RFCA procedure caused cardiac acute injury.Results Thirty-eight patients with tachyarrhythmia underwant RFCA.The successful rate was 100%,and none had serious complications.Postoperative LF and HF were reduced significantly as compared with preoperation,Atrium and ventricle premature beats had no significant difference before and after RFCA.Cardiac systolic function had no significant changes before and after procedure,but troponin,SOD and endothelin levels were significantly higher in postoperation than those of preoperation.Conclusions RFCA is a principal therapy of tachyarrhythmia because its excellent therapeutic effect,less side effect and eradication,RFCA has acute cardiac injury,but the injury is slight.

Adolescent ; Attention ; physiology ; Female ; Humans ; Male ; Obesity ; physiopathology ; psychology ; Weight Loss ; physiology

Advanced in medical and surgical management have led to reduce mortality in children with congenital heart disease(CHD).However,more recent and ongoing research had been focused on neurodevelopmental outcome.With the improved survival in children follo-wing surgery for cardiac malformations,increased emphasis had being placed on neurological sequelae,especially on cognitive function.Car-diac surgery couldn't correct cognitive disorder,more and more findings suggested that the cognitive disorder of CHD might be the result of utero injury.J Appl Clin Pediatr,2009,24(1):61-64

Aged ; Cardiac Pacing, Artificial ; Cardiac Resynchronization Therapy ; Female ; Heart Ventricles ; Humans

BACKGROUND: The study aimed to investigate the clinical characteristics of acute renal failure (ARF) caused by oral acyclovir. METHODS: A 45-year-old Chinese male patient with acyclovir-induced ARF suffered from abdominal pain for one day. The pain was extended to the epigastric area from the right lower quadrant. Transient oliguria was seen in addition to microscopic hematuria and proteinuria. The serum creatinine concentration was 304 μmol/L. Eight days before the occurrence of ARF, the patient took oral acyclovir for facial neuritis. RESULTS: His renal function was restored completely following the discontinuation of acyclovir, with continuous renal replacement therapy for 54 hours and some symptomatic treatment. CONCLUSION: The presentation of acute renal failure caused by acyclovir can be diverse, but the prognosis is good after active treatment.