Objective To retrospectively analyze the results of 52 cases with different diseases of alimentary tract treated by APC and evaluate its effectiveness and safety. Methods From April 2001 to May 2002, 52 cases with different digestive diseases were treated by APC under endoscopy , the disorders included 29 cases of GI bleeding (peptic ulcer 9, angiodysplasia 8, stoma bleeding 3, postpolypectomy bleeding 5 and flat crenated adenoma bleeding , duodenal angiodysplasia, multiple colon AVM and stoma bleeding of cardiac cancer, 1 in each) ,and 23 cases of polypoid lesion( esophagus and cardia polyps 5, flat esophageal lesion with dysplasia 1, Menetrier's disease 1, colon-rectal polyps 6, multiple polyps 5, and stump of giant sessile adenoma 4 and postoperative recurrence of cardia carcinoma 1). Results The theraputic results showed that only one GU case with artery spurting faild after APC therapy of bleeding ulcers, the hemostasis rate for all GI bleeding was 96. 5%. For the polyp smaller than 5mm in diameter, APC was the choice of treatment, but polypectomy with snare is suitable for bigger polyp or adenoma before APC for stump clearance, and the endocut (high-frequency e-lectron) was safe and effective for giant sessile adenomas, we had only one case with mucosa gas vacu-ole which had no clinical event. Conclusion APC has excellent effect of hemostasis on most non-porta-hypertensive GI bleeding except bigger artery spurting, and it combined with endocut is a safe and effective treatment of various polypoid lesions.