Coenzyme Q (CoQ),also known as ubiquinone,is a lipid-soluble quinone compound which exists in biological organis ms widely.The numbers of side chain isoprene of different sources of coenzyme Q are different.Coenzyme Q in humans and mammals are called coenzyme Q10 (CoQ10 ,Q10 ), in that the ubiquinone side chain of humans and mammals are mainly composed of 10 isoprene units.In the mitochondrial respiratory chain,it acts as a mobile electron transporter and is a cofactor of uncoup-ling proteins,which is an essential endogenous substance in the process of cell respiration and metabo-lis m.Moreover,CoQ possesses independent antiapoptosis feature,which regulates the mitochondrial permeability transition pore.Mitochondrion is an important organelle,which is the place for energy stor-age and supply,providing the energy for vital movement.There are various kinds of chemical toxicants in the hu man environ ment,and they can enter into the hu man body through drinking,feeding or breath-ing and then affect cell mitochondria to different degrees.Thus,it is important for preventive medicine to investigate intervention or reduction of the biological da mage of exogenous chemicals′effects on mito-chondria.In this paper,we reviewed the research progress of the role of coenzyme Q in xenobiotics in-duced mitochondrial da mage.

One case of schistosomiasis got drug fever after taking praziquantel.

Objective:To observe the efficacy of A clotrimazole combined with ultrasonic atomization of ozone in the treatment of candidal vaginitis. Methods:Totally 200 cases of candidal vaginitis were divided into the observation group and the control group with 100 cases in each. The control group was given A clotrimazole creams through vaginal administration, qd, while the observation group was treated by ultrasonic atomization of ozone additionally, qd, 15min per time with five times. The clinical efficacy and the recurrence rate after 6 months of the two groups were compared. Before the treatment and in the first and fourth week after the treatment, vaginal secretion bacterial culture was performed and pH value was detected. Results:The cure rate and the total effective rate of the observa-tion group was 88% and 98%, respectively, which was significantly higher than that of the control group (69% and 82%, respective-ly, P<0. 05). After the 6-month follow-up, the recurrence rate was 1. 0% in the observation group (1/98), which was significantly lower than that in the control group [7. 3%(6/82),P<0. 05]. After the treatment, the vaginal pH value in the observation group was reduced notably and the number of lactobacillus was increased significantly(P<0. 05), while those in the control group were without significant changes (P>0. 05). Conclusion:A clotrimazole combined with ultrasonic atomization of ozone in the treatment of candidal vaginitis can improve the therapeutic effect.

Objective To find out the quality of brain function electromagnetic adjuvant therapy for neurosis treatment.Methods 100 patients were randomly divided into two groups,study group(50 cases)was treated for brain function by electromagnetic therapy with the drug treatment,and only drug treatment was used for the control group(50 cases).The psychological symptom checklist(SCL-90)and Pittsburgh Sleep Quality Index Scale(PSQI)were used to assess clinical symptoms and sleep quality of the two groups before and after therapy of 30 days,and the scale results were compared.Results After treatment,somatization,interpersonal sensitivity,anxiety,depression,hostility,phobia,obsessive-compulsive disorder,paranoid and psychotic items score of SCL-90 scale of study group was significantly lower than the scale before treatment(all P ＜0.05);after treatment somatization and anxiety item scores of SCL-90 scale of study group were significantly lower than the control group(all P ＜0.05).After treatment PSQI total scale score,sleep latency,sleep continuity,sleep efficiency,the use of sleep medications and sleep disorders of study group were significantly lower than before treatment(all P ＜ 0.01);after treatment PSQI total scale score and all items scores of study group were significantly lower than the control group(all P ＜ 0.05).Conclusion Adjuvant treatment of brain electromagnetic had significant effects of improving sleep quality,relieving anxiety and somatization for neurological patients.

Climacteric ; Drug Therapy, Combination ; Drugs, Chinese Herbal ; therapeutic use ; Female ; Humans ; Hyperthyroidism ; drug therapy ; Methimazole ; therapeutic use ; Middle Aged ; Phytotherapy

The conception of nutrition risk and malnutrition risk are not strictly differentiated in clinical.Nutri-tional risk was associated with a higher complications incidence,mortality and longer length of hospital stay.It′s nece-ssary to carry out nutrition risk screening to decide whether the need for nutritional intervention.This article introduces the clinical epidemiological characteristics of nutritional risk in children,nutrition risk score,nutritional risk screening, subjective global assessment,and screening tool for risk of impaired nutritional status and growth.It′s very important to apply a rapid and easy nutrition risk screening tools.Then,also discussions the relationship between nutritional risk screening and nutritional therapy,put forward on the strategies for assess and prevent malnutrition in children,and loo-king for the best way of nutritional support to ensure the body and cells metabolism,reduce the extent of tissue damage and promote the recovery of the disease.

OBJECTIVE: To observe the protective effect of Hugan granules on the acute liver injury model mice. METHODS: Acute liver injury model was induced by intraperitoneal injection of 0.12% chloroform-peanut oil solution. The histopathological changes of the liver tissues were observed under microscope. The activities of ALT, AST and SOD and the content of MDA in the liver tissues were determined and the liver indexes were calculated. RESULTS: Hugan granules at high, medium and low doses could significantly lower serum ALT and AST activities, enhance the activity of SOD, and lower both MDA content and the liver index. CONCLUSION: Hugan granules have a certain protective effect on the acute liver injury.

OBJECTIVE:To observe the antiaging effect of celery seed oil (CSO) on aging mice and rats induced by D-galactose. METHODS: Aging models were established with D-galactose hypo. At the same time, the model animals were intragastrically given CSO. After 6 weeks, the effects of CSO on learning and memory were evaluated by step down test and electrophysiological test. And the MDA content, MAO-B and SOD activity in brains of aging mice were measured. RESULTS: CSO can markedly improve the learning and memory of aging mice and rats, reduce the content of MDA and activity of MAO-B, and increase SOD activity. CONCLUSION: CSO has good antiaging effect.

OBJECTIVE:To compare the differences between Hongkong and mainland China in Chinese medicine pharmacy management for reference of improvement of Chinese medicine pharmacy management in both Hongkong and mainland China.METHODS:The management system of Chinese medicinal decoction pieces,Chinese patent medicine and special drugs etc in Hongkong vs.in mainland China were evaluated.RESULTS:The management of Chinese medicine pharmacy in Hongkong is more standard,but there is lack of Chinese medicine pharmacists engaged in Chinese medicine pharmacy management and pharmacy work.The management system of Chinese medicine pharmacy in mainland China remains to be improved.CONCLUSION:It is essential for Hongkong to strengthen the training of local Chinese medicine pharmacists;and in mainland China,great importance should be attached to the management system of Chinese medicine pharmacy.

Objective To investigate the clinical efficacy of Dong’s extra point opposing needling in treating facial paralysis. Methods Ninety patients with facial paralysis were randomly allocated to treatment and control groups, 45 cases each. In addition to the basic medicine treatment, the treatment group received Dong’s extra point opposing needling and the control group, conventional acupuncture. Facial nerve function was scored using the House-Brackmann (H-B) Facial Nerve Grading System in the two groups of patients before and after treatment. The clinical therapeutic effects were compared between the three groups.Results There were statistically significant post-treatment differences in the H-B scores of various time points between the treatment and control groups (P<0.05). The total efficacy rate and the cure rate were 100.0% and 68.9%, respectively, in the treatment group and 100.0% and 48.9%, respectively, in the control group. There was a statistically significant difference in the cure rate between the two groups (P<0.05). The time needed for cure was (20.15±3.30) days in the treatment group and (28.41±4.92) days in the control group; there was a statistically significant difference between the two groups (P<0.05).Conclusion Dong’s extra point opposing needling plus medication is an effective way to treat facial paralysis.