Background: Class III malocclusion is considered to be one of the most difficult and complex orthodontic problems to treat. For patients whose orthodontic problems are so severe that neither growth modification nor camouflage offers solution, surgery to realign the jaws or reposition dentoalveolar segments is the only possible treatment option left. Objective: The treatment objectives were to: (1) level and align the dental arches; (2) obtain an ideal overbite and overjet, to establish correct anterior guidance; and (3) improve the facial profile. Results: Excellent facial and occlusal results were achieved with this surgical-orthodontic management, post-treatment results showed a Class I relationship and ideal overjet and overbite. The facial profile became straight type. Conclusions This case report describes the treatment of a female with dental and skeletal class III relationships. Surgical-orthodontic treatment was the best option for achieving an acceptable occlusion and a good esthetic result in this case. An experienced multidisciplinary team approach ensures a satisfactory outcome.