Objective:To observe the efficacy of A clotrimazole combined with ultrasonic atomization of ozone in the treatment of candidal vaginitis. Methods:Totally 200 cases of candidal vaginitis were divided into the observation group and the control group with 100 cases in each. The control group was given A clotrimazole creams through vaginal administration, qd, while the observation group was treated by ultrasonic atomization of ozone additionally, qd, 15min per time with five times. The clinical efficacy and the recurrence rate after 6 months of the two groups were compared. Before the treatment and in the first and fourth week after the treatment, vaginal secretion bacterial culture was performed and pH value was detected. Results:The cure rate and the total effective rate of the observa-tion group was 88% and 98%, respectively, which was significantly higher than that of the control group (69% and 82%, respective-ly, P<0. 05). After the 6-month follow-up, the recurrence rate was 1. 0% in the observation group (1/98), which was significantly lower than that in the control group [7. 3%(6/82),P<0. 05]. After the treatment, the vaginal pH value in the observation group was reduced notably and the number of lactobacillus was increased significantly(P<0. 05), while those in the control group were without significant changes (P>0. 05). Conclusion:A clotrimazole combined with ultrasonic atomization of ozone in the treatment of candidal vaginitis can improve the therapeutic effect.

Coenzyme Q (CoQ),also known as ubiquinone,is a lipid-soluble quinone compound which exists in biological organis ms widely.The numbers of side chain isoprene of different sources of coenzyme Q are different.Coenzyme Q in humans and mammals are called coenzyme Q10 (CoQ10 ,Q10 ), in that the ubiquinone side chain of humans and mammals are mainly composed of 10 isoprene units.In the mitochondrial respiratory chain,it acts as a mobile electron transporter and is a cofactor of uncoup-ling proteins,which is an essential endogenous substance in the process of cell respiration and metabo-lis m.Moreover,CoQ possesses independent antiapoptosis feature,which regulates the mitochondrial permeability transition pore.Mitochondrion is an important organelle,which is the place for energy stor-age and supply,providing the energy for vital movement.There are various kinds of chemical toxicants in the hu man environ ment,and they can enter into the hu man body through drinking,feeding or breath-ing and then affect cell mitochondria to different degrees.Thus,it is important for preventive medicine to investigate intervention or reduction of the biological da mage of exogenous chemicals′effects on mito-chondria.In this paper,we reviewed the research progress of the role of coenzyme Q in xenobiotics in-duced mitochondrial da mage.

Objective To find out the quality of brain function electromagnetic adjuvant therapy for neurosis treatment.Methods 100 patients were randomly divided into two groups,study group(50 cases)was treated for brain function by electromagnetic therapy with the drug treatment,and only drug treatment was used for the control group(50 cases).The psychological symptom checklist(SCL-90)and Pittsburgh Sleep Quality Index Scale(PSQI)were used to assess clinical symptoms and sleep quality of the two groups before and after therapy of 30 days,and the scale results were compared.Results After treatment,somatization,interpersonal sensitivity,anxiety,depression,hostility,phobia,obsessive-compulsive disorder,paranoid and psychotic items score of SCL-90 scale of study group was significantly lower than the scale before treatment(all P ＜0.05);after treatment somatization and anxiety item scores of SCL-90 scale of study group were significantly lower than the control group(all P ＜0.05).After treatment PSQI total scale score,sleep latency,sleep continuity,sleep efficiency,the use of sleep medications and sleep disorders of study group were significantly lower than before treatment(all P ＜ 0.01);after treatment PSQI total scale score and all items scores of study group were significantly lower than the control group(all P ＜ 0.05).Conclusion Adjuvant treatment of brain electromagnetic had significant effects of improving sleep quality,relieving anxiety and somatization for neurological patients.

One case of schistosomiasis got drug fever after taking praziquantel.

25-Hydroxyvitamin D deficiency is prevailing in patients with chronic kidney disease,Vitamin D in addition to influence the metabolism of calcium and phosphorus,also participates in regulation of renal anemia.This paper will be reported 25-Hydroxyvitamin D regulates renal anemia from three aspects of the relationship of vitamin D and iron metabolism,erythropoietin (EPO) and micro inflammation.

Tai Chi Chuanis a traditional Chinese method of regimen and health care, which has attracted wide attention from countries in the world. This article was aimed to analyze the current situation and hot spots about Tai Chi Chuan for future research. A total of 1349 articles were retrieved from Web of Science from 1981 to 2013. CiteSpace was used to map knowledge domain of 1349 articles in order to explore the current situation and hot spots aboutTai Chi Chuan internationally. The results showed that the research onTai Chi Chuan showed a rising trend. The main research regions were in the United States and China. The research fields were extended from medicine and sport science to psychology, engineering and computer science. The hot spots were focused on physical control, psychology and cardiovascular diseases. It was concluded thatTai Chi Chuan was a method benefit to both physical and mental health. The focus of future Tai Chi Chuan research was on basic theory, action mechanism and strict evidences.

Objective To improve the prevention and control of hospital infection by real-time monitoring of hospital infection, identifying and early warning of hospital infection cases.Methods A hospital infection real-time monito-ring system was designed using computer network techniques according to the PDCA design concept in combination with practical experiences .Results The hospital infection real-time monitoring system could monitor the hospitalized patients and early warn the suspected patients.The system maintenance technicians and medical staff participated in the diagnosis of hospital infection through the information interaction platform and a complete hospital infection management network system was thus formed.Conclusion Hospital infection management and hospital infection monitoring are improved through the highly effective early warning and clinical intervention-feedback mechanism , thus a novel model is established for the prevention and control of hospital infection.

Objective: To research the application of dynamic-network probation in combination with traditional clinic probation in surgical practice teaching. Methods:Sixty four people in the undergraduate 2012(1, 2 session) set as the experimental group. 40 people in the undergraduate 2012(biochemical class) set as the control group. The traditional clinic probation was applied to the control group. The traditional clinic probation was applied to the control group. The dynamic-network probation in combination with traditional clinic probation was applied to experimental group. The teaching effects were evaluated and compared roundly. Results:The teaching effects of experimental group was significantly better than control group in all respects (x2=7.512, x2=6.797, x2=7.778, x2=4.768, x2=8.541;P<0.05). Satisfaction ratio of experimental group was significantly higher than that of control group in all respects of surgery teaching (x2=4.475, x2=5.900, x2=5.005, x2=5.904, x2=4.502; P<0.05). The examination performance of experimental group was significantly better than control group in theoretical knowledge and clinical skills testing (t=25.840, t=19.319;P<0.05). Conclusion:Dynamic-network probation in combination with traditional clinical probation has a great effect on surgical practice teaching and worth to be applied.

BACKGROUND:Studies have shown that emodin protects against intestinal ischemia-reperfusion injury by inhibiting the release of inflammatory factors. OBJECTIVE:To investigate the effect of emodin on renal ischemia/reperfusion injury after bone marrow mesenchymal stem cel transplantation. METHODS:Forty Sprague-Dawley rats were randomized into five groups (n=8 per group):sham group, model group (renal ischemia/reperfusion injury group), bone marrow mesenchymal stem cel group (cel transplantation group), low-dose emodin group, high-dose emodin group. Rats in the latter four groups were pretreated with or without different concentrations (30 and 60 mg/kg) of emodin for 7 days, and then were subjected to clamping bilateral renal pedicles for 45 minutes, fol owed by injection of 1 mL bone marrow mesenchymal stem cel suspension. Six hours after reperfusion, the pathological changes of renal tissues were examined by hematoxylin-eosin staining;the mRNA levels of tumor necrosis factorα, interleukin-6, interleukin-18, TLR2 and TLR4 detected by real-time fluorescence quantitative PCR;and the protein expression of COX-2, ICAM-1 and iNOS determined by western blot. RESULTS AND CONCLUSION:Compared with the sham group, rats in the model group showed obvious features of severe acute tubular damage and inflammatory cel infiltration. In the cel transplantation group, tubular epitheliael cel s were partial y lost with some inflammatory cel s infiltrated in the renal interstitium. In the emodin groups, the tubular lumen was practical y intact with little renal interstitial inflammatory cel s. Compared with the sham group, a significant increase in the mRNA levels of tumor necrosis factorα, interleukin-6, interleukin-18, TLR2 and TLR4 as wel as in the protein levels of COX-2, ICAM-1 and iNOS was found in the model group (both P<0.05). However, bone marrow mesenchymal stem cel transplantation attenuated this ischemia/reperfusion-induced increase in the expression of the above-mentioned factors (P<0.05). Furthermore, the effects of bone marrow mesenchymal stem cel transplantation were further augmented by pretreatment with emodin in a dose-dependent manner. These findings suggest that emodin can enhance the protective effects of bone marrow mesenchymal stem cel s on renal ischemia/reperfusion injury.

Objective To investigate the clinical efficacy of Dong’s extra point opposing needling in treating facial paralysis. Methods Ninety patients with facial paralysis were randomly allocated to treatment and control groups, 45 cases each. In addition to the basic medicine treatment, the treatment group received Dong’s extra point opposing needling and the control group, conventional acupuncture. Facial nerve function was scored using the House-Brackmann (H-B) Facial Nerve Grading System in the two groups of patients before and after treatment. The clinical therapeutic effects were compared between the three groups.Results There were statistically significant post-treatment differences in the H-B scores of various time points between the treatment and control groups (P<0.05). The total efficacy rate and the cure rate were 100.0% and 68.9%, respectively, in the treatment group and 100.0% and 48.9%, respectively, in the control group. There was a statistically significant difference in the cure rate between the two groups (P<0.05). The time needed for cure was (20.15±3.30) days in the treatment group and (28.41±4.92) days in the control group; there was a statistically significant difference between the two groups (P<0.05).Conclusion Dong’s extra point opposing needling plus medication is an effective way to treat facial paralysis.