Objective: To explore the endothelial microparticle (EMP) level in elderly patients with acute coronary syndrome (ACS) combining diabetic mellitus (DM)) and to study the relationship between EMP level and ACS combining DM in elder patients.
Methods: A total of 208 patients≥65 years with coronary angiography in our hospital were summarized including 124 male with the age of (71.9 ± 5.2) years. The patients were divided into 3 groups, Control group, n=51 normal subjects, ACS without DM group, n=83 and ACS+DM group, n=74. Plasma EMP levels were measured by FACSCalibur lfow cytometry as CD31+/CD42b-EMPS and the vascular stenosis degree was quantitatively calculated with Gensini score.
Results: The CD31+/CD42b-EMPs level in ACS + DM group >ACS without DM group > Control group, all P<0.01. Compared with ACS without DM group, the ACS+DM group had more patients with multiple vascular lesions and less patients with single vascular lesions, all P<0.01. The Gensini score was positively related to CD31+/CD42b-EMP level in both ACS+DM group and ACS without DM group (r=0.637, P<0.01).
Conclusion: Plasma CD31+/CD42b-EMPs level increased in elderly ACS patients and the elevation level related to vascular lesion degree/combining with DM, which indicated the endothelial dysfunction in such patients.