The Mongolian plants considered to possess medicinal properties may contain novel compounds since they are exposed to severe conditions; such plants could become good candidates for modern drug discovery programs. Daurian Thermopsis (Thermopsis lanceolata R.Br.= Th.dahurica Czefr.), Gobian Thyme (Thymus gobicus Tschern.) and Mogilev Mallow (Malva mohileviensis Downer) are separately used as mucolytic and anti-inflammatory treatment in non-conventional medicine. Therefore, weprepared extract of these herbals compound called as a Tetima and to evaluate it’s acute toxicity. It isimportant to produce mucolytic effective new pharmaceutical preparation used for upper and lowerrespiratory tract inflammatory disease.Tetima herbal compound extract was prepared in ethanol, the ratio of herbals to ethanol was 1:10. Healthy 25 white albino mice (male weighing between 17-30 gram) used in this study. They were kept in large airy cages in groups of 5 animals per cage with free access to food and water. Five doses (8-20 g/kg) were then chosen for the determination of intraperitoneal LD50 in mice and given to five groups of albino mice. The animals were observed for first 2 hours and then at 6th and 24th hour for any toxicsymptoms. After 24 hours, the number of deceased mice was counted in each group. The percentage of animals that died at each dose level was transformed and then LD50 determined by the methods of Karber and Pershin.G.N.The LD50 of Tetima herbal compound in mice was determined to be 14.3 g/kg after intraperitonealinjection. There was no difference occurred between Karber and Pershin methods to evaluate acute toxicity. In the animals receiving intraperitoneal injection, the abdominal muscle contractions and ataxia was observed, which persisted for few hours. At the 6th hour they were drowsy and less responsive. The severity of these effects was related to the level of dose. However, at 24th hour most of the survivors had recovered from these symptoms.Tetima herbal compound extract is a relatively safe, particularly when given intraperitoneal inject toexperimental animals.

BACKGROUND. The Mongolian traditional medicine Anar-5 is excellent for weak digestion and helps with stomach irritation, loss of appetite, and resulting body weakness. Anar-5 blends punicagranatum, cinnamomum cassia presl, piper longum, cardamom and alpiniaofficinarum. We are establish an experimental animal of chronic gastritis to investigate the effect of traditional medicine Anar-5 on rats gastric mucosa. Methods: In this study, the protective effect preparation in sixty five healthy, male wistar rats were treated with intragastric administration of ammonia water 0.1%. To rats in three experiments for 2 week, 4 week, and 6wk, gastric tissues were examined histopathologically for atrophic changes and blood’s gastrin produced by preparation treatment. Results: After the treatment of animals blood’s gastrin was significantly different from that in control group (p<0.05), and the gastric mucosal inflammation was infiltration of inflammatory cells, decreased thickness of lamina propria. Conclusion: Treatment with preparation from Anar-5 protectived by the chronic gastritis and gastric atrophy.

Introduction: Globally, 10.5-25.9 million cases of pyelonephritis have been reported, and the nature of the disease is changing over time. In Mongolia, as of 2022 diseases of the genitourinary system has increased from the average of the last 10 years, and account for 9% of all diseases. The incidence rate by age group increased in all age groups in 2022 compared to 2013, with the largest increase in the age group over 65 with 2,104 cases. The basis of this study is to determine the use of PIM drugs based on the Beers criteria for the treatment of patients diagnosed with pyelonephritis in our country. To study the use of drugs by inpatients diagnosed with pyelonephritis (N10), (N11) in referral hospitals and the use of PIM drugs used in the treatment of elderly people. Methods: A retrospective descriptive study was conducted on the medical history of a total of 150 patients diagnosed with pyelonephritis (year 2023) at The State Secondary Central Hospital, The State Third Central Hospital, and Hovd Regional Medical Centers. Among the 150 inpatients who participated in our study, 14.3% (n=18) of 126 types of drugs were used for the treatment of pyelonephritis, and 85.7% (n=108) for the treatment of multimorbidity and supportive treatment. Inpatients used 11 types of PIM drugs according to Beers criteria. Nitrofurantoin 39% was used the most and amitriptyline 9.8% were the most used drugs affecting the central nervous system. Conclusion 11 types of drugs included in the inappropriate category for use in the elderly are risky and should not be selected. Among them, nitrofurantoin 39%, from NSAIDs ketoprofen 19.5%, ibuprofen 7.3% were most used. PIM drugs used for treatment in 2014 are still used in 2024, indicating the need for improved drug monitoring in the elderly