Coenzyme Q (CoQ),also known as ubiquinone,is a lipid-soluble quinone compound which exists in biological organis ms widely.The numbers of side chain isoprene of different sources of coenzyme Q are different.Coenzyme Q in humans and mammals are called coenzyme Q10 (CoQ10 ,Q10 ), in that the ubiquinone side chain of humans and mammals are mainly composed of 10 isoprene units.In the mitochondrial respiratory chain,it acts as a mobile electron transporter and is a cofactor of uncoup-ling proteins,which is an essential endogenous substance in the process of cell respiration and metabo-lis m.Moreover,CoQ possesses independent antiapoptosis feature,which regulates the mitochondrial permeability transition pore.Mitochondrion is an important organelle,which is the place for energy stor-age and supply,providing the energy for vital movement.There are various kinds of chemical toxicants in the hu man environ ment,and they can enter into the hu man body through drinking,feeding or breath-ing and then affect cell mitochondria to different degrees.Thus,it is important for preventive medicine to investigate intervention or reduction of the biological da mage of exogenous chemicals′effects on mito-chondria.In this paper,we reviewed the research progress of the role of coenzyme Q in xenobiotics in-duced mitochondrial da mage.

Objective To find out the quality of brain function electromagnetic adjuvant therapy for neurosis treatment.Methods 100 patients were randomly divided into two groups,study group(50 cases)was treated for brain function by electromagnetic therapy with the drug treatment,and only drug treatment was used for the control group(50 cases).The psychological symptom checklist(SCL-90)and Pittsburgh Sleep Quality Index Scale(PSQI)were used to assess clinical symptoms and sleep quality of the two groups before and after therapy of 30 days,and the scale results were compared.Results After treatment,somatization,interpersonal sensitivity,anxiety,depression,hostility,phobia,obsessive-compulsive disorder,paranoid and psychotic items score of SCL-90 scale of study group was significantly lower than the scale before treatment(all P ＜0.05);after treatment somatization and anxiety item scores of SCL-90 scale of study group were significantly lower than the control group(all P ＜0.05).After treatment PSQI total scale score,sleep latency,sleep continuity,sleep efficiency,the use of sleep medications and sleep disorders of study group were significantly lower than before treatment(all P ＜ 0.01);after treatment PSQI total scale score and all items scores of study group were significantly lower than the control group(all P ＜ 0.05).Conclusion Adjuvant treatment of brain electromagnetic had significant effects of improving sleep quality,relieving anxiety and somatization for neurological patients.

Objective:To observe the efficacy of A clotrimazole combined with ultrasonic atomization of ozone in the treatment of candidal vaginitis. Methods:Totally 200 cases of candidal vaginitis were divided into the observation group and the control group with 100 cases in each. The control group was given A clotrimazole creams through vaginal administration, qd, while the observation group was treated by ultrasonic atomization of ozone additionally, qd, 15min per time with five times. The clinical efficacy and the recurrence rate after 6 months of the two groups were compared. Before the treatment and in the first and fourth week after the treatment, vaginal secretion bacterial culture was performed and pH value was detected. Results:The cure rate and the total effective rate of the observa-tion group was 88% and 98%, respectively, which was significantly higher than that of the control group (69% and 82%, respective-ly, P<0. 05). After the 6-month follow-up, the recurrence rate was 1. 0% in the observation group (1/98), which was significantly lower than that in the control group [7. 3%(6/82),P<0. 05]. After the treatment, the vaginal pH value in the observation group was reduced notably and the number of lactobacillus was increased significantly(P<0. 05), while those in the control group were without significant changes (P>0. 05). Conclusion:A clotrimazole combined with ultrasonic atomization of ozone in the treatment of candidal vaginitis can improve the therapeutic effect.

One case of schistosomiasis got drug fever after taking praziquantel.

BACKGROUND:Prosthetic appliance is often adopted for clinical maxilary repair, which can maintain swalowing and language function in patients with a certain extent, but if the defect is too large, the prosthesis has a poor fixed effect that is prone to inducing various adverse consequences. OBJECTIVE:To explore the maintenance effect of titanium mesh combined with forearm free flap on swalowing and language function in patients with maxilary defects. METHODS:A total of 35 patients with maxilary defects, 19 males and 16 females, aged 33-93 years, were enroled. Among them, 17 patients underwent maxilectomy and wound packing with iodoform gauzes, and then after 1 year, these patients were given prosthesis repair as control group; another 18 patients were subjected to titanium mesh combined with forearm free flap for repair of maxilary defects as observation group. Al the patients were folowed up for 24 months, and the swalowing and language functions were evaluated. RESULTS AND CONCLUSION:At 24 months after repair, al the patients were satisfied with facial appearance, and there were no adverse reactions related to repair materials. Scores on swalowing function, language function, pain fucntion, face function, motor function, entertainment function, masticatory function and oral health were significantly higher in the observation group than the control group (P < 0.05), and the score on the shoulder dysfunction was lower in the observation than the control group, indicating the patients in the observation group had a higher quality of life than those in the control group. These findings indicate that titanium mesh combine with forearm free flap for maxilary defect repair can be better to maintain the swalowing and language function of patients.

The profit-seeking mechanism which has emerged as an unexpected result of a series of policy choices during the market-oriented healthcare reform is the root cause of almost all problems among the public hospi-tals, and hence the key to the public hospital reform.The mechanism is comprised by three components including the pressure mechanism to create the revenue, the enlargement mechanism to reimburse costs, and the linkage mecha-nism between employee income and hospital surplus.Therefore, a comprehensive policy package should be adopted to undertake these three aspects among which the linkage mechanism is the crucial one.

Adrenocortical hormone (ACH) has been used in the treatment of the epilepsies,especially for epileptic encephalopathy,for over 70 years.ACH is clearly established as fast line treatment of infantile spasm and the Landau-Kleffner syndrome.This is typically as monotherapy in infantile spasm,but often in conjunction with anti-epileptic drugs in Landau-Kleffner syndrome,though the mechanism of ACH for epilepsies is not clear.However,in view of these potential adverse side effects,the use of ACH in the treatment of the epilepsies in children must be determined on a risk-benefit basis.

Objective To improve the prevention and control of hospital infection by real-time monitoring of hospital infection, identifying and early warning of hospital infection cases.Methods A hospital infection real-time monito-ring system was designed using computer network techniques according to the PDCA design concept in combination with practical experiences .Results The hospital infection real-time monitoring system could monitor the hospitalized patients and early warn the suspected patients.The system maintenance technicians and medical staff participated in the diagnosis of hospital infection through the information interaction platform and a complete hospital infection management network system was thus formed.Conclusion Hospital infection management and hospital infection monitoring are improved through the highly effective early warning and clinical intervention-feedback mechanism , thus a novel model is established for the prevention and control of hospital infection.

Objective: To research the application of dynamic-network probation in combination with traditional clinic probation in surgical practice teaching. Methods:Sixty four people in the undergraduate 2012(1, 2 session) set as the experimental group. 40 people in the undergraduate 2012(biochemical class) set as the control group. The traditional clinic probation was applied to the control group. The traditional clinic probation was applied to the control group. The dynamic-network probation in combination with traditional clinic probation was applied to experimental group. The teaching effects were evaluated and compared roundly. Results:The teaching effects of experimental group was significantly better than control group in all respects (x2=7.512, x2=6.797, x2=7.778, x2=4.768, x2=8.541;P<0.05). Satisfaction ratio of experimental group was significantly higher than that of control group in all respects of surgery teaching (x2=4.475, x2=5.900, x2=5.005, x2=5.904, x2=4.502; P<0.05). The examination performance of experimental group was significantly better than control group in theoretical knowledge and clinical skills testing (t=25.840, t=19.319;P<0.05). Conclusion:Dynamic-network probation in combination with traditional clinical probation has a great effect on surgical practice teaching and worth to be applied.

Objective To study the effect of atomized inhalation of pulmicort respules combined with tulobuterol in the treatment of children with wheezing pneumonia and its influence on serum inflammatory factors.Methods 90 children with asthmatic bronchopneumonia were selected,and they were randomly divided into observation group and control group,45 cases in each group.The control group received routine western medicine and atomized inhalation of ambroxol hydrochloride.The observation group was treated with pulmicort respules inhalation combined with tulobuterol paste service on the basis of the control group.After 1 course of treatment,the efficacy was evaluated.The improvement of clinical symptoms,clinical efficacy,serum cytokine level,inflammatory index and adverse reaction were compared between the two groups.Results The disappearance time of clinical signs such as shortness of breath,cough,wheezing and pulmonary rales in the observation group were significantly shorter than those in the control group [(7.58±0.72)d,(8.42±1.33)d,(5.66±0.74)d,(7.76±0.75)d vs.(4.21±0.29)d,(2.59±0.71)d,(3.41±0.69)d,(5.29±0.71)d,P<0.01],and there were statistically significant differences between the two groups(t=29.124,25.940,14.913,16.044,all P<0.05).The total effective rate in the observation group was 93.3%,which was significantly higher than 80.0% in the control group(χ2=5.214,P<0.01).There was no significant difference in the ECP and Eos levels between the two groups before treatment(P>0.05).The ECP and Eos in the peripheral blood of the two groups were significantly lower than those before treatment(t=8.363,4.307,13.431,12.949,all P<0.05).The ECP and Eos of the observation group were significantly lower than those of the control group(t=7.792,5.838,all P<0.05).IL-4,IL-6 and IL-10 in peripheral blood of the two groups before treatment were not significantly different(all P>0.05).After treatment,the levels of IL-4,IL-6 and IL-10 were significantly decreased and the IFN-γ level was significantly higher than before treatment(t=17.216,20.051,17.891,15.417,32.724,26.709,28.112,26.708,all P<0.05).The levels of inflammatory cytokines in the peripheral blood of the observation group were significantly better than those of the control group(t=9.306,4.150,5.117,4.124,all P<0.05).No serious adverse events occurred in the two groups during the treatment.Conclusion Pulmicort respules combined with tulobuterol is effective in the treatment of children with wheezing pneumonia.It can relieve the symptoms of cough and wheezing.The mechanism may be related to the imbalance of Th1/Th2 imbalance and the reduction of airway inflammation.