1.Anti-inflammatory activity and wound healing effect of the gingita® natural essential oils mouth wash in rats
Bazarragchaa Ts ; Uuganbayar B
Innovation 2018;12(4):63-
Essential oils have evoked interest as sources of natural products, which their potential uses an alternative remedies for the treatment of many infectious disease and to restore healing mouth sores or kill oral bacteria. Gum disease is one of the major factor for systemic disease, which to recommend the latest study of world medical scientist. This study aimed to evaluate the anti-inflammatory activity and wound healing effect of the GINGITA® natural essential oils mouth wash in rats.
Treatment was by topical application of the GINGITA® natural essential oils mouth wash onto wound surface for 21 days. Wistar rats divided into 2 groups of 15 animals each and anesthesia was administered. The dorsal area of skin of the each rats was shaved and clipped fully-thickness 10x10mm skin wound was made. The test group was treated with GINGITA® natural essential oils mouth wash, which control group untreated.
A better healing pattern was observed in rats treated with GINGITA® natural essential oils mouth wash compared with the control group. There was a significant reduction in wound length and closure rats was faster treated by GINGITA® natural essential oils mouth wash compared with control group. Immunohistochemical analysis demonstrated that an increase of epithelial cells in wound lesions treated with GINGITA® natural essential oils mouth wash wish as compared untreated control group. Conclusions: The present study revealed that GINGITA® natural essential oils mouth wash may be effective in stimulating the enclosure of wounds in sort period time.
2.Major types and prevalence of developmental disabilities in children aged 0-14
Bertsetsegmaralmaa B ; Bold Sh ; Bazarragchaa S
Mongolian Pharmacy and Pharmacology 2021;19(2):77-87
Introduction:
Children with disabilities are at greater risk of childhood developmental delays, yet often excluded from the public child development services and programs4. The Convention on the Rights of the Child5 (UNCRC) and The Convention on the Rights of Persons with Disabilities6 (CRPD) points out that children with disabilities have the same rights as every child, such as access to health care, nutrition, education, equal participation in society, and protection from violence and neglect7.
Objective:
To study the types and prevalence of predominant disabilities of Mongolian in young children
Materials and methods:
Predominant types, prevalence and proportion of children with disabilities aged 0-14 years are as of 2019 generated from Report of the National Center for Rehabilitation and Development for period 2017-2020, Report of the National Statistical Office of the disabled for period 2019-2020 and Report for Issues of people with disability: Policies and activities Information directory Center, Ministry of Labor and Social Welfare, for period 2017-2020.
Result and conclusionchildren; disabilities; prevalence
As of 2019, there are 8981 (8.4%) children with disabilities aged 0-14 in Mongolia, of which 7075 (78.8%) have congenital disabilities and 1906 (21.2%) have acquired disabilities. By age group, the prevalence of congenital disabilities is 78.2% higher among children aged 0-14. Of these, 1,790 children have lost their ability to function on a daily activity due to a congenital disease, 1474 children with congenital physical disabilities, 1368 children with mental and intellectual disabilities, 749 children with co-morbidities, 741 children with visual impairments, 573 children with speech disabilities and 380 children with hearing impairments.
3.Understanding and assessment menthods of occupational burnout syndrome
Mendbayar Ch ; Bazarragchaa S ; Dariimaa B
Mongolian Pharmacy and Pharmacology 2023;22(1):28-33
Background:
As the trend of pharmaceutical care around the world shifts to client-centered care, there is a need for new pharmacists to improve their knowledge and skills, learn psychological skills, provide customers with health education, and improve the rational use of drugs and pharmacological services.
Objective:
This study is based on the fact that no research has been conducted in Mongolia on factors that affect burnout syndrome and social-psychology of pharmacists.
Literature review:
The following are internationally accepted methods of assessing sociopsychological risks to determine the socio-psychological factors associated with the work and occupation of workers and their impact on health and safety. These include:
Burnout Measue-BM, 1981 (Pines & Aronson 1988). A method of measuring burnout, physical and emotional fatigue, and mental exhaustion. (Bazarragchaa, 2020)
The Copenhagen Psychosociol Questionnaire COPSOQ (Christenson et al. 2005) focuses on socio-psychological factors, stress, personal health, well-being and individual factors (style, sense of mutual understanding, etc.).
The Copenhagen Burnout Inverntory (CBI, 2005) examines fatigue, exhaustion, and work-related
burnout as well as customer-related burnout.
Conclusion
There are more than 40 definitions of “Burnout syndrome”. The “Maslach Burnout Inventory” has become the “Gold standard” for assessing the burnout of service workers. The Copenhagen Burnout Inverntory (CBI, 2005) studies fatigue, exhaustion, and individual, work-related and customer-related burnout.
4.Results of study on road traffic accidents in relation to road condition between Baganuur and Ulaanbaatar
Myagmarjav J ; Bazarragchaa I ; Khashbat J ; Erdenetuya A ; Munkhzul N ; Tsevegjav TS
Mongolian Medical Sciences 2012;161(3):37-43
Background. In Mongolia, 320-350 people died per year due to traffic accidents. About 193 people were died in road of rural area. According to statistic, focusing on the accidents’ reason, about 94.9 percent of accidents are caused by faulty operation of driver and 0.4 percent is caused by road condition. Goal. The purpose of this study was to analyse the influence of road condition on the route Ulaanbaatar- Baganuur, where traffic accident have frequently occurred and through that find solutions to relieve the traffic accidents.Materials and Methods. Traffic safety was evaluated with coefficient of traffic safety that defined as divide the safe speed of vehicle on the road with invisible area such as crest and sag vertical curve and horzintal curve to the speed of vehicles from opposide direction. The average speed of vehicle on hill by having invisible of road curve inside, the end of road ascent and the road section that broke road asphalt surface were determined by stability and steering dynamic calculation.Result. According to the study, on the route Ulaanbaatar-Baganuur, within last three years, about 37 accidents were occurred. Accidents and conditions on the 14 stretches where accidents have frequently occurred were studied and analyzed by repetition, location and road condition and similarity of neighbor points, so on the 14 stretches, the accidents were occurred frequently. From those accidents, 24 people died and 87 people were injured. Classifying the accidents with 14 stretches, about 14 percent of accidents were occurred on the end of road ascent; 28 percent on straight section; 35 percent on curve; 16 percent on broken surface section of road; 7 percent on the place that road asphalt surface was missed partially. Decreasing the average speed of vehicle to 54.6 km/h on hill by having invisible of road curve inside, 64.2 km/h on the end of road ascent and 51.5 km/h on the road section that broke road asphalt surface were required.Conclusion. The coefficients of traffic safety are had between 0.30-0.81 on the sections that required limiting the traffic speed. In other words, the technical environment of traffic accidents consists on some points of this road.
5.A Kinship Analysis of Ancient Human Bones and Teeth from Mongolia.
Munkhtsetseg BAZARRAGCHAA ; Kijeong KIM ; Jae Hyun KIM ; Gavaachimed LKHAGVASUREN ; Ae Ja PARK ; Kwang Ho LEE ; Dae Jin KIM ; Yoon Hee CHUNG ; Sung Su KIM ; Won Bok LEE ; Kyung Yong KIM
Korean Journal of Physical Anthropology 2009;22(4):255-268
The kinship was analyzed genetically on the three 2000 year old ancient human bones and teeth excavated in Mongolia. The samples were processed in a clean room to prevent the contamination from modern human DNA. The DNA extraction and purification was done with ion-exchange column kit (Qiagen G-tip 20G, USA). The PCR was done with purified DNAs from ancient human bones for paternal Y-SNP haplogroup, maternal mtDNA haplogroup, and autosomal short tandem repeats (STR). Two samples belonged to the maternal D major haplogroup, which is one of the most frequent types in the present North East Asia. One of them, showing male genotype, belonged to the paternal C major haplogroup, which is also one of the most frequent types in the present North East Asia. The remaining one belonged to the paternal R major haplogroup, frequent in the present Europe, and the maternal U haplogroup, frequent in the present Europe and East Mediterranean. The repeated results were consistent in the autosomal STR PCR. The STR data were analyzed with DNA-VIEW program (http://www.dna-view.com), which showed no close kinship among the three ancient humans. Our method was successful in the analyzing kinship among ancient human bones, which has been possible in few restricted laboratories in the World. Authors anticipate that many researchers could do their research in a better way to get the genetic information from ancient human bones.
DNA
;
DNA, Mitochondrial
;
Environment, Controlled
;
Europe
;
Far East
;
Genotype
;
Humans
;
Male
;
Microsatellite Repeats
;
Mongolia
;
Polymerase Chain Reaction
;
Tooth
6.The most frequently used medical raws for the treatment of
Delgermaa E ; Ambaga M ; Khurelchuluun B ; Bolor B ; Bazarragchaa
Mongolian Pharmacy and Pharmacology 2019;15(2):12-15
Background:
Some findings of an artifacts have revealed that nature based the raw have been used for the treatment of mankind's diseases over 60 000 years ago. WHO estimates that about 80 percentage of the world's population are consume the traditional medical care, and uses more than 21,000 plant species for therapeutic purposes. In order to help guide its member countries the World Health Organization (WHO) has developed The WHO Traditional Medicine Strategy 2014-2023. Some of the strategic actions in this document include:
• To develop and share appropriate research methodologies and criteria for evaluating the safety, efficacy, and quality of TM (Traditional Medicine) products;
• To study and explain the disease prevention, health maintenance, the diagnosis and the treatment of the TM disease according to the evidence based scientific studies.
Objectives:
to determine the most frequently used medicinal plants for the treatment of "Rlung" in the TM.
Methods:
The comparison method, the synthesis and analysis method, the induction and deduction method, the listing and sorting method, the inspecting and arrange method, and the methods of documents' drafting were used in this study.
Results:
It is shown that over 80 raw materials of plant, mineral and animal origins has to list within 32 drug recipes which used "Rlung" disease of TM. The first five raw materials from these 80 ingredients have been repeatedly lists zadi - 30, agar (black, white, red agar) -19, arur-19, lish -18, and nin shosh -18 times.
Conclusion
The most frequently used the raw materialin the treatment of "Rlung" diseases is the seeds of Myristica fragrans Houtt. which contains a lot of the saturated acids with membrane-enhancing effects and strong antioxidant substances.
7.HLA-DRB1 Study of DNA from Ancient Human Skeleton by Sequence-based Typing.
Ji Young WOO ; Kijeong KIM ; Bazarragchaa MUNKHTSETSEG ; Jae Hyun KIM ; Gavaachimed LKHAGVASUREN ; Dong Suep SOHN ; Ae Ja PARK ; Kwang Ho LEE ; Dae Jin KIM ; Yoon Hee CHUNG ; Sung Su KIM ; Won Bok LEE ; Kyung Yong KIM
Korean Journal of Physical Anthropology 2010;23(2):49-60
The analysis of ancient human DNA is increasingly used recently in the study of anthropology and human evolution. Although mitochondrial DNA and Y chromosomal DNA has commonly been the target in the field of human DNA study, HLA analysis of ancient human DNA is extremely rare. This study aimed to develop the PCR method of ancient human DNA for analyzing the sequence of HLA. Authors established a new method for HLA-DRB1 analysis by sequence-based typing. Alleles of HLA-DRB1 were analyzed and typed by sequencing with DNA of ancient human skeletons from Korea and Mongolia 3000-500 years ago. The types of HLA-DRB1 were determined by comparing the sequences with those of HLA database (http://www. ebi.ac.uk/Tools/blast2/nucleotide.html). The alleles of HLA-DRB1 of ancient human DNA from Korea and Mongolia were classified by types. The frequencies of HLA-DRB1 types of Mongolia were also presented according to the geography such as West, Central, East, and North. In summary, our method was successful in the analyzing the type of HLA-DRB1 from DNA of ancient human bones. Authors anticipate that many researchers could do their research in a better way to get the genetic information for the kinship analysis between individuals or communities from ancient human bones.
Alleles
;
Anthropology
;
DNA
;
DNA, Mitochondrial
;
Geography
;
HLA-DRB1 Chains
;
Humans
;
Korea
;
Mongolia
;
Polymerase Chain Reaction
;
Skeleton
8.The result of the changes of the work-related stress of physicians and nurses with the critical ill patient units
Bazarragchaa S ; Munkh-Erdene L ; Khishigsuren Z ; Delgermaa E ; TSeden P
Mongolian Pharmacy and Pharmacology 2019;15(2):7-11
Background:
The career and work of medical workers are considered to be the occupation of
the highly responsible job of the worldwide.
Goal:
To identify the percentage of the work-related stress, the burnout, and the symptoms of
work-related stress of the physicians and nurses who is working at the critical and intensive care
units of UB hospitals.
Materials and methodology:
The survey was done by quantitative methods and cross sectional design. The study data was collected using the validated questionnaire for the work related stress. The results of the study were analyzed by the Microsoft Excel and SPSS 20 program.
Results
The response rate was 97.3% The study found that 78.7% of respondents reported having regular stress; and 89.4% of all participants in the survey had a personal burnout, 90.4% had work-related burnout and 94.5% had a high level of client-related burnout.
Physical symptoms include the insomnia 76.7%; psychological symptoms - the headaches 65%; behavioral symptoms as like forgetfulness and annoyance 53.3%; cognitive symptoms as like an increase in sick days or absenteeism by 40% for all physicians and nurses.
9.Comparison study of number of bones in human body of traditional and modern medicine
Tudevdagva L ; Bold Sh ; Tuul Kh ; Ariunjargal T ; Bat-Ochir M ; Bazarragchaa S ; Enkhjin G ; Duutbayr Kh
Mongolian Pharmacy and Pharmacology 2021;18(1):11-16
Background:
During the historical development of traditional medicine, many books and manuscripts have been written in Mongolian medicine. The main textbook of traditional medicine states that: “The size of a bone consists of 23 bone species, 28 spinal joints, 24 ribs, 32 teeth, and 360 pieces of bone.”
However, modern medicine estimates that the human body has 206 bones. Therefore, this topic was chosen to study the source material of traditional medicine, including the structure of the human body, and the number of bones in the modern medical anatomy textbook.
Purpose:
Details of the number of bones in the human body in the “Four Medical Tantras”
(རྒྱུད་བཞི) of traditional medicine and its commentary, as well as compare with the number of bones in the basic textbook of anatomy of modern medicine.
Objectives:
In order to successfully implement the research objectives, the following objectives will be implemented. These include:
1. Sampling and analyzing number of bones from traditional medicine;
2. Sampling and analyzing bone numbers from modern medical textbooks;
3. Compare the names and numbers of bones in traditional medicine and modern medicine
Results:
The number, classification and features of human bones were analyzed from the main scriptures of traditional medicine such as “Explanatory Tantra”, of the “Four Medical Tantras” and the “Legs bshad gser gyi thur ma” by Blo-bzang-chos-grags. In addition, the number of bones in the human body was sampled from modern medical textbooks and prepared for comparison. The number and characteristics of bones in the human body were compared by traditional medicine and modern medicine and made a conclusion.
This study reveals that the foundations for the integrated development of traditional medicine were laid long ago in Mongolian medicine. In addition, to highlight the book “Four Medical Tantras”, which is the basis of the textbook on the structure of the human body and the research work of scientists and scholars, which is considered in Mongolian mamba datsan’s contribution to the science of human anatomy. The importance of this research is to change the extremes of Western medicine and traditional medicine and increase opportunities to use its introduction and development into training and clinical practice.
Conclusion
1. The main creature of body structure in traditional medicine is the “Four Medical Tantras” which generally assumes that the numbers of bones are 360 but does not specify it in detail. During the research, we identified 357 bone names to identify each bone. The names and locations of the three bones were not clearly marked in the medical sources.
2. The numbers of bones are 206 in modern medical textbooks. We recalculated 151 bones based on traditional medical sources without duplication of that.
3. Compared to traditional medicine and modern medicine, the number of bones and are higher than 154 bone names in traditional medicine because we included the number of teeth, small bones in the ears and small bones in the fingers and toes. Some cartilage was also counted as bones.